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Gene Review

LIPE  -  lipase, hormone-sensitive

Homo sapiens

Synonyms: AOMS4, HSL, Hormone-sensitive lipase, LHS
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Disease relevance of LIPE


Psychiatry related information on LIPE

  • This study retrospectively investigated the effect of left (LHS) versus right (RHS) hippocampal sclerosis on verbal memory, measured by means of the Paired Associate Learning and Logical Memory subtests of the Wechsler Memory Scale (WMS) administered as part of a routine preoperative assessment [6].

High impact information on LIPE

  • A flurry of research over the past decade has led to significant understanding of many aspects of quorum sensing including the synthesis of acyl-HSLs, the receptors that recognize the acyl-HSL signal and transduce this information to the level of gene expression, and the interaction of these receptors with the transcriptional machinery [7].
  • Variations in the maximum lipolysis rate correlated significantly with the variations in hormone-sensitive lipase activity in the whole material, and with the serum values for triglycerides, HDL cholesterol and apoB lipoprotein within the control group, but the serum triglyceride values in FCHL were higher than this correlation predicted [8].
  • In conclusion, a decreased activation of the hormone-sensitive lipase complex appears to be the mechanism underlying a blunted lipolytic response of fat cells to catecholamine stimulation in elderly subjects [9].
  • (2003) provide convincing support to the notion that the subcellular compartmentalization of lipase also regulates lipolysis, and, more importantly, that proteins other than HSL are localized to the lipid droplet and are indispensable for its optimal hydrolysis [10].
  • Hormone-sensitive lipase (HSL) is a cytosolic neutral lipase that functions as the rate-limiting enzyme for the mobilization of free fatty acids in adipose tissue [11].

Chemical compound and disease context of LIPE


Biological context of LIPE


Anatomical context of LIPE


Associations of LIPE with chemical compounds


Physical interactions of LIPE


Enzymatic interactions of LIPE

  • In conclusion, the present study suggests that AMPK phosphorylates HSL on Ser565 in human skeletal muscle during exercise with reduced muscle glycogen [21].

Regulatory relationships of LIPE


Other interactions of LIPE


Analytical, diagnostic and therapeutic context of LIPE


  1. A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: indication for linkage with islet 1 locus on chromosome 5q. Clément, K., Dina, C., Basdevant, A., Chastang, N., Pelloux, V., Lahlou, N., Berlan, M., Langin, D., Guy-Grand, B., Froguel, P. Diabetes (1999) [Pubmed]
  2. Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity. Mairal, A., Langin, D., Arner, P., Hoffstedt, J. Diabetologia (2006) [Pubmed]
  3. C3, hormone-sensitive lipase, and peroxisome proliferator-activated receptor gamma expression in adipose tissue of familial combined hyperlipidemia patients. Ylitalo, K., Nuotio, I., Viikari, J., Auwerx, J., Vidal, H., Taskinen, M.R. Metab. Clin. Exp. (2002) [Pubmed]
  4. Adipose tissue lipoprotein lipase and hormone-sensitive lipase. Contrasting findings in familial combined hyperlipidemia and insulin resistance syndrome. Reynisdottir, S., Angelin, B., Langin, D., Lithell, H., Eriksson, M., Holm, C., Arner, P. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  5. Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Coppack, S.W., Evans, R.D., Fisher, R.M., Frayn, K.N., Gibbons, G.F., Humphreys, S.M., Kirk, M.L., Potts, J.L., Hockaday, T.D. Metab. Clin. Exp. (1992) [Pubmed]
  6. Lateralization of verbal memory and unilateral hippocampal sclerosis: evidence of task-specific effects. Saling, M.M., Berkovic, S.F., O'Shea, M.F., Kalnins, R.M., Darby, D.G., Bladin, P.F. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (1993) [Pubmed]
  7. Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing. Fuqua, C., Parsek, M.R., Greenberg, E.P. Annu. Rev. Genet. (2001) [Pubmed]
  8. Impaired activation of adipocyte lipolysis in familial combined hyperlipidemia. Reynisdottir, S., Eriksson, M., Angelin, B., Arner, P. J. Clin. Invest. (1995) [Pubmed]
  9. Catecholamine-induced lipolysis in adipose tissue of the elderly. Lönnqvist, F., Nyberg, B., Wahrenberg, H., Arner, P. J. Clin. Invest. (1990) [Pubmed]
  10. Lipolysis: more than just a lipase. Birnbaum, M.J. J. Cell Biol. (2003) [Pubmed]
  11. Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein. Shen, W.J., Sridhar, K., Bernlohr, D.A., Kraemer, F.B. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  12. Lipoprotein lipase and hormone-sensitive lipase activities in human subcutaneous lipomas: comparison with normal subcutaneous adipose tissue. Giudicelli, Y., Pecquery, R., Agli, B., Jamin, C., Quevauvilliers, J. Clinical science and molecular medicine. (1976) [Pubmed]
  13. A low-iron-available, polyphenol-enriched, carbohydrate-restricted diet to slow progression of diabetic nephropathy. Facchini, F.S., Saylor, K.L. Diabetes (2003) [Pubmed]
  14. Genetic variation at the hormone sensitive lipase: gender-specific association with plasma lipid and glucose concentrations. Qi, L., Shen, H., Larson, I., Barnard, J.R., Schaefer, E.J., Ordovas, J.M. Clin. Genet. (2004) [Pubmed]
  15. Effects of Aralia mandshurica and Engelhardtia chrysolepis extracts on some parameters of lipid metabolism in women with nondiabetic obesity. Abidov, M.T., del Rio, M.J., Ramazanov, T.Z., Klimenov, A.L., Dzhamirze, S.h., Kalyuzhin, O.V. Bull. Exp. Biol. Med. (2006) [Pubmed]
  16. Pharmacology, molecular identification and functional characteristics of vasoactive intestinal peptide receptors in human breast cancer cells. Gespach, C., Bawab, W., de Cremoux, P., Calvo, F. Cancer Res. (1988) [Pubmed]
  17. The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study. Garenc, C., Pérusse, L., Chagnon, Y.C., Rankinen, T., Gagnon, J., Borecki, I.B., Leon, A.S., Skinner, J.S., Wilmore, J.H., Rao, D.C., Bouchard, C. Int. J. Obes. Relat. Metab. Disord. (2002) [Pubmed]
  18. Mapping of the gene for hormone sensitive lipase (LIPE) to chromosome 19q13.1-->q13.2. Levitt, R.C., Liu, Z., Nouri, N., Meyers, D.A., Brandriff, B., Mohrenweiser, H.M. Cytogenet. Cell Genet. (1995) [Pubmed]
  19. Physical association between the adipocyte fatty acid-binding protein and hormone-sensitive lipase: a fluorescence resonance energy transfer analysis. Smith, A.J., Sanders, M.A., Thompson, B.R., Londos, C., Kraemer, F.B., Bernlohr, D.A. J. Biol. Chem. (2004) [Pubmed]
  20. Age-related differences in messenger ribonucleic acid expression of key proteins involved in adipose cell differentiation and metabolism. Imbeault, P., Vidal, H., Tremblay, A., Vega, N., Nadeau, A., Després, J.P., Mauriège, P. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  21. Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise. Roepstorff, C., Vistisen, B., Donsmark, M., Nielsen, J.N., Galbo, H., Green, K.A., Hardie, D.G., Wojtaszewski, J.F., Richter, E.A., Kiens, B. J. Physiol. (Lond.) (2004) [Pubmed]
  22. 17Beta-estradiol and anti-estrogen ICI:compound 182,780 regulate expression of lipoprotein lipase and hormone-sensitive lipase in isolated subcutaneous abdominal adipocytes. Palin, S.L., McTernan, P.G., Anderson, L.A., Sturdee, D.W., Barnett, A.H., Kumar, S. Metab. Clin. Exp. (2003) [Pubmed]
  23. The effects of tolbutamide on lipoproteins, lipoprotein lipase and hormone-sensitive lipase. Agardh, C.D., Björgell, P., Nilsson-Ehle, P. Diabetes Res. Clin. Pract. (1999) [Pubmed]
  24. Characterization of the functional interaction of adipocyte lipid-binding protein with hormone-sensitive lipase. Shen, W.J., Liang, Y., Hong, R., Patel, S., Natu, V., Sridhar, K., Jenkins, A., Bernlohr, D.A., Kraemer, F.B. J. Biol. Chem. (2001) [Pubmed]
  25. Association and insulin regulated translocation of hormone-sensitive lipase with PTRF. Aboulaich, N., Ortegren, U., Vener, A.V., Str??lfors, P. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  26. Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling. Watt, M.J., Steinberg, G.R., Chan, S., Garnham, A., Kemp, B.E., Febbraio, M.A. FASEB J. (2004) [Pubmed]
  27. Peroxisome proliferator-activated receptor-gamma transcriptionally up-regulates hormone-sensitive lipase via the involvement of specificity protein-1. Deng, T., Shan, S., Li, P.P., Shen, Z.F., Lu, X.P., Cheng, J., Ning, Z.Q. Endocrinology (2006) [Pubmed]
  28. Expression of human hormone-sensitive lipase in white adipose tissue of transgenic mice increases lipase activity but does not enhance in vitro lipolysis. Lucas, S., Tavernier, G., Tiraby, C., Mairal, A., Langin, D. J. Lipid Res. (2003) [Pubmed]
  29. The effect of interleukin-1 and interleukin-2 on the adrenergic control of hormone-sensitive lipase in the human adipocyte. Gagner, M., Shizgal, H.M., Forse, R.A. Surgery (1986) [Pubmed]
  30. Hormone sensitive lipase expression and adipose tissue metabolism show gender difference in obese subjects after weight loss. Kolehmainen, M., Vidal, H., Ohisalo, J.J., Pirinen, E., Alhava, E., Uusitupa, M.I. Int. J. Obes. Relat. Metab. Disord. (2002) [Pubmed]
  31. Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose. Smih, F., Rouet, P., Lucas, S., Mairal, A., Sengenes, C., Lafontan, M., Vaulont, S., Casado, M., Langin, D. Diabetes (2002) [Pubmed]
  32. Human immortalized brown adipocytes express functional beta3-adrenoceptor coupled to lipolysis. Zilberfarb, V., Piétri-Rouxel, F., Jockers, R., Krief, S., Delouis, C., Issad, T., Strosberg, A.D. J. Cell. Sci. (1997) [Pubmed]
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