Gene Review:
fz2 - frizzled 2
Drosophila melanogaster
Synonyms:
CG9739, D-Fz2, D-fz2, DFZ2, DFz-2, ...
- Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Slusarski, D.C., Corces, V.G., Moon, R.T. Nature (1997)
- frizzled and frizzled 2 play a partially redundant role in wingless signaling and have similar requirements to wingless in neurogenesis. Bhat, K.M. Cell (1998)
- Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing. Cadigan, K.M., Fish, M.P., Rulifson, E.J., Nusse, R. Cell (1998)
- Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Boutros, M., Paricio, N., Strutt, D.I., Mlodzik, M. Cell (1998)
- Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP. Ataman, B., Ashley, J., Gorczyca, D., Gorczyca, M., Mathew, D., Wichmann, C., Sigrist, S.J., Budnik, V. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Genome-wide identification of in vivo Drosophila Engrailed-binding DNA fragments and related target genes. Solano, P.J., Mugat, B., Martin, D., Girard, F., Huibant, J.M., Ferraz, C., Jacq, B., Demaille, J., Maschat, F. Development (2003)
- Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction. Moline, M.M., Dierick, H.A., Southern, C., Bejsovec, A. Curr. Biol. (2000)
- Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development. Bhanot, P., Fish, M., Jemison, J.A., Nusse, R., Nathans, J., Cadigan, K.M. Development (1999)
- Overexpression of components of the Frizzled-Dishevelled cascade results in apoptotic cell death, mediated by beta-catenin. van Gijn, M.E., Snel, F., Cleutjens, J.P., Smits, J.F., Blankesteijn, W.M. Exp. Cell Res. (2001)
- Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues. Chan, S.D., Karpf, D.B., Fowlkes, M.E., Hooks, M., Bradley, M.S., Vuong, V., Bambino, T., Liu, M.Y., Arnaud, C.D., Strewler, G.J. J. Biol. Chem. (1992)
- Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing. Rives, A.F., Rochlin, K.M., Wehrli, M., Schwartz, S.L., Dinardo, S. Dev. Biol. (2006)
- Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. Mathew, D., Ataman, B., Chen, J., Zhang, Y., Cumberledge, S., Budnik, V. Science (2005)
- Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. Schweizer, L., Varmus, H. BMC Cell Biol. (2003)
- Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling. Lin, X., Perrimon, N. Nature (1999)
- Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants. Sato, A., Kojima, T., Ui-Tei, K., Miyata, Y., Saigo, K. Development (1999)
- DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. Cohen, E.D., Mariol, M.C., Wallace, R.M., Weyers, J., Kamberov, Y.G., Pradel, J., Wilder, E.L. Dev. Cell (2002)