Disease relevance of SLC25A4

• Primary biliary cirrhosis: assessment of the quantitative importance of the adenine nucleotide translocator protein as a major mitochondrial antigen [1].
• The frequency, dynamical change and effects of autoantibodies against the adenine nucleotide translocator (ANT) in idiopathic dilated cardiomyopathy (IDC) were studied [2].

High impact information on SLC25A4

• Additionally, palmitic acid but not palmitoleic acid decreased the expression of the mitochondrial adenine nucleotide translocator and induced release of cytochrome c from the mitochondria into the cytosol [3].
• Differential expression of adenine nucleotide translocator isoforms in mammalian tissues and during muscle cell differentiation [4].
• ANT1 is highly expressed in heart and skeletal muscle and is induced during myoblast differentiation [4].
• The ADP,ATP carrier-linked binding protein of beef heart mitochondria was isolated free of ligands, using the detergent 3-lauramido-N,N-dimethylpropylamine oxide [5].
• The reorientation model of Klingenberg for the ADP,ATP carrier implicating an ADP-catalyzed transition between the CAT binding form (c state) and BKA binding form (m state) in the inner mitochondrial membrane has been confirmed in this reconstituted system [6].

Biological context of SLC25A4

• Immunochemical characterization of the adenine nucleotide translocator. Organ specificity and conformation specificity [7].
• Amino acid sequence determination of the ADP,ATP carrier from beef heart mitochondria. The sequence of the C-terminal acidolytic fragment [8].

Anatomical context of SLC25A4

• Characterization of pyrophosphate exchange by the reconstituted adenine nucleotide translocator from mitochondria [9].

Associations of SLC25A4 with chemical compounds

• The transport of inorganic pyrophosphate (PPi) by the adenine nucleotide translocator from beef heart mitochondria was studied in a reconstituted system [9].
• The adenine nucleotide translocator is a hydrophobic, basic protein of the inner mitochondrial membrane which is solubilized by the non-ionic detergent Triton X-100 [10].
• We have used a peptide trivalent arsenical, 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO), to inactivate the adenine nucleotide translocator (ANT) that exchanges matrix ATP for cytosolic ADP across the inner mitochondrial membrane and is the key component of the mitochondrial permeability transition pore (MPTP) [11].

Analytical, diagnostic and therapeutic context of SLC25A4

• Fine mapping of the bovine solute carrier family 25, member 4 (SLC25A4) gene to BTA27q14-q15 by fluorescence in situ hybridization and radiation hybrid mapping [12].
• The contribution of the adenine nucleotide translocator to this dependence was determined by titration with the irreversible inhibitor carboxyatractyloside in the presence of ADP [13].

References