High impact information on Hrs

• Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila [1].
• Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction [2].
• Conversely, the expression of Wg targets is enhanced by increased transport to endosomes or decreased hepatocyte growth factor-regulated tyrosine kinase substrate- mediated transport from endosomes [3].
• Instead, we show that Su(dx) regulates the postendocytic sorting of Notch within the early endosome to an Hrs- and ubiquitin-enriched subdomain en route to the late endosome [4].
• Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs [5].

Biological context of Hrs

• Hrs mediates downregulation of multiple signalling receptors in Drosophila [6].
• Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs [7].

Anatomical context of Hrs

• Subsequently, Wg, Arrow and DFz2 are trafficked through the endocytic pathway to the lysosome, where they are degraded in a hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs)-dependent manner [8].

Other interactions of Hrs

• These enlarged endosomes are positive for Rab5 and Hrs, a protein involved in trafficking into the degradative pathway [7].
• Instead, loss of Hrs increases Dpp signalling and the level of the type-I receptor Thickveins (Tkv) [6].
• Hrs/Vps27p, an endosome-associated, ubiquitin-binding protein, affects sorting and degradation of receptors [6].

References