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Gene Review

iap  -  iap

Neodiprion sertifer nucleopolyhedrovirus

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Disease relevance of iap


High impact information on iap

  • The iap genes encode a C3HC4 (or RING) finger motif found in a number of transcriptional regulatory proteins, as well as two additional Cys/His motifs (baculovirus iap repeats) [1].
  • P35 is a 35-kDa protein that can suppress apoptosis induced by virus infection or by diverse stimuli in vertebrates or invertebrates. iap homologues were identified in insects and mammals [4].
  • The only repeated ORFs are the four iap genes [5].
  • The activity of the iap genes was tested by transient expression in Spodoptera frugiperda (Sf-21) cells treated with the apoptosis-inducing agents actinomycin D, cycloheximide, anisomycin, tumour necrosis factor-alpha and UV light [6].
  • Using an antisense Tn-iap probe, two major transcripts of approximately 800 nt and 1600 nt were detected by Northern blot analysis of RNA extracted from the fat body of T. ni larvae infected with the TnGV [3].


  1. Control of programmed cell death by the baculovirus genes p35 and iap. Clem, R.J., Miller, L.K. Mol. Cell. Biol. (1994) [Pubmed]
  2. Functional analysis of the inhibitor of apoptosis (iap) gene carried by the entomopoxvirus of Amsacta moorei. Li, Q., Liston, P., Moyer, R.W. J. Virol. (2005) [Pubmed]
  3. A baculovirus anti-apoptosis gene homolog of the Trichoplusia ni granulovirus. Bideshi, D.K., Anwar, A.T., Federici, B.A. Virus Genes (1999) [Pubmed]
  4. Characterization of the apoptosis suppressor protein P49 from the Spodoptera littoralis nucleopolyhedrovirus. Pei, Z., Reske, G., Huang, Q., Hammock, B.D., Qi, Y., Chejanovsky, N. J. Biol. Chem. (2002) [Pubmed]
  5. Whole genome analysis of the Epiphyas postvittana nucleopolyhedrovirus. Hyink, O., Dellow, R.A., Olsen, M.J., Caradoc-Davies, K.M., Drake, K., Herniou, E.A., Cory, J.S., O'Reilly, D.R., Ward, V.K. J. Gen. Virol. (2002) [Pubmed]
  6. The inhibitors of apoptosis of Epiphyas postvittana nucleopolyhedrovirus. Maguire, T., Harrison, P., Hyink, O., Kalmakoff, J., Ward, V.K. J. Gen. Virol. (2000) [Pubmed]
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