The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tep1  -  telomerase associated protein 1

Rattus norvegicus

Synonyms: Telomerase protein 1, Telomerase protein component 1, Telomerase-associated protein 1, Tlp1, p230, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tep1


High impact information on Tep1

  • The cells maintain high telomerase activity and p53- and Rb-dependent cell cycle checkpoint responses, and serum or genotoxic drugs induce them to acquire a senescence-like phenotype [5].
  • A protein complex involved in apolipoprotein B (apoB) RNA editing, referred to as AUX240 (auxiliary factor containing p240), has been identified through the production of monoclonal antibodies against in vitro assembled 27S editosomes [6].
  • However, mammary glands obtained from pregnant rats exhibited telomerase activity comparable to that found in the tumors, possibly reflecting the high epithelial content of these tissues [1].
  • Indeed, isolated epithelial cells from virgin and pregnant mammary glands and from carcinomas had similar telomerase activities [1].
  • Thus, telomerase activity is constitutive in the rat mammary epithelium and is not a unique characteristic of malignant transformation in this tissue [1].

Chemical compound and disease context of Tep1


Biological context of Tep1


Anatomical context of Tep1


Associations of Tep1 with chemical compounds


Regulatory relationships of Tep1


Other interactions of Tep1

  • While mutations of all putative Akt phosphorylation sites in telomerase reverse transcriptase (TERT) has no effect on telomerase activity, inhibition of MAP kinase signalling by PD98059 or U0126 abolishes NGF-induced telomerase down-regulation in a concentration-dependent manner [19].
  • This could mean that PARM-1 is involved, via increased telomerase activity, in a survival program enabling certain prostatic cells to resist apoptosis, thus conferring a selective advantage to pre-cancerous or cancerous cells [20].
  • AIM: Initial report on the in situ examination of the mRNA expression of transforming growth factor betas (TGFbetas), TGFbeta type II receptor (TbetaRII) and telomerase activity in the experimental rat liver tissue during cholangiocarcinogenesis [21].
  • In situ detection of TGF betas, TGF beta receptor II mRNA and telomerase activity in rat cholangiocarcinogenesis [21].
  • The increase in telomerase activity and trophic effects of BDNF and sAPP are mediated by phosphatidylinositol-3 kinase and p42/p44 MAP kinases [17].

Analytical, diagnostic and therapeutic context of Tep1


  1. Telomerase activity in the normal and neoplastic rat mammary gland. Varon, D., Jiang, C., Hedican, C., Dome, J.S., Umbricht, C.B., Carey, L.A., Thompson, H.J., Sukumar, S. Cancer Res. (1997) [Pubmed]
  2. Anti-apoptotic role of telomerase in pheochromocytoma cells. Fu, W., Begley, J.G., Killen, M.W., Mattson, M.P. J. Biol. Chem. (1999) [Pubmed]
  3. Suppression of cell proliferation and telomerase activity in 4-(hydroxyphenyl)retinamide-treated mammary tumors. Bednarek, A., Shilkaitis, A., Green, A., Lubet, R., Kelloff, G., Christov, K., Aldaz, C.M. Carcinogenesis (1999) [Pubmed]
  4. Regulation of telomerase activity in rat lung fibroblasts. Liu, T., Nozaki, Y., Phan, S.H. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  5. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells. Tang, D.G., Tokumoto, Y.M., Apperly, J.A., Lloyd, A.C., Raff, M.C. Science (2001) [Pubmed]
  6. An auxiliary factor containing a 240-kDa protein complex is involved in apolipoprotein B RNA editing. Schock, D., Kuo, S.R., Steinburg, M.F., Bolognino, M., Sparks, J.D., Sparks, C.E., Smith, H.C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  7. Telomerase activity correlates with growth of transplantable osteosarcomas in rats treated with cis-diammine dichloroplatinum or the angiogenesis inhibitor AGM-1470. Kido, A., Tsujiuchi, T., Morishita, T., Tsutsumi, M., Takahama, M., Miyauchi, Y., Mii, Y., Tamai, S., Konishi, Y. Jpn. J. Cancer Res. (1998) [Pubmed]
  8. A subcellular distribution of estrogen receptor-alpha is changed during artificially induced senescence of PC12 pheochromocytoma cells. Lee, E., Mun, G.H., Oh, C.S., Chung, Y.H., Cha, C.L., Lee, Y.S., Shin, D.H. Neurosci. Lett. (2004) [Pubmed]
  9. Reversal of hepatoma cells resistance to anticancer drugs is correlated to cell proliferation kinetics, telomere length and telomerase activity. Chau, N.P., Deschatrette, J., Wolfrom, C. Anticancer Res. (2005) [Pubmed]
  10. Odontoblast cells immortalized by telomerase produce mineralized dentin-like tissue both in vitro and in vivo. Hao, J., Narayanan, K., Ramachandran, A., He, G., Almushayt, A., Evans, C., George, A. J. Biol. Chem. (2002) [Pubmed]
  11. Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFbeta. Hu, B., Tack, D.C., Liu, T., Wu, Z., Ullenbruch, M.R., Phan, S.H. Oncogene (2006) [Pubmed]
  12. Constitutive telomerase activity in cells with tissue-renewing potential from estrogen-regulated rat tissues. Bednarek, A.K., Chu, Y., Aldaz, C.M. Oncogene (1998) [Pubmed]
  13. Telomerase activity in normal adult Brown Norway rat seminal vesicle: regional distribution and age-dependent changes. Banerjee, P.P., Banerjee, S., Zirkin, B.R., Brown, T.R. Endocrinology (1998) [Pubmed]
  14. Repression of in vivo growth of Myc/Ras transformed tumor cells by Mad1. Cerni, C., Skrzypek, B., Popov, N., Sasgary, S., Schmidt, G., Larsson, L.G., Lüscher, B., Henriksson, M. Oncogene (2002) [Pubmed]
  15. Lobe-specific telomerase activity in the intact adult brown Norway rat prostate and its regional distribution within the prostatic ducts. Banerjee, P.P., Banerjee, S., Zirkin, B.R., Brown, T.R. Endocrinology (1998) [Pubmed]
  16. Telomerase is activated in the prostate and seminal vesicles of the castrated rat. Meeker, A.K., Sommerfeld, H.J., Coffey, D.S. Endocrinology (1996) [Pubmed]
  17. Telomerase mediates the cell survival-promoting actions of brain-derived neurotrophic factor and secreted amyloid precursor protein in developing hippocampal neurons. Fu, W., Lu, C., Mattson, M.P. J. Neurosci. (2002) [Pubmed]
  18. Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells. Ogawa, D., Nomiyama, T., Nakamachi, T., Heywood, E.B., Stone, J.F., Berger, J.P., Law, R.E., Bruemmer, D. Circ. Res. (2006) [Pubmed]
  19. Telomerase down-regulation does not mediate PC12 pheochromocytoma cell differentiation induced by NGF, but requires MAP kinase signalling. Li, H., Pinto, A.R., Duan, W., Li, J., Toh, B.H., Liu, J.P. J. Neurochem. (2005) [Pubmed]
  20. Prostatic androgen repressed message-1 (PARM-1) may play a role in prostatic cell immortalisation. Cornet, A.M., Hanon, E., Reiter, E.R., Bruyninx, M., Nguyen, V.H., Hennuy, B.R., Hennen, G.P., Closset, J.L. Prostate (2003) [Pubmed]
  21. In situ detection of TGF betas, TGF beta receptor II mRNA and telomerase activity in rat cholangiocarcinogenesis. Lu, J.P., Mao, J.Q., Li, M.S., Lu, S.L., Hu, X.Q., Zhu, S.N., Nomura, S. World J. Gastroenterol. (2003) [Pubmed]
  22. Telomerase activity in rat liver allografts. Goto, S., Lin, Y.C., Lai, C.Y., Lee, C.M., Pan, T.L., Lord, R., Chiang, K.C., Tseng, H.P., Lin, C.L., Cheng, Y.F., Yokoyama, H., Kitano, S., Chen, C.L. Transplantation (2000) [Pubmed]
WikiGenes - Universities