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Gene Review

CEACAM5  -  carcinoembryonic antigen

Bos taurus

Synonyms: CEA, CEACAM
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Disease relevance of CEACAM5

  • CEA is a low-risk procedure for significant carotid stenosis; however, females are more likely to develop restenosis after carotid surgery, especially with Dacron patches [1].
  • Adenovirus vectors encoding carcinoembryonic antigen (Ad-CEA) or costimulatory molecules CD80, intercellular adhesion molecule-1 (ICAM-1) and leucocyte function-associated antigen-3 (LFA-3) (Ad-STIM) were used to transduce murine bone marrow-derived dendritic cells (BMDC) [2].

High impact information on CEACAM5

  • Analysis of the kinetics of CEA binding to rabbit anti-CEA antibody insolubilized on filter paper discs provided six lines of evidence indicating diffusion control of this reaction: 1) The observed forward rate constant, k1obs, decreased when solvent viscosity was increased with sucrose or Ficoll [3].
  • METHODS: Biotinylated antibodies against alpha-fetoprotein (AFP), interleukin-6 (IL-6), and carcinoembryonic antigen [(CEA); 0.1 g/L each in 15 mmol/L phosphate-buffered saline (PBS) containing 0.1 mL/L Tween 20] were attached to a microcolumn packed with streptavidin-coated particles [4].
  • An attempt has been made to determine relative potencies of four Carcinoembryonic Antigen (CEA) reference preparations, including the World Health Organization CEA standard, assayed by three kits (Abbott, Cis, Roche) [5].
  • Nonetheless, CEA-specific CD8+ T-cell response was enhanced upon coinfection of Ad-STIM and Ad-CEA in both mouse strains, although this immune response was not sufficient to protect CEA-tg mice from tumour challenge [2].
  • Production of hybrids secreting bispecific antibodies recognising CEA and doxorubicin [6].

Associations of CEACAM5 with chemical compounds

  • A group of 10 experimental calves that lived for 61-147 days with a TAH was used to study serum aldosterone levels by RIA with ALDOCTK-125 CEA Kit (Sorin Biomedica, Italy) [7].

Other interactions of CEACAM5

  • Immunohistochemically, all bovine myocardial tumors stained positively for cytokeratin (8/8), and occasional masses stained positively for vimentin (3/8) or carcinoembryonic antigen (3/8) [8].

Analytical, diagnostic and therapeutic context of CEACAM5

  • Relative potencies of four CEA preparations assayed by three commercial radioimmunoassay kits [5].


  1. Effect of age and gender on restenosis after carotid endarterectomy. Hugl, B., Oldenburg, W.A., Neuhauser, B., Hakaim, A.G. Annals of vascular surgery (2006) [Pubmed]
  2. Adenovirus transduction and culture conditions affect the immunogenicity of murine dendritic cells. Salucci, V., Lena, A.M., Ciliberto, G., Scarselli, E., La Monica, N. Scand. J. Immunol. (2005) [Pubmed]
  3. Diffusion control of the binding of carcinoembryonic antigen (CEA) with insoluble anti-CEA antibody. Frackelton, A.R., Weltman, J.K. J. Immunol. (1980) [Pubmed]
  4. Simultaneous multiple immunoassays in a compact disc-shaped microfluidic device based on centrifugal force. Honda, N., Lindberg, U., Andersson, P., Hoffmann, S., Takei, H. Clin. Chem. (2005) [Pubmed]
  5. Relative potencies of four CEA preparations assayed by three commercial radioimmunoassay kits. Sizaret, P., Estève, J. J. Immunol. Methods (1980) [Pubmed]
  6. Production of hybrids secreting bispecific antibodies recognising CEA and doxorubicin. Reddy, V.S., Ford, C.H. Anticancer Res. (1993) [Pubmed]
  7. Serum aldosterone studies in 10 calves living for 2-5 months with a total artificial heart (TAH). Dostál, M., Vasků, J., Bílková, B., Cerný, J., Vasků, J., Sotolová, O., Vasků, A., Urbánek, P., Gregor, Z., Guba, P. The International journal of artificial organs. (1988) [Pubmed]
  8. Bovine myocardial epithelial inclusions. Baker, D.C., Schmidt, S.P., Langheinrich, K.A., Cannon, L., Smart, R.A. Vet. Pathol. (1993) [Pubmed]
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