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Gene Review

Mnn1  -  Menin 1

Drosophila melanogaster

Synonyms: CG13778, CG33266, Dmel\CG13778, MEN1, Menin1, ...
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Disease relevance of Mnn1


High impact information on Mnn1


Biological context of Mnn1

  • Gene expression of Drosophila menin was detected by Northern blot analysis in adult and embryo as two types of transcripts, one identical in size to the cDNA, and the other larger but detected only in embryo [5].
  • We determined the nucleotide sequence of the Drosophila menin cDNA using RT-PCR and RACE, and confirmed it by direct sequencing of genomic DNA [5].
  • The Drosophila menin gene was composed of five exons in which the protein was encoded in exon 2 through 5, and spanned approximately 6.3 kb [5].


  1. Menin is a regulator of the stress response in Drosophila melanogaster. Papaconstantinou, M., Wu, Y., Pretorius, H.N., Singh, N., Gianfelice, G., Tanguay, R.M., Campos, A.R., Bédard, P.A. Mol. Cell. Biol. (2005) [Pubmed]
  2. Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1. Busygina, V., Suphapeetiporn, K., Marek, L.R., Stowers, R.S., Xu, T., Bale, A.E. Hum. Mol. Genet. (2004) [Pubmed]
  3. Genetic interactions between Drosophila melanogaster menin and Jun/Fos. Cerrato, A., Parisi, M., Anna, S.S., Missirlis, F., Guru, S., Agarwal, S., Sturgill, D., Talbot, T., Spiegel, A., Collins, F., Chandrasekharappa, S., Marx, S., Oliver, B. Dev. Biol. (2006) [Pubmed]
  4. Characterization of a MEN1 ortholog from Drosophila melanogaster. Guru, S.C., Prasad, N.B., Shin, E.J., Hemavathy, K., Lu, J., Ip, Y.T., Agarwal, S.K., Marx, S.J., Spiegel, A.M., Collins, F.S., Oliver, B., Chandrasekharappa, S.C. Gene (2001) [Pubmed]
  5. Complementary DNA structure and genomic organization of Drosophila menin. Maruyama, K., Tsukada, T., Honda, M., Nara-Ashizawa, N., Noguchi, K., Cheng, J., Ohkura, N., Sasaki, K., Yamaguchi, K. Mol. Cell. Endocrinol. (2000) [Pubmed]
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