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Gene Review

Cckbr  -  cholecystokinin B receptor

Mus musculus

Synonyms: CCK-B receptor, CCK-B/gastrin receptor, CCK-BR, CCK2-R, CCK2/gastrin, ...
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Disease relevance of Cckbr


Psychiatry related information on Cckbr

  • Moreover, the locomotor activity of heterozygous (+/-) and homozygous (-/-) CCK2R receptor-deficient mice was somewhat reduced [6].
  • These results indicate that blocking of CCKB receptors could result in an increase of extracellular dopamine contents in some brain areas involved in depression and suggest a potential use of CCKB receptor antagonists, alone or combined with antidepressants, in the treatment of depressive syndromes [7].
  • We investigated the role of the CCK2 receptor in anxiety by evaluating the behavior of mice lacking the gene for this receptor in these standard anxiety models (i.e., exploratory behavior in a black and white test box and exploratory behavior in an elevated plus-maze) [8].

High impact information on Cckbr

  • Peptides encoded by the gastrin gene are an important part of this system because targeted deletion of the gene, or of the gastrin-CCKB receptor gene, leads to decreased numbers of parietal cells and decreased gastric acid secretion [9].
  • Addition of the CCK-2R inhibitor significantly decreased gene and shedding up-regulation [10].
  • In a pancreatic tumor cell line expressing the endogenous CCK2R, we demonstrated the activation of the JAK2/STAT3 pathway by this receptor and the involvement of this signaling pathway in the proliferative effects of the CCK2R [11].
  • Cholecystokinin-2 receptor modulates cell adhesion through beta1-integrin in human pancreatic cancer cells [12].
  • Several lines of evidence suggest that gastrin and the CCK-2 receptor (CCK2R) could contribute to pancreatic carcinogenesis by modulating processes such as proliferation, cell adhesion or migration [12].

Biological context of Cckbr


Anatomical context of Cckbr


Associations of Cckbr with chemical compounds


Physical interactions of Cckbr

  • The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1 [19].
  • Collectively, these data suggest that CCK interacts at the CCKB receptor to inhibit tonically the release and/or availability of an endogenous substance acting at opioid delta receptors [22].

Regulatory relationships of Cckbr


Other interactions of Cckbr


Analytical, diagnostic and therapeutic context of Cckbr


  1. Localization of the murine cholecystokinin A and B receptor genes. Samuelson, L.C., Isakoff, M.S., Lacourse, K.A. Mamm. Genome (1995) [Pubmed]
  2. Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice. Kurrikoff, K., Kõks, S., Matsui, T., Bourin, M., Arend, A., Aunapuu, M., Vasar, E. Eur. J. Neurosci. (2004) [Pubmed]
  3. Is the CCK2 receptor essential for normal regulation of body weight and adiposity? Chen, H., Kent, S., Morris, M.J. Eur. J. Neurosci. (2006) [Pubmed]
  4. Transgenic mice expressing cholecystokinin 2 receptors in the pancreas. Clerc, P., Saillan-Barreau, C., Desbois, C., Pradayrol, L., Fourmy, D., Dufresne, M. Pharmacol. Toxicol. (2002) [Pubmed]
  5. Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice. Clerc, P., Coll Constans, M.G., Lulka, H., Broussaud, S., Guigné, C., Leung-Theung-Long, S., Perrin, C., Knauf, C., Carpéné, C., Pénicaud, L., Seva, C., Burcelin, R., Valet, P., Fourmy, D., Dufresne, M. Endocrinology (2007) [Pubmed]
  6. Cholecystokinin2 receptor-deficient mice display altered function of brain dopaminergic system. Kõks, S., Volke, V., Veraksits, A., Rünkorg, K., Sillat, T., Abramov, U., Bourin, M., Huotari, M., Männistö, P.T., Matsui, T., Vasar, E. Psychopharmacology (Berl.) (2001) [Pubmed]
  7. The CCKB receptor antagonist, L-365,260, elicits antidepressant-type effects in the forced-swim test in mice. Hernando, F., Fuentes, J.A., Roques, B.P., Ruiz-Gayo, M. Eur. J. Pharmacol. (1994) [Pubmed]
  8. Reduced anxious behavior in mice lacking the CCK2 receptor gene. Horinouchi, Y., Akiyoshi, J., Nagata, A., Matsushita, H., Tsutsumi, T., Isogawa, K., Noda, T., Nagayama, H. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2004) [Pubmed]
  9. The gastrins: their production and biological activities. Dockray, G.J., Varro, A., Dimaline, R., Wang, T. Annu. Rev. Physiol. (2001) [Pubmed]
  10. Helicobacter pylori can induce heparin-binding epidermal growth factor expression via gastrin and its receptor. Dickson, J.H., Grabowska, A., El-Zaatari, M., Atherton, J., Watson, S.A. Cancer Res. (2006) [Pubmed]
  11. A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models. Ferrand, A., Kowalski-Chauvel, A., Bertrand, C., Escrieut, C., Mathieu, A., Portolan, G., Pradayrol, L., Fourmy, D., Dufresne, M., Seva, C. J. Biol. Chem. (2005) [Pubmed]
  12. Cholecystokinin-2 receptor modulates cell adhesion through beta1-integrin in human pancreatic cancer cells. Cayrol, C., Clerc, P., Bertrand, C., Gigoux, V., Portolan, G., Fourmy, D., Dufresne, M., Seva, C. Oncogene (2006) [Pubmed]
  13. Structure and developmental expression of the mouse CCK-B receptor gene. Lay, J.M., Jenkins, C., Friis-Hansen, L., Samuelson, L.C. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  14. Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor. Miyasaka, K., Ichikawa, M., Ohta, M., Kanai, S., Yoshida, Y., Masuda, M., Nagata, A., Matsui, T., Noda, T., Takiguchi, S., Takata, Y., Kawanami, T., Funakoshi, A. J. Nutr. (2002) [Pubmed]
  15. Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor: a study of CCK-A,B, and AB receptor gene knockout mice. Miyasaka, K., Ohta, M., Kanai, S., Yoshida, Y., Sato, N., Nagata, A., Matsui, T., Noda, T., Jimi, A., Takiguchi, S., Takata, Y., Kawanami, T., Funakoshi, A. J. Gastroenterol. (2004) [Pubmed]
  16. Differences in ethanol ingestion between cholecystokinin-A receptor deficient and -B receptor deficient mice. Miyasaka, K., Hosoya, H., Takano, S., Ohta, M., Sekime, A., Kanai, S., Matsui, T., Funakoshi, A. Alcohol Alcohol. (2005) [Pubmed]
  17. Gastric phenotypic abnormality in cholecystokinin 2 receptor null mice. Chen, D., Zhao, C.M., Håkanson, R., Rehfeld, J.F. Pharmacol. Toxicol. (2002) [Pubmed]
  18. Synthesis and X-ray crystallographic analysis of quinazolinone cholecystokinin/gastrin receptor ligands. Yu, M.J., McCowan, J.R., Mason, N.R., Deeter, J.B., Mendelsohn, L.G. J. Med. Chem. (1992) [Pubmed]
  19. The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1. Arnould, M., Tassa, A., Ferrand, A., Archer, E., Estève, J.P., Pénalba, V., Portolan, G., Escherich, A., Moroder, L., Fourmy, D., Seva, C., Dufresne, M. FEBS Lett. (2004) [Pubmed]
  20. Effects of cholecystokinin-B receptor antagonist on dopamine system in tenascin mutant mice. Fukamauchi, F., Wang, Y.J., Mataga, N., Kusakabe, M. Neuroreport (1997) [Pubmed]
  21. Effects of CCK antagonists on CCK-induced suppression of locomotor activity in mice. Hirosue, Y., Inui, A., Miura, M., Nakajima, M., Okita, M., Himori, N., Baba, S., Kasuga, M. Peptides (1992) [Pubmed]
  22. Enhancement of morphine antinociception by a CCKB antagonist in mice is mediated via opioid delta receptors. Vanderah, T.W., Bernstein, R.N., Yamamura, H.I., Hruby, V.J., Porreca, F. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  23. Cholecystokinin-induced antinociception is not blocked by CCK-A or CCK-B receptor antagonists. Williams, C.L., Rosenfeld, G.C., Burks, T.F. Peptides (1997) [Pubmed]
  24. Gastrin stimulates the growth of gastric pit cell precursors by inducing its own receptors. Nakajima, T., Konda, Y., Izumi, Y., Kanai, M., Hayashi, N., Chiba, T., Takeuchi, T. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  25. Genetic dissection of the signaling pathways that control gastric acid secretion. Chen, D., Friis-Hansen, L., Håkanson, R., Zhao, C.M. Inflammopharmacology. (2005) [Pubmed]
  26. Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception. Vanderah, T.W., Lai, J., Yamamura, H.I., Porreca, F. Neuroreport (1994) [Pubmed]
  27. A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test. Noble, F., Blommaert, A., Fournié-Zaluski, M.C., Roques, B.P. Eur. J. Pharmacol. (1995) [Pubmed]
  28. Synthesis and evaluation of 11C-labeled nonpeptide antagonists for cholecystokinin receptors: [11C]L-365,260 and [11C]L-365,346. Haradahira, T., Inoue, O., Kobayashi, K., Suzuki, K. Nucl. Med. Biol. (1998) [Pubmed]
  29. Secretory organelles in ECL cells: effects of pharmacological blockade of the gastrin/CCK2 receptor versus its elimination by gene targeting. Zhao, C.M., Håkanson, R., Chen, D. Inflammopharmacology. (2005) [Pubmed]
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