Disease relevance of prdm1

• This is in contrast to other sensory systems, such as the neurons of the lateral line ganglion, where nrd is regulated by ngn1 and not by ath1 [1].

High impact information on prdm1

• The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling [2].
• Expression of ubo is induced by Hedgehog (Hh) signaling in prospective slow muscle precursors, and its activity alone is sufficient to direct slow-twitch fiber-specific development by naive myoblasts [2].
• Fgf signaling is required for prdm1 expression in the fin bud, but is not necessary for the initiation of tbx5 expression [3].
• Misexpression of prdm1 inhibits the formation of dorsoanterior structures and reduces expression of chordin, which encodes a BMP antagonist [4].
• At the end of the gastrula period, prdm1 morphant embryos have enlarged animal-vegetal and anteroposterior embryonic axes [4].

Biological context of prdm1

• Essential roles of a zebrafish prdm1/blimp1 homolog in embryo patterning and organogenesis [4].
• Here, we show that nrd is a mutation in prdm1, a SET/zinc-finger domain transcription factor [5].
• A Morpholino-mediated depletion of prdm1 phenocopies the nrd mutation, and conversely overexpression of prdm1 mRNA rescues the nrd RB sensory neuron and neural crest phenotype. prdm1 is expressed at the border of the neural plate within the domain where neural crest cells and RB sensory neurons form [5].

Anatomical context of prdm1

• Zebrafish narrowminded disrupts the transcription factor prdm1 and is required for neural crest and sensory neuron specification [5].
• Here, we show that the zebrafish homolog of the B-lymphocyte-induced maturation protein (Blimp-1) gene, u-boot (ubo), is induced by BMP signaling in cells at the boundary of the neural plate and nonneural ectoderm [6].
• We show that, in the zebrafish, two proneural genes are essential for differentiation of the hair cells, neuroD (nrd) and atonal homolog 1 (ath1) [1].

References