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Gene Review

PRDM1  -  PR domain containing 1, with ZNF domain

Homo sapiens

Synonyms: BLIMP-1, BLIMP1, Beta-interferon gene positive regulatory domain I-binding factor, PR domain zinc finger protein 1, PR domain-containing protein 1, ...
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Disease relevance of PRDM1

  • Unexpectedly, a subset of diffuse large B-cell lymphoma expressed PRDM1, lacked detectable plasmablastic or immunoblastic changes and displayed more aggressive behavior, with a shorter failure-free survival [1].
  • Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma [2].
  • Here we show PRDI-BF1 assembles silent chromatin over the interferon-beta promoter in the osteosarcoma cell line U2OS through recruitment of the histone H3 lysine methyltransferase G9a [3].
  • We report here that the BLIMP1 gene is inactivated by structural alterations in 24% (8 out of 34) activated B cell-like diffuse large cell lymphoma (ABC-DLBCL), but not in GC B cell-like (n = 0/37) or unclassified (n = 0/21) DLBCL [4].
  • Since Pax-5 and Id-2 transcription factors play an opposing role in AID regulation, we have studied the expression of Pax-5, Id-2, and prdm-1 genes in 54 chronic lymphocytic leukemia (CLL) B cells [5].

High impact information on PRDM1


Biological context of PRDM1


Anatomical context of PRDM1


Physical interactions of PRDM1

  • We hypothesize that premature Blimp-1 expression coupled to altered and deficient Pax5 expression causes some proliferating B cells to prematurely differentiate to plasma cells in MM [2].
  • The results show that Blimp-1 represses the c-myc promoter by an active mechanism that is independent of the adjacently bound activator YY1 [15].
  • Repression of CIITA depends on the DNA binding activity of PRDI-BF1 and its specific binding site in the CIITA promoter [16].

Regulatory relationships of PRDM1


Other interactions of PRDM1


Analytical, diagnostic and therapeutic context of PRDM1


  1. PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma. Garcia, J.F., Roncador, G., García, J.F., Sánz, A.I., Maestre, L., Lucas, E., Montes-Moreno, S., Victoria, R.F., Martinez-Torrecuadrara, J.L., Marafioti, T., Mason, D.Y., Piris, M.A. Haematologica (2006) [Pubmed]
  2. Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma. Borson, N.D., Lacy, M.Q., Wettstein, P.J. Blood (2002) [Pubmed]
  3. PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. Gyory, I., Wu, J., Fejér, G., Seto, E., Wright, K.L. Nat. Immunol. (2004) [Pubmed]
  4. Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. Pasqualucci, L., Compagno, M., Houldsworth, J., Monti, S., Grunn, A., Nandula, S.V., Aster, J.C., Murty, V.V., Shipp, M.A., Dalla-Favera, R. J. Exp. Med. (2006) [Pubmed]
  5. Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells. Oppezzo, P., Dumas, G., Lalanne, A.I., Payelle-Brogard, B., Magnac, C., Pritsch, O., Dighiero, G., Vuillier, F. Blood (2005) [Pubmed]
  6. PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Ren, B., Chee, K.J., Kim, T.H., Maniatis, T. Genes Dev. (1999) [Pubmed]
  7. Identification and characterization of a novel repressor of beta-interferon gene expression. Keller, A.D., Maniatis, T. Genes Dev. (1991) [Pubmed]
  8. STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression. Scheeren, F.A., Naspetti, M., Diehl, S., Schotte, R., Nagasawa, M., Wijnands, E., Gimeno, R., Vyth-Dreese, F.A., Blom, B., Spits, H. Nat. Immunol. (2005) [Pubmed]
  9. Expression of PAX5 in CD20-positive multiple myeloma assessed by immunohistochemistry and oligonucleotide microarray. Lin, P., Mahdavy, M., Zhan, F., Zhang, H.Z., Katz, R.L., Shaughnessy, J.D. Mod. Pathol. (2004) [Pubmed]
  10. Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins. Gupta, S., Anthony, A., Pernis, A.B. J. Immunol. (2001) [Pubmed]
  11. The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10. Mock, B.A., Liu, L., LePaslier, D., Huang, S. Genomics (1996) [Pubmed]
  12. Repression of IFN-{gamma} Induction of Class II Transactivator: A Role for PRDM1/Blimp-1 in Regulation of Cytokine Signaling. Tooze, R.M., Stephenson, S., Doody, G.M. J. Immunol. (2006) [Pubmed]
  13. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Sciammas, R., Shaffer, A.L., Schatz, J.H., Zhao, H., Staudt, L.M., Singh, H. Immunity (2006) [Pubmed]
  14. Transcription factors that regulate memory in humoral responses. Calame, K. Immunol. Rev. (2006) [Pubmed]
  15. Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. Yu, J., Angelin-Duclos, C., Greenwood, J., Liao, J., Calame, K. Mol. Cell. Biol. (2000) [Pubmed]
  16. Positive regulatory domain I binding factor 1 silences class II transactivator expression in multiple myeloma cells. Ghosh, N., Gyory, I., Wright, G., Wood, J., Wright, K.L. J. Biol. Chem. (2001) [Pubmed]
  17. Survival and proliferation factors of normal and malignant plasma cells. Klein, B., Tarte, K., Jourdan, M., Mathouk, K., Moreaux, J., Jourdan, E., Legouffe, E., De Vos, J., Rossi, J.F. Int. J. Hematol. (2003) [Pubmed]
  18. Cytokine-Dependent Blimp-1 Expression in Activated T Cells Inhibits IL-2 Production. Gong, D., Malek, T.R. J. Immunol. (2007) [Pubmed]
  19. Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development. Messika, E.J., Lu, P.S., Sung, Y.J., Yao, T., Chi, J.T., Chien, Y.H., Davis, M.M. J. Exp. Med. (1998) [Pubmed]
  20. Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. Györy, I., Fejér, G., Ghosh, N., Seto, E., Wright, K.L. J. Immunol. (2003) [Pubmed]
  21. The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein. Buyse, I.M., Shao, G., Huang, S. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  22. Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage. Avery, D.T., Ellyard, J.I., Mackay, F., Corcoran, L.M., Hodgkin, P.D., Tangye, S.G. J. Immunol. (2005) [Pubmed]
  23. Selection of sequences recognized by a DNA binding protein using a preparative southwestern blot. Keller, A.D., Maniatis, T. Nucleic Acids Res. (1991) [Pubmed]
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