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Gene Review:

LINC00312 - long intergenic non-protein coding RNA 312

Homo sapiens

Synonyms: ERR-10, ERR10, LMCD1DN, LOH3CR2A, Loss of heterozygosity 3 chromosomal region 2 gene A protein, ...

Zhang, X.M. et al., Tan, C. et al., Xie, Y. et al., Meng, Q. et al., Tan, C. et al.

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Disease relevance of LOH3CR2A

In addition, the expression levels of NAG-7, and BRD7 did not alter in gastric and colorectal cancers [1].

High impact information on LOH3CR2A

We have demonstrated, through immunoprecipitation, Western blot and GST pull-down assays, that ERR-10 associates with ER-alpha [2].
Moreover, ERR-10 decreased 17beta-estrodial-induced activation of ER-alpha transcriptional activity in transient transfection assays of mammalian cells [2].
Estrogen modulation of estrogen-responsive gene expression was markedly blocked by ERR-10 [2].
AIM: NGX6, NAG-7 and BRD7 genes are tumor related genes, which have been newly cloned by positional candidate cloning strategy [1].
Furthermore, the expression of cyclin D1 and E decreased in NAG7 transfected HNE1 cells [3].

Biological context of LOH3CR2A

These results suggest that ERR-10 is a novel mediator in ER transcriptional activation [2].
CONCLUSION: NAG7 gene re-expression could inhibit overproliferation of NPC cell by delaying the progression of G1 into S in cell cycle and inducing cell apoptosis [3].
This study was designed to investigate the potential effect of NAG7 on the cell cycle and apoptosis of nasopharyngeal carcinoma cell line HNE1 and its molecular mechanism [3].
RESULTS: A novel gene located at chromosome 3p25.3 was obtained and named NAG-7 [4].
Its 1677 bp full length cDNA had a potential open reading frame predicting a 94 amino acid protein with a molecular weight of 11,023.87 Dalton. Analysis of the NAG-7 gene showed that it was a transmembrane protein containing a protein kinase C phosphorylation site and a myristyl site [4].

Associations of LOH3CR2A with chemical compounds

METHODS: NAG7 gene was introduced into HNE1 cells using lipofectin transfection technique [3].
The NAG7 eukaryotic expression vector was constructed and transfected into NPC cell line HNE1 with liposome [5].

Other interactions of LOH3CR2A

This seems to suggest that NAG-7 and BRD7 genes may not play a role in gastric and colorectal carcinogenesis [1].
This study was designed to investigate the expression levels of NGX6, NAG-7 and BRD7 genes in human gastric and colorectal cancer tissues, and their corresponding normal tissues, and to investigate whether these genes play a role in the pathogenesis of gastric and colorectal cancers [1].
BACKGROUND & OBJECTIVE: NPC-associated gene NAG7 was a novel candidate tumor suppressor gene associated with nasopharyngeal carcinoma cloned in our laboratory [3].

Analytical, diagnostic and therapeutic context of LOH3CR2A

METHODS: Reverse transcription-polymerase chain reaction (RT-PCR), dot hybridization and Northern blot analysis were used to compare the expression levels of NGX6, NAG-7 and BRD7 genes in 34 gastric cancer tissues and 34 colorectal cancer tissues with their corresponding normal tissues of the same patients, respectively [1].
The expression level of NAG7 gene was analyzed by Northern blot [3].
Molecular cloning and characterization of NAG-7: a novel gene downregulated in human nasopharyngeal carcinoma [4].

References

Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer. Zhang, X.M., Wang, X.Y., Sheng, S.R., Wang, J.R., Li, J. World J. Gastroenterol. (2003) [Pubmed]
ERR-10: a new repressor in transcriptional signaling activation of estrogen receptor-alpha. Meng, Q., Zhao, Z., Yan, M., Zhou, L., Li, J., Kitt, C., Bin, G., Fan, S. FEBS Lett. (2004) [Pubmed]
Effects of NPC-associated gene NAG7 on cell cycle and apoptosis in nasopharyngeal carcinoma cells. Tan, C., Peng, C., Huang, Y.C., Zhang, Q.H., Tang, K., Li, X.L., Li, G.Y. Ai Zheng (2002) [Pubmed]
Molecular cloning and characterization of NAG-7: a novel gene downregulated in human nasopharyngeal carcinoma. Xie, Y., Bin, L., Yang, J., Li, Z., Yu, Y., Zhang, X., Cao, L., Li, G. Chin. Med. J. (2001) [Pubmed]
Proteomic analysis of differential protein expression in human nasopharyngeal carcinoma cells induced by NAG7 transfection. Tan, C., Li, J., Wang, J., Xiang, Q., Zhang, X., Dong, L., Shen, S., Liang, S., Li, G. Proteomics (2002) [Pubmed]

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