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Gene Review:

Foxd3 - forkhead box D3

Rattus norvegicus

Synonyms: CWH3, Forkhead box protein D3, Genesis, HFH-2, HNF3/FH transcription factor genesis, ...

Solomon, L.Z. et al., Marsden, I. et al., Sontag, T.A. et al., Overdier, D.G. et al., Sievers, J. et al.

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High impact information on Foxd3

In this report, we have determined the preferred DNA-binding consensus sequence for the HNF-3 beta protein as well as for two divergent family members, HFH-1 and HFH-2 [1].
We report our findings of an NMR structural study performed on an HNF-3/fkh family member (Genesis, formerly HFH-2) and compare it to that of another family member (HNF-3gamma) complexed to DNA and determined by X-ray crystallography [2].
6-OHDA-induced ectopia of external granule cells in the subarachnoid space covering the cerebellum. Genesis and topography [3].

Analytical, diagnostic and therapeutic context of Foxd3

Epidemiological studies have reported that the risk of developing schizophrenia increases with the number of genes one shares with patients suffering from schizophrenia [Gottesman Schizophrenia Genesis, New York: Freeman; 1991] [4].
MATERIALS AND METHODS: The particle size of three types of particulate unphysiological bioinjectable material, i.e. Urocol (Genesis Medical, Ltd., London), Macroplastiquetrade mark (Uroplasty Ltd., Reading, UK) and Urethrin (Mentor Medical Systems, Wantage, UK) was analysed using phase-contrast light microscopy and confocal microscopy [5].

References

The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix. Overdier, D.G., Porcella, A., Costa, R.H. Mol. Cell. Biol. (1994) [Pubmed]
Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins. Marsden, I., Jin, C., Liao, X. J. Mol. Biol. (1998) [Pubmed]
6-OHDA-induced ectopia of external granule cells in the subarachnoid space covering the cerebellum. Genesis and topography. Sievers, J., Mangold, U., Berry, M. Cell Tissue Res. (1983) [Pubmed]
Removal of short-term isolation stress differentially influences prepulse inhibition in APO-SUS and APO-UNSUS rats. Sontag, T.A., Cools, A.R., Ellenbroek, B.A. Behav. Brain Res. (2003) [Pubmed]
Nonhomologous bioinjectable materials in urology: 'size matters'? Solomon, L.Z., Birch, B.R., Cooper, A.J., Davies, C.L., Holmes, S.A. BJU international. (2000) [Pubmed]

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FOXD3	Bos taurus
FOXD3	Canis lupus familiaris
foxd3	Danio rerio
FOXD3	Homo sapiens
FOXD3	Macaca mulatta
Foxd3	Mus musculus
FOXD3	Pan troglodytes
foxd3	Xenopus (Silurana) tropicalis

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