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Gene Review

Cp36  -  Chorion protein 36

Drosophila melanogaster

Synonyms: CG1478, CP36, Chorion protein S36, Dmel\CG1478, Dms36, ...
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High impact information on Cp36

  • To determine if the sequences bound by the particles play a role in RNA processing, we have correlated the nascent transcript morphology of Drosophila chorion s36-1 and s38-1 genes with their nucleotide sequences [1].
  • We have fused various DNA sequences located upstream of the Drosophila melanogaster s36 chorion gene TATA box to a heterologous basal promoter and reporter gene (hsp70/lacZ) [2].
  • The results indicate that almost exclusively 5' flanking DNA regions of the early (s36) and late (s15) chorion genes suffice for conferring normal chorion developmental specificity (sex, tissue and temporal) on the reporter gene [3].
  • We propose a model for transcriptional regulation of s36 based on the prechoriogenic polarization of the follicular epithelium that surrounds the developing egg chamber [4].
  • Elements controlling follicular expression of the s36 chorion gene during Drosophila oogenesis [4].

Biological context of Cp36

  • The central domain of both proteins, which exhibits extensive sequence homology with the corresponding domains of Drosophila melanogaster proteins s36 and s38, is formed by tandem repeats of an octapeptide-X-X-X-Z-Z-Z-Z-Z- (where X = large hydrophobic residue and Z = beta-turn former residue) and its variants [5].
  • We have used low stringency screening with the Drosophila melanogaster s36 chorion gene to recover its homologue from genomic and cDNA libraries of the medfly, Ceratitis capitata [6].
  • Alignments of s36 sequences from three species show that, in addition to its regulatory conservation, the s36 gene is extensively conserved in sequence, in a region corresponding to a central protein domain, and in short regions of 5' flanking DNA that might correspond to cis-regulatory elements [6].
  • In the present work, we have sequenced one intron and surrounding coding sequences of 6 X-linked genes (chorion protein s36, elav, fused, runt, suppressor of sable and zeste) from 21 strains of wild-type Drosophila virilis (subgenus Drosophila) [7].

Anatomical context of Cp36


Other interactions of Cp36

  • Despite marked temporal differences in their accumulation profiles, s36 and s18, putative chorion proteins, were similarly distributed throughout the floor, pillars, and roof of the endochorion [8].
  • DNA fragments containing 5' flanking plus the entire 5' untranslated and the beginning of the coding region of either the s36 or the s15 chorion gene are able to confer on the reporter genes normal tissue as well as temporal specificity of expression, exclusively in the ovary of transformed female flies [9].


  1. RNP particles at splice junction sequences on Drosophila chorion transcripts. Osheim, Y.N., Miller, O.L., Beyer, A.L. Cell (1985) [Pubmed]
  2. Functional dissection of an early Drosophila chorion gene promoter: expression throughout the follicular epithelium is under spatially composite regulation. Tolias, P.P., Kafatos, F.C. EMBO J. (1990) [Pubmed]
  3. Both early and late Drosophila chorion gene promoters confer correct temporal, tissue and sex specificity on a reporter Adh gene. Romano, C.P., Bienz-Tadmor, B., Mariani, B.D., Kafatos, F.C. EMBO J. (1988) [Pubmed]
  4. Elements controlling follicular expression of the s36 chorion gene during Drosophila oogenesis. Tolias, P.P., Konsolaki, M., Halfon, M.S., Stroumbakis, N.D., Kafatos, F.C. Mol. Cell. Biol. (1993) [Pubmed]
  5. Tandemly repeating peptide motifs and their secondary structure in Ceratitis capitata eggshell proteins Ccs36 and Ccs38. Aggeli, A., Hamodrakas, S.J., Komitopoulou, K., Konsolaki, M. Int. J. Biol. Macromol. (1991) [Pubmed]
  6. The chorion genes of the medfly, Ceratitis capitata, I: Structural and regulatory conservation of the s36 gene relative to two Drosophila species. Konsolaki, M., Komitopoulou, K., Tolias, P.P., King, D.L., Swimmer, C., Kafatos, F.C. Nucleic Acids Res. (1990) [Pubmed]
  7. X chromosome DNA variation in Drosophila virilis. Vieira, J., Charlesworth, B. Proc. Biol. Sci. (1999) [Pubmed]
  8. Eggshell assembly in Drosophila: processing and localization of vitelline membrane and chorion proteins. Pascucci, T., Perrino, J., Mahowald, A.P., Waring, G.L. Dev. Biol. (1996) [Pubmed]
  9. Chorion gene cis-regulatory DNA restricts tissue specificity of reporter gene expression in transformed Drosophila. Bienz-Tadmor, B., Tolias, P., Stebbins-Boaz, B., Mariani, B.D., Gerbi, S.A., Kafatos, F.C. Chromosoma (1992) [Pubmed]
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