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Gene Review

Cp15  -  Chorion protein 15

Drosophila melanogaster

Synonyms: C.s15, CG6519, Chorion protein S15, Cs15, Dmel\CG6519, ...
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Disease relevance of Cp15

  • The carboxy-terminal PDZ domain-binding motif of the E6 proteins is in fact essential for transformation of rodent cells and induction of hyperplasia in E6-transgenic mouse skin [1].

High impact information on Cp15

  • These proteins are present in nuclear extracts of ovarian follicles, the tissue where s15 is expressed during development, and bind to specific elements of the promoter that have been shown by transformation analysis to be important for in vivo expression [2].
  • Gel mobility-shift assays have been used to identify proteins that bind specifically to the promoter region of the Drosophila s15 chorion gene [2].
  • However, initiation was nonrandom; the majority of initiations appeared to occur near the Bgl II site located between the s18 and s15 chorion genes [3].
  • The results indicate that almost exclusively 5' flanking DNA regions of the early (s36) and late (s15) chorion genes suffice for conferring normal chorion developmental specificity (sex, tissue and temporal) on the reporter gene [4].
  • We have determined the optimal binding site of partially purified bacterially produced CF1/USP by an in vitro selection procedure and also have characterized its binding to the follicular-specific chorion s15 promoter [5].

Biological context of Cp15

  • Moreover, a highly synergistically formed heterodimeric complex with the DNA-binding domain of EcR was observed on hsp27EcRE, but not on the native Usp response element from the chorion s15 gene promoter [6].
  • We present the nucleotide sequences of DNA segments that total 8.3 kb in length and include gene s15-1 from D. subobscura, D. virilis, and D. grimshawi as well as gene s19-1 from D. subobscura and D. grimshawi [7].
  • In the fourth, gene s15, significant alterations in the 5' flanking region may be responsible for its changed temporal regulation in C. capitata [8].
  • The highest number of dyad symmetries, reminiscent of sequences that function as viral replication origins, is found associated with the T- and A-rich regions between genes s18-1 and s15-1 [9].

Anatomical context of Cp15

  • The Drosophila s15 chorion gene is expressed only in the follicular epithelium surrounding the developing oocyte, with tight quantitative control and a very narrow temporal specificity [10].

Other interactions of Cp15


  1. E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein. Handa, K., Yugawa, T., Narisawa-Saito, M., Ohno, S., Fujita, M., Kiyono, T. J. Virol. (2007) [Pubmed]
  2. Proteins that bind to Drosophila chorion cis-regulatory elements: a new C2H2 zinc finger protein and a C2C2 steroid receptor-like component. Shea, M.J., King, D.L., Conboy, M.J., Mariani, B.D., Kafatos, F.C. Genes Dev. (1990) [Pubmed]
  3. Multiple replication origins are used during Drosophila chorion gene amplification. Heck, M.M., Spradling, A.C. J. Cell Biol. (1990) [Pubmed]
  4. Both early and late Drosophila chorion gene promoters confer correct temporal, tissue and sex specificity on a reporter Adh gene. Romano, C.P., Bienz-Tadmor, B., Mariani, B.D., Kafatos, F.C. EMBO J. (1988) [Pubmed]
  5. DNA binding and heteromerization of the Drosophila transcription factor chorion factor 1/ultraspiracle. Christianson, A.M., King, D.L., Hatzivassiliou, E., Casas, J.E., Hallenbeck, P.L., Nikodem, V.M., Mitsialis, S.A., Kafatos, F.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. Purification of Drosophila melanogaster ultraspiracle protein and analysis of its A/B region-dependent dimerization behavior in vitro. Rymarczyk, G., Grad, I., Rusek, A., Oświecimska-Rusin, K., Niedziela-Majka, A., Kochman, M., Ozyhar, A. Biol. Chem. (2003) [Pubmed]
  7. Evolution of the autosomal chorion locus in Drosophila. I. General organization of the locus and sequence comparisons of genes s15 and s19 in evolutionary distant species. Martínez-Cruzado, J.C., Swimmer, C., Fenerjian, M.G., Kafatos, F.C. Genetics (1988) [Pubmed]
  8. The chorion genes of the medfly. II. DNA sequence evolution of the autosomal chorion genes s18, s15, s19 and s16 in Diptera. Vlachou, D., Komitopoulou, K. Gene (2001) [Pubmed]
  9. Coding and potential regulatory sequences of a cluster of chorion genes in Drosophila melanogaster. Wong, Y.C., Pustell, J., Spoerel, N., Kafatos, F.C. Chromosoma (1985) [Pubmed]
  10. Analysis of regulatory elements of the developmentally controlled chorion s15 promoter in transgenic Drosophila. Mariani, B.D., Shea, M.J., Conboy, M.J., Conboy, I., King, D.L., Kafatos, F.C. Dev. Biol. (1996) [Pubmed]
  11. Binding affinity of the Drosophila melanogaster CF1/USP protein to the chorion s15 promoter. Christianson, A.M., Kafatos, F.C. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  12. Developmentally regulated expression of Drosophila chorion genes introduced at diverse chromosomal positions. Wakimoto, B.T., Kalfayan, L.J., Spradling, A.C. J. Mol. Biol. (1986) [Pubmed]
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