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Gene Review

PTRF  -  polymerase I and transcript release factor

Homo sapiens

Synonyms: CAVIN, CAVIN1, CGL4, Cavin-1, FKSG13, ...
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High impact information on PTRF

  • Substitution of 3'-terminal uridylates by guanine residues abolishes PTRF binding and impairs release activity [1].
  • PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters [2].
  • One cDNA contained a potential open reading frame for a polypeptide of 392 amino acids and was identical to PTRF (polymerase I and transcript-release factor), which is involved in transcription termination of the RNA polymerase I reaction [2].
  • Polymerase I and transcript release factor (PTRF) is in human adipocytes mainly localized at the plasma membrane [3].
  • In the plasma membrane PTRF was specifically bound to a triacylglycerol-metabolizing subclass of caveolae containing hormone-sensitive lipase (HSL) [3].

Biological context of PTRF


Anatomical context of PTRF

  • PTRF was present at the surface of caveolae in the intact form and in five different truncated forms [4].
  • Caveolae of human adipocytes are proposed to function in targeting, relocation and proteolytic control of PTRF and other PEST-domain-containing signalling proteins [4].
  • In response to insulin PTRF was translocated to the cytosol in parallel with HSL [3].

Other interactions of PTRF


Analytical, diagnostic and therapeutic context of PTRF


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