The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

LGALS13  -  lectin, galactoside-binding, soluble, 13

Homo sapiens

Synonyms: GAL13, Gal-13, Galactoside-binding soluble lectin 13, Galectin-13, PLAC8, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LGALS13

  • Median PP-13 levels for controls, all cases and early pre-eclampsia cases were 176.9, 121.9 and 111.7 pg/mL, with multiples of the median (MoMs) of 1.00, 0.69 and 0.63, respectively (P < 0.001) [1].

High impact information on LGALS13


Biological context of LGALS13


Anatomical context of LGALS13


Physical interactions of LGALS13

  • The primary structure of the newly sequence analysed placental tissue protein 13 (PP13) was highly homologous to several members of the beta-galactoside-binding S-type lectin (galectin) family [7].

Other interactions of LGALS13

  • From one human term placenta an average of 3.7 mg PP13 and 2.5 mg PP17 could be extracted [8].
  • First-trimester PAPP-A provides some prediction for pre-eclamspia when combined with PI but does not add to the prediction of early pre-eclampsia when PP-13 and PI are used together [1].

Analytical, diagnostic and therapeutic context of LGALS13


  1. First-trimester maternal serum PP-13, PAPP-A and second-trimester uterine artery Doppler pulsatility index as markers of pre-eclampsia. Spencer, K., Cowans, N.J., Chefetz, I., Tal, J., Meiri, H. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2007) [Pubmed]
  2. Emergence and spread of community-associated methicillin-resistant Staphylococcus aureus in rural Wisconsin, 1989 to 1999. Stemper, M.E., Shukla, S.K., Reed, K.D. J. Clin. Microbiol. (2004) [Pubmed]
  3. Functional analyses of placental protein 13/galectin-13. Than, N.G., Pick, E., Bellyei, S., Szigeti, A., Burger, O., Berente, Z., Janaky, T., Boronkai, A., Kliman, H., Meiri, H., Bohn, H., Than, G.N., Sumegi, B. Eur. J. Biochem. (2004) [Pubmed]
  4. A novel approach to first-trimester screening for early pre-eclampsia combining serum PP-13 and Doppler ultrasound. Nicolaides, K.H., Bindra, R., Turan, O.M., Chefetz, I., Sammar, M., Meiri, H., Tal, J., Cuckle, H.S. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. (2006) [Pubmed]
  5. Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden Crystal protein. Than, N.G., Sumegi, B., Than, G.N., Berente, Z., Bohn, H. Placenta (1999) [Pubmed]
  6. Placental protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies. Burger, O., Pick, E., Zwickel, J., Klayman, M., Meiri, H., Slotky, R., Mandel, S., Rabinovitch, L., Paltieli, Y., Admon, A., Gonen, R. Placenta (2004) [Pubmed]
  7. Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13). Visegrády, B., Than, N.G., Kilár, F., Sümegi, B., Than, G.N., Bohn, H. Protein Eng. (2001) [Pubmed]
  8. Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17). Bohn, H., Kraus, W., Winckler, W. Oncodev. Biol. Med. (1983) [Pubmed]
WikiGenes - Universities