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Gene Review

Fbxw2  -  F-box and WD-40 domain protein 2

Mus musculus

Synonyms: 2700071L08Rik, F-box and WD-40 domain-containing protein 2, F-box/WD repeat-containing protein 2, FBW2, Fwd2, ...
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High impact information on Fbxw2

  • Visualization of canine mesenteric venules by intravital microscopy showed that administration of MD6 resulted in a marked inhibition in the number of rolling leukocytes (18.96 +/- 9.92 v 156.40 +/- 19.50 leukocytes/min, P < .05; 88.3% +/- 6.0% inhibition) [1].
  • One of the hybridomas generated, MD6, was shown by enzyme-linked immunosorbent assay and by flow cytometry to bind preferentially to stimulated platelets and to completely prevent binding of stimulated platelets to neutrophils [1].
  • Comparison of the genomic organization of Fbxw6, which is located on mouse chromosome 3.3E3, with that of mouse Fbxw1, Fbxw2, and Fbxw4 showed only a low level of similarity, indicating that these genes diverged relatively early and thereafter evolved independently [2].
  • A coimmunoprecipitation assay has revealed the in vivo interaction between Skp1 and Fwd2 through the F-box domain [3].
  • Fwd2 cDNA contains 1890 bp with a 1362-bp open reading frame and encodes an approximately 51.5-kDa protein [3].

Biological context of Fbxw2


Anatomical context of Fbxw2


Analytical, diagnostic and therapeutic context of Fbxw2


  1. P-selectin mediates spontaneous leukocyte rolling in vivo. Doré, M., Korthuis, R.J., Granger, D.N., Entman, M.L., Smith, C.W. Blood (1993) [Pubmed]
  2. Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. Maruyama, S., Hatakeyama, S., Nakayama, K., Ishida, N., Kawakami, K., Nakayama, K. Genomics (2001) [Pubmed]
  3. Structure and expression of the gene encoding mouse F-box protein, Fwd2. Miura, M., Hatakeyama, S., Hattori, K., Nakayama, K. Genomics (1999) [Pubmed]
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