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Gene Review:

HLX - H2.0-like homeobox

Homo sapiens

Synonyms: H2.0-like homeobox protein, HB24, HLX1, Homeobox protein HB24, Homeobox protein HLX1

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High impact information on HLX1

Similar TDT analyses of TGFB2 and HLX1 polymorphisms yielded no evidence for association with SLE [1].
We suggest that the HLX1 polymorphism has an effect on stem cell numbers, whereas an increased DNA repair capacity (RAD51) will suppress apoptosis, a genetic interaction that may increase the number of genomes at risk during cancer therapy [2].
Dinucleotide repeat polymorphism for HLX1 gene [3].
Homeobox gene HLX1 expression is decreased in idiopathic human fetal growth restriction [4].
Here, we investigated whether placental HLX1 expression levels are changed in placentas from idiopathic FGR pregnancies [4].

Biological context of HLX1

FGR-affected placentas had significantly lower levels of HLX1 expression compared with gestation age-matched controls (0.36 +/- 0.07 versus 1.05 +/- 0.2, n = 25, P < 0.001) [4].
Previously, we isolated the homeobox gene HLX1 and provided evidence for a regulatory role in normal placental development [4].
Finally, utilizing the polymorphisms described for TGFB2 and HLX1, we have been able to localize these genes within a framework map of the distal long arm of chromosome 1 and to study the linkage relationship between these two genes [5].
We also report the chromosomal localization of HLX1 to the long arm of human chromosome 1 [5].
The transcription initiation sites of HLX1 were identified, and DNA sequences upstream of these sites were established [6].

Other interactions of HLX1

Real-time polymerase chain reaction quantitation showed reduced HLX1 mRNA levels with advancing gestation age (preterm control placentas, 27 to 35 weeks, 1.1 +/- 0.3, n = 13, versus term placentas 36 to 41 weeks, 0.74 +/- 0.02, n = 12, P < 0.005) [4].

Analytical, diagnostic and therapeutic context of HLX1

Immunohistochemistry showed a qualitative decrease in HLX1 immunoreactivity in FGR-affected term placentas compared with controls [4].
Immunoblotting with a rabbit polyclonal HLX1 antibody revealed reduced levels of HLX1 in FGR-affected placentas compared with controls (481.07 +/- 12.3 versus 2766.7 +/- 30.3, n = 10, P < 0.001) [4].

References

PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus. Tsao, B.P., Cantor, R.M., Grossman, J.M., Shen, N., Teophilov, N.T., Wallace, D.J., Arnett, F.C., Hartung, K., Goldstein, R., Kalunian, K.C., Hahn, B.H., Rotter, J.I. J. Clin. Invest. (1999) [Pubmed]
Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia. Jawad, M., Seedhouse, C.H., Russell, N., Plumb, M. Blood (2006) [Pubmed]
Dinucleotide repeat polymorphism for HLX1 gene. Sander, A., Kennedy, M.A., Rayner, J.C., Murray, J.C. Hum. Mol. Genet. (1994) [Pubmed]
Homeobox gene HLX1 expression is decreased in idiopathic human fetal growth restriction. Murthi, P., Doherty, V., Said, J., Donath, S., Brennecke, S.P., Kalionis, B. Am. J. Pathol. (2006) [Pubmed]
Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q. Nishimura, D.Y., Purchio, A.F., Murray, J.C. Genomics (1993) [Pubmed]
Genomic structure, promoter sequence, and revised translation of human homeobox gene HLX1. Kennedy, M.A., Rayner, J.C., Morris, C.M. Genomics (1994) [Pubmed]

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HLX	Bos taurus
HLX	Canis lupus familiaris
hlx1	Danio rerio
HLX	Macaca mulatta
Hlx	Mus musculus
HLX	Pan troglodytes
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hlx	Xenopus (Silurana) tropicalis

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