The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

ZNF148  -  zinc finger protein 148

Homo sapiens

Synonyms: BERF-1, BFCOL1, HT-BETA, Transcription factor ZBP-89, ZBP-89, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of ZNF148

 

High impact information on ZNF148

 

Biological context of ZNF148

 

Anatomical context of ZNF148

 

Associations of ZNF148 with chemical compounds

 

Physical interactions of ZNF148

  • Although ZBP-89 binds mutant and wild-type p53, only wild-type p53 is stabilized [14].
  • Collectively, the data suggest that ZBP-99 binds GC-rich promoters and may complement the activities mediated by ZBP-89 [15].
 

Regulatory relationships of ZNF148

 

Other interactions of ZNF148

  • Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells [8].
  • Taken together, ZBP-89-mediated apoptosis occurs via a p53-independent mechanism that requires JNK activation [9].
  • Moreover, activated Stat3 can overcome ZBP-89 repression [17].
  • PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters [18].
  • Taken together, we conclude that ZBP-89 is required for constitutive STAT1 expression and in this way contributes to the ability of cells to be activated by IFNgamma [19].
 

Analytical, diagnostic and therapeutic context of ZNF148

References

  1. Intestinal overexpression of ZNF148 suppresses Apc(Min)/+ neoplasia. Law, D.J., Labut, E.M., Merchant, J.L. Mamm. Genome (2006) [Pubmed]
  2. A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomas. De Bustos, C., Smits, A., Strömberg, B., Collins, V.P., Nistér, M., Afink, G. J. Med. Genet. (2005) [Pubmed]
  3. Recruitment of Ataxia-Telangiectasia Mutated to the p21(waf1) Promoter by ZBP-89 Plays a Role in Mucosal Protection. Bai, L., Kao, J.Y., Law, D.J., Merchant, J.L. Gastroenterology (2006) [Pubmed]
  4. Definitive identification of a member of the Epstein-Barr virus nuclear protein 3 family. Hennessy, K., Wang, F., Bushman, E.W., Kieff, E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  5. The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene. Park, H., Shelley, C.S., Arnaout, M.A. Blood (2003) [Pubmed]
  6. ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter. Merchant, J.L., Iyer, G.R., Taylor, B.R., Kitchen, J.R., Mortensen, E.R., Wang, Z., Flintoft, R.J., Michel, J.B., Bassel-Duby, R. Mol. Cell. Biol. (1996) [Pubmed]
  7. Regulation of epithelial cell growth by ZBP-89: potential relevance in pancreatic cancer. Bai, L., Logsdon, C., Merchant, J.L. International journal of gastrointestinal cancer. (2002) [Pubmed]
  8. Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells. Bai, L., Merchant, J.L. J. Biol. Chem. (2000) [Pubmed]
  9. ZBP-89-induced apoptosis is p53-independent and requires JNK. Bai, L., Yoon, S.O., King, P.D., Merchant, J.L. Cell Death Differ. (2004) [Pubmed]
  10. Intestinal alkaline phosphatase gene expression is activated by ZBP-89. Malo, M.S., Mozumder, M., Zhang, X.B., Biswas, S., Chen, A., Bai, L.C., Merchant, J.L., Hodin, R.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  11. Inhibition of Growth Hormone Receptor Gene Expression by Saturated Fatty Acids: Role of Kruppel-Like Zinc Finger Factor, ZBP-89. Thimmarayappa, J., Sun, J., Schultz, L.E., Dejkhamron, P., Lu, C., Giallongo, A., Merchant, J.L., Menon, R.K. Mol. Endocrinol. (2006) [Pubmed]
  12. ZBP-89, a Krüppel-type zinc finger protein, inhibits cell proliferation. Remington, M.C., Tarlé, S.A., Simon, B., Merchant, J.L. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  13. ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1. Zhang, X., Diab, I.H., Zehner, Z.E. Nucleic Acids Res. (2003) [Pubmed]
  14. ZBP-89 mediates butyrate regulation of gene expression. Merchant, J.L., Bai, L., Okada, M. J. Nutr. (2003) [Pubmed]
  15. ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression. Law, D.J., Du, M., Law, G.L., Merchant, J.L. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  16. The Epstein-Barr virus protein BMRF1 activates gastrin transcription. Holley-Guthrie, E.A., Seaman, W.T., Bhende, P., Merchant, J.L., Kenney, S.C. J. Virol. (2005) [Pubmed]
  17. Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89. Wu, Y., Diab, I., Zhang, X., Izmailova, E.S., Zehner, Z.E. Oncogene (2004) [Pubmed]
  18. PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters. Hasegawa, T., Takeuchi, A., Miyaishi, O., Xiao, H., Mao, J., Isobe, K. Biochem. J. (2000) [Pubmed]
  19. Transcription factor ZBP-89 is required for STAT1 constitutive expression. Bai, L., Merchant, J.L. Nucleic Acids Res. (2003) [Pubmed]
  20. P53 mutants suppress ZBP-89 function. Okada, M., Tessier, A., Bai, L., Merchant, J.L. Anticancer Res. (2006) [Pubmed]
 
WikiGenes - Universities