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Gene Review

Hrs  -  Hepatocyte growth factor regulated...

Drosophila melanogaster

Synonyms: CG2903, DmHRS, Dmel\CG2903, HRS, HRS-2, ...
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High impact information on Hrs


Biological context of Hrs

  • Hrs mediates downregulation of multiple signalling receptors in Drosophila [6].
  • Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs [7].

Anatomical context of Hrs


Other interactions of Hrs

  • These enlarged endosomes are positive for Rab5 and Hrs, a protein involved in trafficking into the degradative pathway [7].
  • Instead, loss of Hrs increases Dpp signalling and the level of the type-I receptor Thickveins (Tkv) [6].
  • Hrs/Vps27p, an endosome-associated, ubiquitin-binding protein, affects sorting and degradation of receptors [6].


  1. Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Lloyd, T.E., Atkinson, R., Wu, M.N., Zhou, Y., Pennetta, G., Bellen, H.J. Cell (2002) [Pubmed]
  2. Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. Mao, Y., Nickitenko, A., Duan, X., Lloyd, T.E., Wu, M.N., Bellen, H., Quiocho, F.A. Cell (2000) [Pubmed]
  3. Internalization is required for proper Wingless signaling in Drosophila melanogaster. Seto, E.S., Bellen, H.J. J. Cell Biol. (2006) [Pubmed]
  4. Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins. Wilkin, M.B., Carbery, A.M., Fostier, M., Aslam, H., Mazaleyrat, S.L., Higgs, J., Myat, A., Evans, D.A., Cornell, M., Baron, M. Curr. Biol. (2004) [Pubmed]
  5. Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs. Stahelin, R.V., Long, F., Diraviyam, K., Bruzik, K.S., Murray, D., Cho, W. J. Biol. Chem. (2002) [Pubmed]
  6. Hrs mediates downregulation of multiple signalling receptors in Drosophila. Jékely, G., Rørth, P. EMBO Rep. (2003) [Pubmed]
  7. The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila. Gallagher, C.M., Knoblich, J.A. Dev. Cell (2006) [Pubmed]
  8. Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing. Rives, A.F., Rochlin, K.M., Wehrli, M., Schwartz, S.L., Dinardo, S. Dev. Biol. (2006) [Pubmed]
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