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Gene Review

LOC337917  -  interferon regulatory factor 1

Bos taurus

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Disease relevance of IRF1


High impact information on IRF1


Associations of IRF1 with chemical compounds

  • Our results demonstrate that IRF-1 is necessary for NOS-2 induction by LPS and IFN-gamma and that its synthesis requires the involvement of a redox-sensitive step, the activation of tyrosine kinases, and extracellular signal-regulated kinases 1/2 and p38 MAP kinases [2].

Other interactions of IRF1

  • However, similar experiments revealed that the activation of interferon regulatory factor-1 (IRF-1) by LPS/IFN-gamma was decreased by IFN-alpha [3].
  • The present experiment demonstrates that the steroidogenic cells of the corpus luteum have the capacity to respond to IFNgamma via activation of STAT and IRF-1, providing further evidence that IFNgamma may be involved in the luteolytic process [4].

Analytical, diagnostic and therapeutic context of IRF1


  1. An interferon regulatory factor binding site in the U5 region of the bovine leukemia virus long terminal repeat stimulates Tax-independent gene expression. Kiermer, V., Van Lint, C., Briclet, D., Vanhulle, C., Kettmann, R., Verdin, E., Burny, A., Droogmans, L. J. Virol. (1998) [Pubmed]
  2. Role of interferon regulatory factor-1 and mitogen-activated protein kinase pathways in the induction of nitric oxide synthase-2 in retinal pigmented epithelial cells. Faure, V., Hecquet, C., Courtois, Y., Goureau, O. J. Biol. Chem. (1999) [Pubmed]
  3. Inhibition of inducible nitric oxide synthase expression by interferons alpha and beta in bovine retinal pigmented epithelial cells. Faure, V., Courtois, Y., Goureau, O. J. Biol. Chem. (1997) [Pubmed]
  4. Mediators of interferon gamma-initiated signaling in bovine luteal cells. Suter, J., Hendry, I.R., Ndjountche, L., Obholz, K., Pru, J.K., Davis, J.S., Rueda, B.R. Biol. Reprod. (2001) [Pubmed]
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