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Gene Review

Gzmm  -  granzyme M (lymphocyte met-ase 1)

Rattus norvegicus

Synonyms: Granzyme M, Met-ase, Natural killer cell granular protease, RNK-Met-1
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Disease relevance of Gzmm


High impact information on Gzmm


Biological context of Gzmm

  • We have prepared nested deletions from approximately 3.3 kb of the 5'-flanking region of the RNK-Met-1 gene, and inserted these upstream of the chloramphenicol acetyltransferase (CAT) reporter gene [1].
  • These data are consistent with the NK cell-specific expression of RNK-Met-1 and suggest the potential utility of this gene promoter in the development of transgene models of NK cell biology in vivo [1].
  • The RNK-Met-1 gene comprises 5 exons and spans approximately 5.2 kilobases (kb), exhibiting a similar structural organization to a class of CTL-serine proteases with protease catalytic residues encoded near the borders of exons 2, 3, and 5 [1].
  • The 5'-flanking region of the RNK-Met-1 gene contains a number of putative promoter and enhancer regulatory elements and shares several regions of homology with the 5'-flanking region of the mouse perforin gene [1].

Anatomical context of Gzmm

  • These data indicate that RNK-Met-1 is a serine protease with unique activity that is expressed in the granules of large granular lymphocytes [4].

Associations of Gzmm with chemical compounds

  • We determined the effects on lysis and the second order inhibition rate constants for five granule protease activities: ly-tryptase, ly-chymase, Met-ase (methionine cleaving), Ser-ase (serine cleaving) and Asp-ase (aspartic acid cleaving) [5].


  1. Cloning and characterization of a novel NK cell-specific serine protease gene and its functional 5'-flanking sequences. Smyth, M.J., Hulett, M.D., Thia, K.Y., Young, H.A., Sayers, T.J., Carter, C.R., Trapani, J.A. Immunogenetics (1995) [Pubmed]
  2. Serine proteases in rodent hippocampus. Davies, B.J., Pickard, B.S., Steel, M., Morris, R.G., Lathe, R. J. Biol. Chem. (1998) [Pubmed]
  3. Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells. Smyth, M.J., Sayers, T.J., Wiltrout, T., Powers, J.C., Trapani, J.A. J. Immunol. (1993) [Pubmed]
  4. Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia. Smyth, M.J., Wiltrout, T., Trapani, J.A., Ottaway, K.S., Sowder, R., Henderson, L.E., Kam, C.M., Powers, J.C., Young, H.A., Sayers, T.J. J. Biol. Chem. (1992) [Pubmed]
  5. Sulfonyl fluoride serine protease inhibitors inactivate RNK-16 lymphocyte granule proteases and reduce lysis by granule extracts and perforin. Ewoldt, G.R., Winkler, U., Powers, J.C., Hudig, D. Mol. Immunol. (1992) [Pubmed]
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