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Chemical Compound Review

Tryptase     ethanoic acid; tert-butyl N-[(1S)-1-[[(1S)...

Synonyms: AC1NSKPU, 16060-EP2277848A1, 16060-EP2281563A1, 16060-EP2281815A1, 16060-EP2289887A2, ...
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Disease relevance of N-[(1S)-1-[[(1S)-1-[[(1S)-4-guanidino-1-[(5-methyl-2-oxo-chromen-7-yl)carbamoyl]butyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-phenyl-ethyl]carbamic acid tert-butyl ester

 

Psychiatry related information on N-[(1S)-1-[[(1S)-1-[[(1S)-4-guanidino-1-[(5-methyl-2-oxo-chromen-7-yl)carbamoyl]butyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-phenyl-ethyl]carbamic acid tert-butyl ester

 

High impact information on N-[(1S)-1-[[(1S)-1-[[(1S)-4-guanidino-1-[(5-methyl-2-oxo-chromen-7-yl)carbamoyl]butyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-phenyl-ethyl]carbamic acid tert-butyl ester

 

Chemical compound and disease context of N-[(1S)-1-[[(1S)-1-[[(1S)-4-guanidino-1-[(5-methyl-2-oxo-chromen-7-yl)carbamoyl]butyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-phenyl-ethyl]carbamic acid tert-butyl ester

 

Biological context of N-[(1S)-1-[[(1S)-1-[[(1S)-4-guanidino-1-[(5-methyl-2-oxo-chromen-7-yl)carbamoyl]butyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-phenyl-ethyl]carbamic acid tert-butyl ester

 

Anatomical context of N-[(1S)-1-[[(1S)-1-[[(1S)-4-guanidino-1-[(5-methyl-2-oxo-chromen-7-yl)carbamoyl]butyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-phenyl-ethyl]carbamic acid tert-butyl ester

 

Associations of N-[(1S)-1-[[(1S)-1-[[(1S)-4-guanidino-1-[(5-methyl-2-oxo-chromen-7-yl)carbamoyl]butyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-phenyl-ethyl]carbamic acid tert-butyl ester with other chemical compounds

 

Gene context of N-[(1S)-1-[[(1S)-1-[[(1S)-4-guanidino-1-[(5-methyl-2-oxo-chromen-7-yl)carbamoyl]butyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-phenyl-ethyl]carbamic acid tert-butyl ester

  • One mast-cell product, the serine protease tryptase, is known to activate protease-activated receptor 2 (PAR2) and cause proliferation of fibroblasts [23].
  • We found that recombinant tryptase, human mast-cell (HMC-1) supernatant, which contains tryptase, and the PAR2-activating peptide SLIGKV exert fibroproliferative actions in human fibroblasts [23].
  • Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders [23].
  • Furthermore, in these 3 patients, spontaneous, MGF-independent growth of mast cells along with spontaneous synthesis of tryptase was demonstrable in long-term culture [8].
  • Because MMCP-5 is a chymase and MMCP-6 a tryptase, there was a possibility that the difference in regulation mechanisms was associated with their different characteristics as proteases [24].
 

Analytical, diagnostic and therapeutic context of N-[(1S)-1-[[(1S)-1-[[(1S)-4-guanidino-1-[(5-methyl-2-oxo-chromen-7-yl)carbamoyl]butyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-phenyl-ethyl]carbamic acid tert-butyl ester

References

  1. Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. Schwartz, L.B., Metcalfe, D.D., Miller, J.S., Earl, H., Sullivan, T. N. Engl. J. Med. (1987) [Pubmed]
  2. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Steinhoff, M., Vergnolle, N., Young, S.H., Tognetto, M., Amadesi, S., Ennes, H.S., Trevisani, M., Hollenberg, M.D., Wallace, J.L., Caughey, G.H., Mitchell, S.E., Williams, L.M., Geppetti, P., Mayer, E.A., Bunnett, N.W. Nat. Med. (2000) [Pubmed]
  3. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Coussens, L.M., Raymond, W.W., Bergers, G., Laig-Webster, M., Behrendtsen, O., Werb, Z., Caughey, G.H., Hanahan, D. Genes Dev. (1999) [Pubmed]
  4. Effects of interferon-alpha2b treatment on ex vivo differentiation of mast cells from circulating progenitor cells in a patient with systemic mastocytosis. Schernthaner, G.H., Spanblöchl, E., Sperr, W.R., Sillaber, C., Semper, H., Jurecka, W., Hagen, W., Wolff, K., Chott, A., Lechner, K., Valent, P. Ann. Hematol. (2000) [Pubmed]
  5. Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Steinhoff, M., Buddenkotte, J., Shpacovitch, V., Rattenholl, A., Moormann, C., Vergnolle, N., Luger, T.A., Hollenberg, M.D. Endocr. Rev. (2005) [Pubmed]
  6. Human endothelial cells regulate survival and proliferation of human mast cells. Mierke, C.T., Ballmaier, M., Werner, U., Manns, M.P., Welte, K., Bischoff, S.C. J. Exp. Med. (2000) [Pubmed]
  7. The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. Kawabata, A., Kinoshita, M., Nishikawa, H., Kuroda, R., Nishida, M., Araki, H., Arizono, N., Oda, Y., Kakehi, K. J. Clin. Invest. (2001) [Pubmed]
  8. Kit ligand/mast cell growth factor-independent differentiation of mast cells in myelodysplasia and chronic myeloid leukemic blast crisis. Valent, P., Spanblöchl, E., Bankl, H.C., Sperr, W.R., Marosi, C., Pirc-Danoewinata, H., Virgolini, I., Eichler, H.G., Agis, H., Sillaber, C. Blood (1994) [Pubmed]
  9. Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness. Klion, A.D., Noel, P., Akin, C., Law, M.A., Gilliland, D.G., Cools, J., Metcalfe, D.D., Nutman, T.B. Blood (2003) [Pubmed]
  10. Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome. Klion, A.D., Robyn, J., Akin, C., Noel, P., Brown, M., Law, M., Metcalfe, D.D., Dunbar, C., Nutman, T.B. Blood (2004) [Pubmed]
  11. Induction of C3 and CCL2 by C3a in Keratinocytes: A Novel Autocrine Amplification Loop of Inflammatory Skin Reactions. Purwar, R., Wittmann, M., Zwirner, J., Oppermann, M., Kracht, M., Dittrich-Breiholz, O., Gutzmer, R., Werfel, T. J. Immunol. (2006) [Pubmed]
  12. Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Cenac, N., Coelho, A.M., Nguyen, C., Compton, S., Andrade-Gordon, P., MacNaughton, W.K., Wallace, J.L., Hollenberg, M.D., Bunnett, N.W., Garcia-Villar, R., Bueno, L., Vergnolle, N. Am. J. Pathol. (2002) [Pubmed]
  13. Cloning and characterization of complementary DNA for human tryptase. Miller, J.S., Westin, E.H., Schwartz, L.B. J. Clin. Invest. (1989) [Pubmed]
  14. Mast cell tryptase is a mitogen for cultured fibroblasts. Ruoss, S.J., Hartmann, T., Caughey, G.H. J. Clin. Invest. (1991) [Pubmed]
  15. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis. Schwartz, L.B., Yunginger, J.W., Miller, J., Bokhari, R., Dull, D. J. Clin. Invest. (1989) [Pubmed]
  16. Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs. Sekizawa, K., Caughey, G.H., Lazarus, S.C., Gold, W.M., Nadel, J.A. J. Clin. Invest. (1989) [Pubmed]
  17. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. Corvera, C.U., Déry, O., McConalogue, K., Böhm, S.K., Khitin, L.M., Caughey, G.H., Payan, D.G., Bunnett, N.W. J. Clin. Invest. (1997) [Pubmed]
  18. A novel heparin-dependent processing pathway for human tryptase. Autocatalysis followed by activation with dipeptidyl peptidase I. Sakai, K., Ren, S., Schwartz, L.B. J. Clin. Invest. (1996) [Pubmed]
  19. The hypereosinophilic syndromes: still more heterogeneity. Gleich, G.J., Leiferman, K.M. Curr. Opin. Immunol. (2005) [Pubmed]
  20. Recombinant human stem cell factor stimulates differentiation of mast cells from dispersed human fetal liver cells. Irani, A.M., Nilsson, G., Miettinen, U., Craig, S.S., Ashman, L.K., Ishizaka, T., Zsebo, K.M., Schwartz, L.B. Blood (1992) [Pubmed]
  21. Intrahepatic mast cells in chronic liver diseases. Farrell, D.J., Hines, J.E., Walls, A.F., Kelly, P.J., Bennett, M.K., Burt, A.D. Hepatology (1995) [Pubmed]
  22. Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients. Rozniecki, J.J., Hauser, S.L., Stein, M., Lincoln, R., Theoharides, T.C. Ann. Neurol. (1995) [Pubmed]
  23. Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders. Frungieri, M.B., Weidinger, S., Meineke, V., Köhn, F.M., Mayerhofer, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  24. Deficient transcription of mouse mast cell protease 4 gene in mutant mice of mi/mi genotype. Jippo, T., Lee, Y.M., Katsu, Y., Tsujino, K., Morii, E., Kim, D.K., Kim, H.M., Kitamura, Y. Blood (1999) [Pubmed]
  25. A human lung mast cell chymotrypsin-like enzyme. Identification and partial characterization. Wintroub, B.U., Kaempfer, C.E., Schechter, N.M., Proud, D. J. Clin. Invest. (1986) [Pubmed]
  26. Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. Cairns, J.A., Walls, A.F. J. Clin. Invest. (1997) [Pubmed]
  27. Stem cell factor induction is associated with mast cell accumulation after canine myocardial ischemia and reperfusion. Frangogiannis, N.G., Perrard, J.L., Mendoza, L.H., Burns, A.R., Lindsey, M.L., Ballantyne, C.M., Michael, L.H., Smith, C.W., Entman, M.L. Circulation (1998) [Pubmed]
  28. Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia. Sperr, W.R., Jordan, J.H., Baghestanian, M., Kiener, H.P., Samorapoompichit, P., Semper, H., Hauswirth, A., Schernthaner, G.H., Chott, A., Natter, S., Kraft, D., Valenta, R., Schwartz, L.B., Geissler, K., Lechner, K., Valent, P. Blood (2001) [Pubmed]
 
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