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Gene Review

Slc25a4  -  solute carrier family 25 (mitochondrial...

Mus musculus

Synonyms: ADP,ATP carrier protein 1, ADP,ATP carrier protein, heart/skeletal muscle isoform T1, ADP/ATP translocase 1, ANT 1, AU019225, ...
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Disease relevance of Slc25a4


High impact information on Slc25a4


Biological context of Slc25a4


Anatomical context of Slc25a4


Associations of Slc25a4 with chemical compounds

  • The influence of chromatin on the human adenine nucleotide translocase isoform 2 (ANT2) promoter was investigated in transfected cells treated with the deacetylase inhibitors butyrate and trichostatin A (TSA) [14].
  • Thus, the astrocytic response to CNS injury includes an apparent increase in energy mobilization capacity by Ant1 that contributes to neuroprotective, energy-dependent glutamate uptake [12].
  • The amounts of ATP attained with glutamine were decreased in some instances by the addition of atractyloside, an inhibitor of adenine nucleotide translocase in mitochondria, and were decreased consistently and to a greater extent by 2,4-dinitrophenol [15].
  • The synthetic tripeptide arsenical 4-(N-(S-glutathionylacetyl)amino)p-phenylarsenoxide (p-GSAO) is an angiogenesis inhibitor that inactivates mitochondrial adenine nucleotide translocase (ANT) by cross-linking a pair of matrix-facing cysteine residues [16].
  • All these findings indicate that mitochondrial creatine kinase activity located within the intermembrane and intercristae space, in conjunction with its tight functional coupling to oxidative phosphorylation, via the adenine nucleotide translocase, can modulate mitochondrial permeability transition in the presence of creatine [17].

Regulatory relationships of Slc25a4


Other interactions of Slc25a4

  • Repeats constituted 32% of 15kb of Ant1 sequence and 36% of the 27kb of Ant2 sequence and included SINEs, LINEs and LTR elements [7].
  • A 69 basepair TGF-beta1 responsive element of the Ant1 promoter was also identified [10].
  • The Ant1 gene maps near Klk3 on proximal mouse chromosome 8 [18].
  • Consistent with the lower antioxidant defenses in heart, the heart mtDNAs of the Ant1-deficient mice showed a striking increase in the accumulation of mtDNA rearrangements, whereas skeletal muscle, with higher antioxidant defenses, had fewer mtDNA rearrangements [11].
  • Con sequently, superoxide was generated at a higher rate, and several mitochondrial proteins, including adenine nucleotide translocase 1 (ANT1), were more oxidized by HSF1 deficiency in vivo [19].

Analytical, diagnostic and therapeutic context of Slc25a4


  1. A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Graham, B.H., Waymire, K.G., Cottrell, B., Trounce, I.A., MacGregor, G.R., Wallace, D.C. Nat. Genet. (1997) [Pubmed]
  2. Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Vander Heiden, M.G., Chandel, N.S., Schumacker, P.T., Thompson, C.B. Mol. Cell (1999) [Pubmed]
  3. The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins. Marzo, I., Brenner, C., Zamzami, N., Susin, S.A., Beutner, G., Brdiczka, D., Rémy, R., Xie, Z.H., Reed, J.C., Kroemer, G. J. Exp. Med. (1998) [Pubmed]
  4. Mitochondrial control of nuclear apoptosis. Zamzami, N., Susin, S.A., Marchetti, P., Hirsch, T., Gómez-Monterrey, I., Castedo, M., Kroemer, G. J. Exp. Med. (1996) [Pubmed]
  5. Mitochondrial permeability transition is a central coordinating event of apoptosis. Marchetti, P., Castedo, M., Susin, S.A., Zamzami, N., Hirsch, T., Macho, A., Haeffner, A., Hirsch, F., Geuskens, M., Kroemer, G. J. Exp. Med. (1996) [Pubmed]
  6. Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor. Weaver, J.G., Tarze, A., Moffat, T.C., Lebras, M., Deniaud, A., Brenner, C., Bren, G.D., Morin, M.Y., Phenix, B.N., Dong, L., Jiang, S.X., Sim, V.L., Zurakowski, B., Lallier, J., Hardin, H., Wettstein, P., van Heeswijk, R.P., Douen, A., Kroemer, R.T., Hou, S.T., Bennett, S.A., Lynch, D.H., Kroemer, G., Badley, A.D. J. Clin. Invest. (2005) [Pubmed]
  7. Expression and sequence analysis of the mouse adenine nucleotide translocase 1 and 2 genes. Levy, S.E., Chen, Y.S., Graham, B.H., Wallace, D.C. Gene (2000) [Pubmed]
  8. Rapid evolution of human pseudoautosomal genes and their mouse homologs. Ellison, J.W., Li, X., Francke, U., Shapiro, L.J. Mamm. Genome (1996) [Pubmed]
  9. Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis. Bauer, M.K., Schubert, A., Rocks, O., Grimm, S. J. Cell Biol. (1999) [Pubmed]
  10. TGF-beta1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors. Law, A.K., Gupta, D., Levy, S., Wallace, D.C., McKeon, R.J., Buck, C.R. BMC neuroscience [electronic resource]. (2004) [Pubmed]
  11. Mitochondrial disease in mouse results in increased oxidative stress. Esposito, L.A., Melov, S., Panov, A., Cottrell, B.A., Wallace, D.C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  12. Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport. Buck, C.R., Jurynec, M.J., Gupta, D.K., Law, A.K., Bilger, J., Wallace, D.C., McKeon, R.J. Exp. Neurol. (2003) [Pubmed]
  13. Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent pathways. Jang, J.Y., Lee, C.E. Cell. Immunol. (2003) [Pubmed]
  14. Sp1 and chromatin environment are important contributors to the formation of repressive chromatin structures on the transfected human adenine nucleotide translocase-2 promoter. Hodny, Z., Li, R., Barath, P., Nelson, B.D. Biochem. J. (2000) [Pubmed]
  15. Energy metabolism of monocytic Ehrlichia. Weiss, E., Williams, J.C., Dasch, G.A., Kang, Y.H. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  16. Para to ortho repositioning of the arsenical moiety of the angiogenesis inhibitor 4-(N-(S-glutathionylacetyl)amino)phenylarsenoxide results in a markedly increased cellular accumulation and antiproliferative activity. Dilda, P.J., Decollogne, S., Rossiter-Thornton, M., Hogg, P.J. Cancer Res. (2005) [Pubmed]
  17. Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation. Dolder, M., Walzel, B., Speer, O., Schlattner, U., Wallimann, T. J. Biol. Chem. (2003) [Pubmed]
  18. The Ant1 gene maps near Klk3 on proximal mouse chromosome 8. Mills, K.A., Ellison, J.W., Mathews, K.D. Mamm. Genome (1996) [Pubmed]
  19. Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. Yan, L.J., Christians, E.S., Liu, L., Xiao, X., Sohal, R.S., Benjamin, I.J. EMBO J. (2002) [Pubmed]
  20. Induction of multiple heart autoantibodies in mice with coxsackievirus B3- and cardiac myosin-induced autoimmune myocarditis. Neumann, D.A., Rose, N.R., Ansari, A.A., Herskowitz, A. J. Immunol. (1994) [Pubmed]
  21. Development and characterization of ten monoclonal anti-Vpr antibodies. Sabbah, E.N., Delaunay, T., Varin, A., Le-Rouzic, E., Benichou, S., Herbein, G., Druillennec, S., Roques, B.P. AIDS Res. Hum. Retroviruses (2006) [Pubmed]
  22. Autoimmunity in myocarditis: relevance of animal models. Huber, S.A. Clin. Immunol. Immunopathol. (1997) [Pubmed]
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