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Gene Review

HLX  -  H2.0-like homeobox

Homo sapiens

Synonyms: H2.0-like homeobox protein, HB24, HLX1, Homeobox protein HB24, Homeobox protein HLX1
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High impact information on HLX1


Biological context of HLX1


Other interactions of HLX1

  • Real-time polymerase chain reaction quantitation showed reduced HLX1 mRNA levels with advancing gestation age (preterm control placentas, 27 to 35 weeks, 1.1 +/- 0.3, n = 13, versus term placentas 36 to 41 weeks, 0.74 +/- 0.02, n = 12, P < 0.005) [4].

Analytical, diagnostic and therapeutic context of HLX1


  1. PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus. Tsao, B.P., Cantor, R.M., Grossman, J.M., Shen, N., Teophilov, N.T., Wallace, D.J., Arnett, F.C., Hartung, K., Goldstein, R., Kalunian, K.C., Hahn, B.H., Rotter, J.I. J. Clin. Invest. (1999) [Pubmed]
  2. Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia. Jawad, M., Seedhouse, C.H., Russell, N., Plumb, M. Blood (2006) [Pubmed]
  3. Dinucleotide repeat polymorphism for HLX1 gene. Sander, A., Kennedy, M.A., Rayner, J.C., Murray, J.C. Hum. Mol. Genet. (1994) [Pubmed]
  4. Homeobox gene HLX1 expression is decreased in idiopathic human fetal growth restriction. Murthi, P., Doherty, V., Said, J., Donath, S., Brennecke, S.P., Kalionis, B. Am. J. Pathol. (2006) [Pubmed]
  5. Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q. Nishimura, D.Y., Purchio, A.F., Murray, J.C. Genomics (1993) [Pubmed]
  6. Genomic structure, promoter sequence, and revised translation of human homeobox gene HLX1. Kennedy, M.A., Rayner, J.C., Morris, C.M. Genomics (1994) [Pubmed]
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