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MeSH Review

Multiple Endocrine Neoplasia

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Disease relevance of Multiple Endocrine Neoplasia


High impact information on Multiple Endocrine Neoplasia


Chemical compound and disease context of Multiple Endocrine Neoplasia


Biological context of Multiple Endocrine Neoplasia


Anatomical context of Multiple Endocrine Neoplasia


Gene context of Multiple Endocrine Neoplasia


Analytical, diagnostic and therapeutic context of Multiple Endocrine Neoplasia


  1. Cushing's syndrome due to ectopic ACTH secretion by bilateral pheochromocytomas in multiple endocrine neoplasia type 2A. Mendonça, B.B., Arnhold, I.J., Nicolau, W., Avancini, V.A., Boise, W. N. Engl. J. Med. (1988) [Pubmed]
  2. Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2. Eisenhofer, G., Lenders, J.W., Linehan, W.M., Walther, M.M., Goldstein, D.S., Keiser, H.R. N. Engl. J. Med. (1999) [Pubmed]
  3. Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome. Pipeleers-Marichal, M., Somers, G., Willems, G., Foulis, A., Imrie, C., Bishop, A.E., Polak, J.M., Häcki, W.H., Stamm, B., Heitz, P.U. N. Engl. J. Med. (1990) [Pubmed]
  4. Mutations of the RET proto-oncogene in Hirschsprung's disease. Edery, P., Lyonnet, S., Mulligan, L.M., Pelet, A., Dow, E., Abel, L., Holder, S., Nihoul-Fékété, C., Ponder, B.A., Munnich, A. Nature (1994) [Pubmed]
  5. Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene: Role of Rho GTPase and menin. Varro, A., Hemers, E., Archer, D., Pagliocca, A., Haigh, C., Ahmed, S., Dimaline, R., Dockray, G.J. Gastroenterology (2002) [Pubmed]
  6. Somatic mutation of the MEN1 gene in parathyroid tumours. Heppner, C., Kester, M.B., Agarwal, S.K., Debelenko, L.V., Emmert-Buck, M.R., Guru, S.C., Manickam, P., Olufemi, S.E., Skarulis, M.C., Doppman, J.L., Alexander, R.H., Kim, Y.S., Saggar, S.K., Lubensky, I.A., Zhuang, Z., Liotta, L.A., Chandrasekharappa, S.C., Collins, F.S., Spiegel, A.M., Burns, A.L., Marx, S.J. Nat. Genet. (1997) [Pubmed]
  7. Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1. Friedman, E., Sakaguchi, K., Bale, A.E., Falchetti, A., Streeten, E., Zimering, M.B., Weinstein, L.S., McBride, W.O., Nakamura, Y., Brandi, M.L. N. Engl. J. Med. (1989) [Pubmed]
  8. Parathyroid mitogenic activity in plasma from patients with familial multiple endocrine neoplasia type 1. Brandi, M.L., Aurbach, G.D., Fitzpatrick, L.A., Quarto, R., Spiegel, A.M., Bliziotes, M.M., Norton, J.A., Doppman, J.L., Marx, S.J. N. Engl. J. Med. (1986) [Pubmed]
  9. Multiple endocrine adenomatosis type I. Occurrence in an octogenarian with high levels of circulating pancreatic polypeptide. Gelston, A.L., Delisle, M.B., Patel, Y.C. JAMA (1982) [Pubmed]
  10. Multiple endocrine adenomatosis type IIb. Diagnosis and treatment. Block, M.B., Roberts, J.P., Kadair, R.G., Seyfer, A.E., Hull, S.F., Nofeldt, F.D. JAMA (1975) [Pubmed]
  11. Phenotype-genotype correlation in Hirschsprung disease is illuminated by comparative analysis of the RET protein sequence. Kashuk, C.S., Stone, E.A., Grice, E.A., Portnoy, M.E., Green, E.D., Sidow, A., Chakravarti, A., McCallion, A.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  12. A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A. Höppner, W., Ritter, M.M. Hum. Mol. Genet. (1997) [Pubmed]
  13. Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. Agarwal, S.K., Kester, M.B., Debelenko, L.V., Heppner, C., Emmert-Buck, M.R., Skarulis, M.C., Doppman, J.L., Kim, Y.S., Lubensky, I.A., Zhuang, Z., Green, J.S., Guru, S.C., Manickam, P., Olufemi, S.E., Liotta, L.A., Chandrasekharappa, S.C., Collins, F.S., Spiegel, A.M., Burns, A.L., Marx, S.J. Hum. Mol. Genet. (1997) [Pubmed]
  14. Loss of heterozygosity of markers on chromosome 11 in tumors from patients with multiple endocrine neoplasia syndrome type 1. Radford, D.M., Ashley, S.W., Wells, S.A., Gerhard, D.S. Cancer Res. (1990) [Pubmed]
  15. Measurement of urinary epinephrine in screening for pheochromocytoma in multiple endocrine neoplasia type II. Hamilton, B.P., Landsberg, L., Levine, R.J. Am. J. Med. (1978) [Pubmed]
  16. A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Hofstra, R.M., Landsvater, R.M., Ceccherini, I., Stulp, R.P., Stelwagen, T., Luo, Y., Pasini, B., Höppener, J.W., van Amstel, H.K., Romeo, G. Nature (1994) [Pubmed]
  17. Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations. Thakker, R.V., Pook, M.A., Wooding, C., Boscaro, M., Scanarini, M., Clayton, R.N. J. Clin. Invest. (1993) [Pubmed]
  18. Altered expression of RET proto-oncogene product in prostatic intraepithelial neoplasia and prostate cancer. Dawson, D.M., Lawrence, E.G., MacLennan, G.T., Amini, S.B., Kung, H.J., Robinson, D., Resnick, M.I., Kursh, E.D., Pretlow, T.P., Pretlow, T.G. J. Natl. Cancer Inst. (1998) [Pubmed]
  19. Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B. Carlson, K.M., Dou, S., Chi, D., Scavarda, N., Toshima, K., Jackson, C.E., Wells, S.A., Goodfellow, P.J., Donis-Keller, H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  20. Functional analysis of RET with Hirschsprung mutations affecting its kinase domain. Iwashita, T., Kurokawa, K., Qiao, S., Murakami, H., Asai, N., Kawai, K., Hashimoto, M., Watanabe, T., Ichihara, M., Takahashi, M. Gastroenterology (2001) [Pubmed]
  21. Polymorphisms in RET and its coreceptors and ligands as genetic modifiers of multiple endocrine neoplasia type 2A. Lesueur, F., Cebrian, A., Robledo, M., Niccoli-Sire, P., Svensson, K.A., Pinson, S., Leyland, J., Whittaker, J., Pharoah, P.D., Ponder, B.A. Cancer Res. (2006) [Pubmed]
  22. Prognostic value of initial fasting serum gastrin levels in patients with Zollinger-Ellison syndrome. Berger, A.C., Gibril, F., Venzon, D.J., Doppman, J.L., Norton, J.A., Bartlett, D.L., Libutti, S.K., Jensen, R.T., Alexander, H.R. J. Clin. Oncol. (2001) [Pubmed]
  23. Proliferation of endothelial component of parathyroid gland in multiple endocrine neoplasia type 1. Potential relationship with a mitogenic factor. D'Adda, T., Amorosi, A., Bussolati, G., Brandi, M.L., Bordi, C. Am. J. Pathol. (1993) [Pubmed]
  24. Biological effects of the dual phenotypic Janus mutation of ret cosegregating with both multiple endocrine neoplasia type 2 and Hirschsprung's disease. Arighi, E., Popsueva, A., Degl'Innocenti, D., Borrello, M.G., Carniti, C., Perälä, N.M., Pierotti, M.A., Sariola, H. Mol. Endocrinol. (2004) [Pubmed]
  25. A model for GFR alpha 4 function and a potential modifying role in multiple endocrine neoplasia 2. Vanhorne, J.B., Andrew, S.D., Harrison, K.J., Taylor, S.A., Thomas, B., McDonald, T.J., Ainsworth, P.J., Mulligan, L.M. Oncogene (2005) [Pubmed]
  26. Intronic single nucleotide polymorphisms in the RET protooncogene are associated with a subset of apparently sporadic pheochromocytoma and may modulate age of onset. McWhinney, S.R., Boru, G., Binkley, P.K., Peczkowska, M., Januszewicz, A.A., Neumann, H.P., Eng, C. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  27. Molecular analysis of the ret and GDNF genes in a family with multiple endocrine neoplasia type 2A and Hirschsprung disease. Borrego, S., Eng, C., Sánchez, B., Sáez, M.E., Navarro, E., Antiñolo, G. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  28. The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. Kedra, D., Seroussi, E., Fransson, I., Trifunovic, J., Clark, M., Lagercrantz, J., Blennow, E., Mehlin, H., Dumanski, J. Hum. Genet. (1997) [Pubmed]
  29. Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). Forbes, S.A., Pannett, A.A., Bassett, J.H., Harding, B., Wooding, C., Thakker, R.V., Butler, R., Ogilvie, D., Anand, R., Gaudray, P., Weber, G., Larsson, C., Zhang, C.X., Calender, A., Höppener, J.W., Lips, C.J., Kas, K. Hum. Genet. (1997) [Pubmed]
  30. Primary hyperparathyroidism in familial multiple endocrine neoplasia type I. Long-term follow-up of serum calcium levels after parathyroidectomy. Rizzoli, R., Green, J., Marx, S.J. Am. J. Med. (1985) [Pubmed]
  31. Diagnosis of multiple endocrine neoplasia [MEN] 2A, 2B and familial medullary thyroid cancer [FMTC] by multiplex PCR and heteroduplex analyses of RET proto-oncogene mutations. Kambouris, M., Jackson, C.E., Feldman, G.L. Hum. Mutat. (1996) [Pubmed]
  32. Plasma chromogranin A in patients with multiple endocrine neoplasia type 1. Granberg, D., Stridsberg, M., Seensalu, R., Eriksson, B., Lundqvist, G., Oberg, K., Skogseid, B. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  33. Non-islet origin of pancreatic islet cell tumors. Vortmeyer, A.O., Huang, S., Lubensky, I., Zhuang, Z. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  34. Current management of Zollinger-Ellison syndrome. Jensen, R.T., Maton, P.N., Gardner, J.D. Drugs (1986) [Pubmed]
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