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Gene Review

Vps26a  -  vacuolar protein sorting 26 homolog A (yeast)

Mus musculus

Synonyms: AA407240, H beta 58, H58 protein, HB58, Vacuolar protein sorting-associated protein 26A, ...
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High impact information on Vps26a

  • By Day 12, the fetal vasculature extended into the placental labyrinth, and the erythroid stem cells continued to strongly express H beta 58 [1].
  • The expression pattern of H beta maternal and fetal placental tissues and its early expression in fetal erythroid stem cells during formation and maturation of the chorioallantoic placenta suggest that H beta 58 plays key roles in the regulatory networks that control hematopoietic development and placentation [1].
  • Immunoreactive H beta 58 localized to erythroid cells within the developing fetal vasculature of the chorioallantoic primordia at Day 10 of pregnancy [1].
  • Immunodetection in the early postimplantation uterus (Days 6-8 of pregnancy) showed H beta 58 localized in the luminal and glandular epithelia and some stromal cells [1].
  • Stable cell lines (HRP/LRP) isolated from the rat labyrinthine placenta expressed H beta 58 mRNA and protein [1].

Anatomical context of Vps26a

  • Decidual cells at Day 6 of pregnancy expressed H beta 58, and by Day 9 of pregnancy, the protein localized throughout the maternal decidua [1].
  • H beta 58 protein expression was found in the uterine epithelium beginning from the peri-ovulatory stage [2].
  • H beta 58 mutant embryonic stem cells are clearly pluripotent but they appear to be more restricted in their developmental potential, suggesting that the H beta 58 gene product may be required by specific tissues of the embryo [3].


  1. Changes in the temporal and spatial expression of H beta 58 during formation and maturation of the chorioallantoic placenta in the Rat. Rider, V., Jones, S.R., Foster, R.T., Imakawa, K. Biol. Reprod. (2000) [Pubmed]
  2. Evidence of H beta 58, a gene involved in mammalian placental development, in the three-toed skink, Chalcides chalcides (Squamata: Scincidae), a viviparous placentotrophic reptile. Paulesu, L., Cateni, C., Romagnoli, R., Chellini, F., Angelini, F., Guarino, F.M., Rider, V., Imakawa, K., Bigliardi, E. Placenta (2001) [Pubmed]
  3. Use of embryonic stem cells to study mutations affecting postimplantation development in the mouse. Robertson, E.J., Conlon, F.L., Barth, K.S., Costantini, F., Lee, J.J. Ciba Found. Symp. (1992) [Pubmed]
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