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Gene Review:

LOC337917 - interferon regulatory factor 1

Bos taurus

Faure, V. et al., Suter, J. et al., Faure, V. et al., Kiermer, V. et al.

Kiermer, Van Lint, Briclet, Vanhulle, Kettmann, Verdin, Burny, Droogmans,

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Disease relevance of IRF1

An interferon regulatory factor binding site in the U5 region of the bovine leukemia virus long terminal repeat stimulates Tax-independent gene expression [1].

High impact information on IRF1

Analysis by reverse transcriptase-polymerase chain reaction, Western blot, and electrophoretic mobility shift assay demonstrated that IFN-gamma alone or combined with LPS induced an accumulation of IRF-1 mRNA and protein and IRF-1 DNA binding [2].
Transfections assays with the IRF-1 promoter showed an induction of this promoter with IFN-gamma, potentiated by LPS [2].
Role of interferon regulatory factor-1 and mitogen-activated protein kinase pathways in the induction of nitric oxide synthase-2 in retinal pigmented epithelial cells [2].
This phenomenon could be due to the decline of IRF-1 mRNA and the up-regulation of IRF-2 mRNA, an IRF-1 repressor, by IFN-alpha [3].
These data suggest that IFNgamma treatment can activate members of the STAT pathway, resulting in increased levels of IRF-1 [4].

Associations of IRF1 with chemical compounds

Our results demonstrate that IRF-1 is necessary for NOS-2 induction by LPS and IFN-gamma and that its synthesis requires the involvement of a redox-sensitive step, the activation of tyrosine kinases, and extracellular signal-regulated kinases 1/2 and p38 MAP kinases [2].

Other interactions of IRF1

However, similar experiments revealed that the activation of interferon regulatory factor-1 (IRF-1) by LPS/IFN-gamma was decreased by IFN-alpha [3].
The present experiment demonstrates that the steroidogenic cells of the corpus luteum have the capacity to respond to IFNgamma via activation of STAT and IRF-1, providing further evidence that IFNgamma may be involved in the luteolytic process [4].

Analytical, diagnostic and therapeutic context of IRF1

Fractionated or total cell lysates were evaluated by the Western blotting technique to determine the changes in the levels of signal transducers and activators of transcription (STAT), interferon regulatory factor 1 (IRF-1), and I kappa B alpha (IkappaB-alpha) [4].

References

An interferon regulatory factor binding site in the U5 region of the bovine leukemia virus long terminal repeat stimulates Tax-independent gene expression. Kiermer, V., Van Lint, C., Briclet, D., Vanhulle, C., Kettmann, R., Verdin, E., Burny, A., Droogmans, L. J. Virol. (1998) [Pubmed]
Role of interferon regulatory factor-1 and mitogen-activated protein kinase pathways in the induction of nitric oxide synthase-2 in retinal pigmented epithelial cells. Faure, V., Hecquet, C., Courtois, Y., Goureau, O. J. Biol. Chem. (1999) [Pubmed]
Inhibition of inducible nitric oxide synthase expression by interferons alpha and beta in bovine retinal pigmented epithelial cells. Faure, V., Courtois, Y., Goureau, O. J. Biol. Chem. (1997) [Pubmed]
Mediators of interferon gamma-initiated signaling in bovine luteal cells. Suter, J., Hendry, I.R., Ndjountche, L., Obholz, K., Pru, J.K., Davis, J.S., Rueda, B.R. Biol. Reprod. (2001) [Pubmed]

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