High impact information on sesB

• Adenine nucleotide translocase (ANT) was found to be the only protein in the mitochondrial membranes exhibiting a detectable age-associated increase in carbonyls [1].
• A temperature-sensitive allele of Drosophila sesB reveals acute functions for the mitochondrial adenine nucleotide translocase in synaptic transmission and dynamin regulation [2].
• When both rescuing genes are present, Hmr in the father and mhr in the mother, males of this genotype are fully viable, as predicted [3].
• Letting C, X, and Y designate egg cytoplasm, X, and Y chromosomes, respectively, and subscripts m and s stand for melanogaster and simulans, CmXmYs males are lethal in the larval stage and are rescued by the previously reported genes, Lhr (Lethal hybrid rescue) in simulans or Hmr (Hybrid male rescue) in melanogaster [3].
• We therefore postulate that both stress-sensitive mutants harbor unique neurotransmission defects: Atpalpha(2206) mutants are unable to maintain ionic gradients required during repetitive action potential propagation, and sesB mutants cannot maintain synaptic vesicle cycling during periods of high demand [4].

Biological context of sesB

• The X-linked gene Hmr in Drosophila melanogaster, when mutated, rescues otherwise inviable interspecific hybrids from crosses between D. melanogaster and any of its three most closely related species D. simulans, D. mauritiana and D. sechellia [5].

Anatomical context of sesB

• The basal proton conductance of mitochondria depends on adenine nucleotide translocase content [6].
• We show that the proton conductance of muscle mitochondria from mice in which isoform 1 of the adenine nucleotide translocase has been ablated is half that of wild-type controls [6].
• Using the neuromuscular junction (NMJ), this study investigates synaptic function more specifically in two stress-sensitive mutants: stress-sensitive B (sesB), which encodes a mitochondrial ADP/ATP translocase (ANT); and Atpalpha(2206), a conditional mutant of the Na+/K+ ATPase alpha-subunit [4].

Analytical, diagnostic and therapeutic context of sesB

• We studied such correlation in Drosophila melanogaster in caloric restriction and in mutant flies overexpressing the mitochondrial adenine nucleotide translocase (ANT) [7].

References