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Gene Review

FGF18  -  fibroblast growth factor 18

Homo sapiens

Synonyms: FGF-18, Fibroblast growth factor 18, UNQ420/PRO856, ZFGF5, zFGF5
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Disease relevance of FGF18


Psychiatry related information on FGF18


High impact information on FGF18

  • This result is consistent with Fgf17 and Fgf18 being expressed in the midbrain and not just in r1 as Fgf8 is [7].
  • Direct Interactions of Runx2 and Canonical Wnt Signaling Induce FGF18 [8].
  • Here we show that an essential regulator of bone development, FGF18, is a direct target of canonical Wnt signaling [8].
  • A single DNA binding site for the Wnt-dependent transcription factors TCF/Lef accounted for the stimulation of the fgf18 promoter in response to Wnt signaling [8].
  • Based on these and other experiments it has been proposed that FGF18 signals through FGFR3 to promote cartilage production by chondrocytes [9].

Biological context of FGF18


Anatomical context of FGF18

  • We further show that FGF18 is necessary for Vegf expression in hypertrophic chondrocytes and the perichondrium and is sufficient to induce Vegf expression in skeletal explants [1].
  • However, this delay in mineralization could not be simply explained by FGF18 signaling to osteoblasts [1].
  • Fgf18 expression was earlier reported in the liver, and we detected FGF18 expression in liver vascular and liver sinusoidal endothelial cells (LSECs), but not in hepatic parenchymal cells [10].
  • In the VSMC of rat aortic tissue and in HUASM cultured cells we could demonstrate FGF18 immunoreactivity in the nucleus of the cells [12].
  • Recombinant FGF18 stimulated DNA synthesis in primary hepatocytes, suggesting, that endothelial FGF18 might have a paracrine function in promoting growth of the parenchymal tissue [10].

Associations of FGF18 with chemical compounds

  • In addition, vitamin A, which is known to enhance alveolar development, elevated FGF-18 and elastin expressions in day 2 lungs, thus advancing the biological increase [13].

Other interactions of FGF18

  • In the present report, we confirmed by RT-PCR analysis that FGF18 is wildly expressed in the cardiovascular tissue, while FGF16 showed a more restricted expression pattern [10].
  • FGF18, FGF20 and SPRY4 are potent targets of the canonical WNT signaling pathway in the gastrointestinal tract [14].
  • Sequence comparison indicates that FGF-18 is conserved with the other FGFs and most homologous to FGF-8 among the FGF family members [15].
  • Studies mostly performed in rodents and chicken have demonstrated that FGF18 is a pleiotropic growth factor involved in the development of various organs, while there are no data supporting a direct role of FGF23 in cell proliferation or differentiation either in physiology or pathology in any species [6].

Analytical, diagnostic and therapeutic context of FGF18


  1. FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Liu, Z., Lavine, K.J., Hung, I.H., Ornitz, D.M. Dev. Biol. (2007) [Pubmed]
  2. Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex. Shimokawa, T., Furukawa, Y., Sakai, M., Li, M., Miwa, N., Lin, Y.M., Nakamura, Y. Cancer Res. (2003) [Pubmed]
  3. Comparative genomics on FGF8, FGF17, and FGF18 orthologs. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  4. Two animal models of retinal degeneration are rescued by recombinant adeno-associated virus-mediated production of FGF-5 and FGF-18. Green, E.S., Rendahl, K.G., Zhou, S., Ladner, M., Coyne, M., Srivastava, R., Manning, W.C., Flannery, J.G. Mol. Ther. (2001) [Pubmed]
  5. Time window of fibroblast growth factor-18-mediated neuroprotection after occlusion of the middle cerebral artery in rats. Ellsworth, J.L., Garcia, R., Yu, J., Kindy, M.S. J. Cereb. Blood Flow Metab. (2004) [Pubmed]
  6. Expression of fibroblast growth factors 18 and 23 during human embryonic and fetal development. Cormier, S., Leroy, C., Delezoide, A.L., Silve, C. Gene Expr. Patterns (2005) [Pubmed]
  7. FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Liu, A., Li, J.Y., Bromleigh, C., Lao, Z., Niswander, L.A., Joyner, A.L. Development (2003) [Pubmed]
  8. Direct Interactions of Runx2 and Canonical Wnt Signaling Induce FGF18. Reinhold, M.I., Naski, M.C. J. Biol. Chem. (2007) [Pubmed]
  9. Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. Davidson, D., Blanc, A., Filion, D., Wang, H., Plut, P., Pfeffer, G., Buschmann, M.D., Henderson, J.E. J. Biol. Chem. (2005) [Pubmed]
  10. Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. Antoine, M., Wirz, W., Tag, C.G., Gressner, A.M., Wycislo, M., Müller, R., Kiefer, P. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  11. Assignment of fibroblast growth factor 18 (FGF18) to human chromosome 5q34 by use of radiation hybrid mapping and fluorescence in situ hybridization. Whitmore, T.E., Maurer, M.F., Sexson, S., Raymond, F., Conklin, D., Deisher, T.A. Cytogenet. Cell Genet. (2000) [Pubmed]
  12. Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells. Antoine, M., Wirz, W., Tag, C.G., Mavituna, M., Emans, N., Korff, T., Stoldt, V., Gressner, A.M., Kiefer, P. Growth Factors (2005) [Pubmed]
  13. FGF-18 is upregulated in the postnatal rat lung and enhances elastogenesis in myofibroblasts. Chailley-Heu, B., Boucherat, O., Barlier-Mur, A.M., Bourbon, J.R. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  14. FGF signaling network in the gastrointestinal tract (review). Katoh, M., Katoh, M. Int. J. Oncol. (2006) [Pubmed]
  15. Human fibroblast growth factor-18 stimulates fibroblast cell proliferation and is mapped to chromosome 14p11. Hu, M.C., Wang, Y.P., Qiu, W.R. Oncogene (1999) [Pubmed]
  16. Comprehensive analysis of FGF and FGFR expression in skin: FGF18 is highly expressed in hair follicles and capable of inducing anagen from telogen stage hair follicles. Kawano, M., Komi-Kuramochi, A., Asada, M., Suzuki, M., Oki, J., Jiang, J., Imamura, T. J. Invest. Dermatol. (2005) [Pubmed]
  17. Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. Ohbayashi, N., Hoshikawa, M., Kimura, S., Yamasaki, M., Fukui, S., Itoh, N. J. Biol. Chem. (1998) [Pubmed]
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