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Gene Review

Hgs  -  hepatocyte growth factor-regulated...

Rattus norvegicus

Synonyms: Hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, Hrs2, SNAP-25-interacting protein Hrs-2
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High impact information on Hgs

  • Moreover, recombinant Hrs-2 inhibits calcium-triggered 3H-noradrenaline release from permeabilized PC12 cells [1].
  • Furthermore, Hrs-2 binds and hydrolyses nucleoside triphosphates with kinetics that suggest that ATP is the physiological substrate for this enzyme [1].
  • The binding of Hrs-2 to SNAP-25 is inhibited by calcium in the physiological concentration range that supports synaptic transmission [1].
  • Hrs-2, via interactions with SNAP-25, plays a regulatory role on the exocytic machinery [2].
  • We now show that Hrs-2 physically interacts with Eps15, a protein required for receptor-mediated endocytosis [2].

Biological context of Hgs


Anatomical context of Hgs


Associations of Hgs with chemical compounds


Other interactions of Hgs

  • Large varicosities containing VAMP-2- and Hrs-2 immunocreactivity were seen in salt-loaded animals [9].
  • The presence of Hrs-2 protein in rat kidney was confirmed by immunoblotting, revealing a 115-kDa protein in kidney and brain membrane fractions corresponding to the expected molecular size of Hrs-2 [5].
  • Immunostaining and confocal laser scanning microscopy of LLC-PK(1) cells (a porcine proximal tubule cell line) transfected with Hrs-2 DNA confirmed the specificity of the antibody and revealed that Hrs-2 is mainly localized in intracellular compartments, including cathepsin D-containing lysosomal/endosomal compartments [5].

Analytical, diagnostic and therapeutic context of Hgs


  1. Hrs-2 is an ATPase implicated in calcium-regulated secretion. Bean, A.J., Seifert, R., Chen, Y.A., Sacks, R., Scheller, R.H. Nature (1997) [Pubmed]
  2. Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15. Bean, A.J., Davanger, S., Chou, M.F., Gerhardt, B., Tsujimoto, S., Chang, Y. J. Biol. Chem. (2000) [Pubmed]
  3. Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis. Kwong, J., Roundabush, F.L., Hutton Moore, P., Montague, M., Oldham, W., Li, Y., Chin, L.S., Li, L. J. Cell. Sci. (2000) [Pubmed]
  4. Molecular cloning of a rat brain cDNA, with homology to a tyrosine kinase substrate, that induces galactosylceramide expression in COS-7 cells. Ogura, K., Kohno, K., Tai, T. J. Neurochem. (1998) [Pubmed]
  5. SNAP-25-associated Hrs-2 protein colocalizes with AQP2 in rat kidney collecting duct principal cells. Shukla, A., Hager, H., Corydon, T.J., Bean, A.J., Dahl, R., Vajda, Z., Li, H., Hoffmann, H.J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  6. HRS inhibits EGF receptor signaling in the RT4 rat schwannoma cell line. Scoles, D.R., Qin, Y., Nguyen, V., Gutmann, D.H., Pulst, S.M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  7. Estrogen down-regulates mRNA encoding the exocytotic protein SNAP-25 in the rat pituitary gland. Jacobsson, G., Razani, H., Ogren, S.O., Meister, B. J. Neuroendocrinol. (1998) [Pubmed]
  8. Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1. Huang, S.H., Zhao, L., Sun, Z.P., Li, X.Z., Geng, Z., Zhang, K.D., Chao, M.V., Chen, Z.Y. J. Biol. Chem. (2009) [Pubmed]
  9. Isoform-specific exocytotic protein mRNA expression in hypothalamic magnocellular neurons: regulation after osmotic challenge. Jacobsson, G., Bean, A.J., Meister, B. Neuroendocrinology (1999) [Pubmed]
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