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Gene Review:

Fgf18 - fibroblast growth factor 18

Rattus norvegicus

Synonyms: FGF-18, Fibroblast growth factor 18

Antoine, M. et al., Hoshikawa, M. et al., Ellsworth, J.L. et al., Moore, E.E. et al.

Ellsworth, Garcia, Yu, Kindy,

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Disease relevance of Fgf18

The purpose of the present study was to evaluate whether FGF18 was neuroprotective in a rat model of cerebral ischemia and to compare the results with those obtained with FGF2 [1].
Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis [2].

Psychiatry related information on Fgf18

RESULTS: Infusion of FGF18 produced dose-dependent reductions in infarct volumes and improvements in tests of reference and working memory, motor ability, and exploratory behavior [1].

High impact information on Fgf18

Fgf18 expression was earlier reported in the liver, and we detected FGF18 expression in liver vascular and liver sinusoidal endothelial cells (LSECs), but not in hepatic parenchymal cells [3].
At this time, animals received bi-weekly intra-articular injections of FGF18 for 3 weeks, and the knee joints were then harvested for histologic examination [2].
FGF-18 was found to bind to FGF receptors (FGFRs)-3c and -2c but not to FGFR-1c, suggesting that FGF-18 acts on glial cells but not on neurons [4].
Therefore, we examined the mitogenic activity of FGF-18 for cultured rat astrocytes and microglia [4].
FGF-18 was found to have mitogenic activity for both astrocytes and microglia [4].

Anatomical context of Fgf18

Fibroblast growth factor-18 reduced infarct volumes and behavioral deficits after transient occlusion of the middle cerebral artery in rats [1].
FGF-18 is a neuron-derived glial cell growth factor expressed in the rat brain during early postnatal development [4].
FGF-18 was transiently expressed at the early postnatal stages in various regions of the rat brain including the cerebral cortex and hippocampus [4].

Analytical, diagnostic and therapeutic context of Fgf18

Starting 15 minutes after MCAo, FGF18 or FGF2 was administered by a 3-hour intravenous infusion [1].
We examined the expression of fibroblast growth factor-18 (FGF-18) in the rat brain during postnatal development by in situ hybridization [4].

References

Fibroblast growth factor-18 reduced infarct volumes and behavioral deficits after transient occlusion of the middle cerebral artery in rats. Ellsworth, J.L., Garcia, R., Yu, J., Kindy, M.S. Stroke (2003) [Pubmed]
Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Moore, E.E., Bendele, A.M., Thompson, D.L., Littau, A., Waggie, K.S., Reardon, B., Ellsworth, J.L. Osteoarthr. Cartil. (2005) [Pubmed]
Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. Antoine, M., Wirz, W., Tag, C.G., Gressner, A.M., Wycislo, M., Müller, R., Kiefer, P. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
FGF-18 is a neuron-derived glial cell growth factor expressed in the rat brain during early postnatal development. Hoshikawa, M., Yonamine, A., Konishi, M., Itoh, N. Brain Res. Mol. Brain Res. (2002) [Pubmed]

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FGF18	Bos taurus
FGF18	Canis lupus familiaris
fgf18a	Danio rerio
fgf18b	Danio rerio
FGF18	Gallus gallus
FGF18	Homo sapiens
Fgf18	Mus musculus

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