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Gene Review

acvr1l  -  activin A receptor, type I like

Danio rerio

Synonyms: SO:0000704, acvr1, alk2, alk8, alk8sum, ...
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High impact information on acvr1

  • A much stronger dorsalization, similar to that of bmp2b/swirl and bmp7/snailhouse mutants, however, is obtained by inhibiting both maternally and zygotically supplied alk8 gene products with morpholino antisense oligonucleotides [1].
  • The phenotype of laf mutants and alk8 morphants can be rescued by injected mRNA encoding Alk8 or the Bmp-regulated transcription factor Smad5, but not by mRNA encoding Bmp2b or Bmp7 [1].
  • We rescued the laf dorsalized mutant phenotype by alk8 mRNA injection and generated homozygous laf/alk8 mothers to investigate the maternal role of Laf/Alk8 activity [2].
  • We show here that the Bmp receptor lost-a-fin/alk8 is required for rostral pu.1 expression and myelopoiesis, identifying an early genetic event that distinguishes between the induction of anterior and posterior hematopoiesis [3].
  • Here, we present evidence that alk8 is required for neural crest cell (NCC) formation and that alk8 signaling gradients direct the proper patterning of premigratory NCCs [4].

Biological context of acvr1

  • Since Bmps play significant roles in tooth specification, initiation, and differentiation, we hypothesized that alk8 may play a role in directing the Bmp-mediated epithelial mesenchymal cell interactions regulating tooth development [5].
  • Single-strand conformation polymorphism (SSCP) analysis was used to map alk8 to zebrafish LG02 in a region demonstrating significant conserved synteny to Hsa2, and which contains the human alk2 gene, ACVRI [6].

Anatomical context of acvr1

  • We also demonstrate that patterning defects in premigratory NCCs, induced by alk8 misexpression, correlate with subsequent defects in NCC-derived pharyngeal arch cartilages [4].
  • Our results provide insight into alk8-mediated BMP signaling gradients and the establishment of premigratory NCC mediolateral positioning, and extend the model for BMP patterning of the neural crest to include that of NCC-derived pharyngeal arch cartilages [4].

Analytical, diagnostic and therapeutic context of acvr1

  • Functional characterization of alk8 was performed using microinjection studies of constitutively active (CA), kinase modified/dominant negative (DN), and truncated alk8 mRNAs [6].


  1. The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. Bauer, H., Lele, Z., Rauch, G.J., Geisler, R., Hammerschmidt, M. Development (2001) [Pubmed]
  2. Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation. Mintzer, K.A., Lee, M.A., Runke, G., Trout, J., Whitman, M., Mullins, M.C. Development (2001) [Pubmed]
  3. Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish. Hogan, B.M., Layton, J.E., Pyati, U.J., Nutt, S.L., Hayman, J.W., Varma, S., Heath, J.K., Kimelman, D., Lieschke, G.J. Curr. Biol. (2006) [Pubmed]
  4. Alk8 is required for neural crest cell formation and development of pharyngeal arch cartilages. Payne-Ferreira, T.L., Yelick, P.C. Dev. Dyn. (2003) [Pubmed]
  5. Regulation of tooth development by the novel type I TGFbeta family member receptor Alk8. Payne, T.L., Skobe, Z., Yelick, P.C. J. Dent. Res. (2001) [Pubmed]
  6. Functional characterization and genetic mapping of alk8. Payne, T.L., Postlethwait, J.H., Yelick, P.C. Mech. Dev. (2001) [Pubmed]
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