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Gene Review

CCKBR  -  cholecystokinin B receptor

Bos taurus

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High impact information on CCKBR

  • The neurogenic vasodilatation induced by CCK-4 was blocked by the CCK2R antagonist, L-365,260, and antagonized by neuronal NO synthase (nNOS) inhibitors, but was independent of the endothelium [1].
  • The authors report that cholecystokinin (CCK), via its subtype 2 receptor (CCK2R) located presynaptically on cerebral arteries, mediates the release of nitric oxide (NO), which induces vasodilatation [1].
  • Pharmacological analysis using selective agonists and antagonists indicated the expression of the CCK-A receptor at birth, whereas the CCK-B receptor predominated at postnatal stages [2].
  • The effect of luminal gastrin on the secretion of pancreatic juice was studied in seven conscious preruminant calves employing luminal infusions of gastrin and cholecystokinin (CCK)-9 and pharmacological CCK1 and CCK2 receptor blocks with antagonists [3].
  • The effect of caerulein was antagonized by devazepide, a selective CCKA-receptor antagonist, but not by L-365.260, a selective CCKB-receptor antagonist [4].


  1. Cholecystokinin induces cerebral vasodilatation via presynaptic CCK2 receptors: new implications for the pathophysiology of panic. Sánchez-Fernández, C., González, C., Mercer, L.D., Beart, P.M., Ruiz-Gayo, M., Fernández-Alfonso, M.S. J. Cereb. Blood Flow Metab. (2003) [Pubmed]
  2. Differential expression of A- and B-subtypes of cholecystokinin/gastrin receptors in the developing calf pancreas. Le Meuth, V., Philouze-Rome, V., Le Huerou-Luron, I., Formal, M., Vaysse, N., Gespach, C., Guilloteau, P., Fourmy, D. Endocrinology (1993) [Pubmed]
  3. The role of luminal gastrin in the regulation of pancreatic juice secretion in preruminant calves. Zabielski, R., Normand, V., Romé, V., Woliński, J., Chayvialle, J.A., Guilloteau, P. Regul. Pept. (2004) [Pubmed]
  4. Evidence for cholecystokininA receptors in bovine adrenal chromaffin cells. Aarnisalo, A.M., Vainio, P.J., Männistö, P.T., Vasar, E., Tuominen, R.K. Neuroreport (1996) [Pubmed]
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