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Gene Review

dx  -  deltex

Drosophila melanogaster

Synonyms: CG3929, DMDELTEX, Dmel\CG3929, Dx, Protein deltex
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High impact information on dx

  • Su(H) exhibits numerous allele-specific genetic interactions with Notch as well as with Delta, deltex, and mastermind [1].
  • Finally, blocking the N transportation from the plasma membrane to the late-endosome by a dominant-negative form of Rab5 inhibited the Dx-mediated activation of N signaling, suggesting that the accumulation of N in the late-endosome was required for the Dx-mediated Su(H)-independent N signaling [2].
  • Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling [2].
  • Notch (N) signaling is an evolutionarily conserved mechanism that regulates many cell-fate decisions. deltex (dx) encodes an E3-ubiquitin ligase that binds to the intracellular domain of N and positively regulates N signaling [2].
  • Consistent with this, the dx gene was required for the presence of N in the endocytic vesicles [2].

Biological context of dx


Anatomical context of dx


Associations of dx with chemical compounds

  • Here, we found that three motifs in Dx, a region that binds to Notch, a proline-rich motif and a RING-H2 finger, were required for this stabilization, although the relative activity of these variants in this assay did not always correspond to the severity of the rough-eye phenotype [8].

Regulatory relationships of dx

  • The Drosophila deltex gene regulates Notch signaling in a positive manner, and its gene product physically interacts with the intracellular domain of Notch through its N-terminal domain [4].

Other interactions of dx

  • This activity, mediated by Deltex (Dx), represses neural fate and is antagonized by elements of the Wingless (Wg)-signaling cascade to allow alternative cell fate choices [3].
  • We have determined the solution structure and dynamics of a pair of WW domains (WW3-4) from a Drosophila Nedd4 family protein called Suppressor of deltex (Su(dx)), a regulator of Notch receptor signaling [9].
  • Prior genetic studies have suggested a functional relationship between the product of the deltex gene and those of three of the so-called "neurogenic" loci, Notch, Delta and mastermind [10].


  1. The suppressor of hairless protein participates in notch receptor signaling. Fortini, M.E., Artavanis-Tsakonas, S. Cell (1994) [Pubmed]
  2. Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling. Hori, K., Fostier, M., Ito, M., Fuwa, T.J., Go, M.J., Okano, H., Baron, M., Matsuno, K. Development (2004) [Pubmed]
  3. Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Ramain, P., Khechumian, K., Seugnet, L., Arbogast, N., Ackermann, C., Heitzler, P. Curr. Biol. (2001) [Pubmed]
  4. Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling. Matsuno, K., Ito, M., Hori, K., Miyashita, F., Suzuki, S., Kishi, N., Artavanis-Tsakonas, S., Okano, H. Development (2002) [Pubmed]
  5. Down-regulation of Notch target gene expression by Suppressor of deltex. Mazaleyrat, S.L., Fostier, M., Wilkin, M.B., Aslam, H., Evans, D.A., Cornell, M., Baron, M. Dev. Biol. (2003) [Pubmed]
  6. The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase. Cornell, M., Evans, D.A., Mann, R., Fostier, M., Flasza, M., Monthatong, M., Artavanis-Tsakonas, S., Baron, M. Genetics (1999) [Pubmed]
  7. Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins. Wilkin, M.B., Carbery, A.M., Fostier, M., Aslam, H., Mazaleyrat, S.L., Higgs, J., Myat, A., Evans, D.A., Cornell, M., Baron, M. Curr. Biol. (2004) [Pubmed]
  8. Genetic regions that interact with loss- and gain-of-function phenotypes of deltex implicate novel genes in Drosophila Notch signaling. Hori, K., Fuwa, T.J., Seki, T., Matsuno, K. Mol. Genet. Genomics (2005) [Pubmed]
  9. The structure and dynamics of tandem WW domains in a negative regulator of notch signaling, Suppressor of deltex. Fedoroff, O.Y., Townson, S.A., Golovanov, A.P., Baron, M., Avis, J.M. J. Biol. Chem. (2004) [Pubmed]
  10. A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein. Busseau, I., Diederich, R.J., Xu, T., Artavanis-Tsakonas, S. Genetics (1994) [Pubmed]
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