High impact information on Cadps2

• The structure of CAPS2 and its function in LDCV exocytosis from PC12 cells are very similar to those of CAPS1 [1].
• On the other hand, CAPS2 was localized to distinct cell types and fibers of various brain regions, including the olfactory bulb, cerebrum, hippocampal formation, thalamus, mesencephalic tegmentum, cerebellum, medulla, and spinal cord, except for some regions that overlapped with CAPS1 [2].
• These results demonstrate that the CAPS family proteins are involved in the secretion of different secretory substances in developing and postnatal brains, and that CAPS2 is probably involved in BDNF secretion in many brain areas [2].
• By fluorescent differential display, we identified six transcripts (CAPS2/Cadps2, Cdh22, b1402, c1502, d1401, and d1501) that showed the differential expression patterns during the postnatal development of the mouse cerebellum [3].
• Moreover, the overexpression of CAPS2 in granule cells promotes the survival of Purkinje cells in cerebellar cultures [4].

Biological context of Cadps2

• The Ca(2+)-dependent activator protein for secretion (CAPS/Cadps) family consists of two members, CAPS1 and CAPS2, and plays an important role in secretory granule exocytosis [2].
• The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival [4].

Anatomical context of Cadps2

• CAPS2 is enriched on vesicular structures of presynaptic parallel fiber terminals of granule cells connecting postsynaptic spines of Purkinje cell dendrites [4].

Other interactions of Cadps2

• In most areas of the embryonic nervous system CAPS1 and CAPS2 proteins were complementarily expressed [2].

References