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Gene Review

kay  -  kayak

Drosophila melanogaster

Synonyms: AP-1, AP1, CG15507, CG15509, CG33956, ...
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Disease relevance of kay


High impact information on kay

  • Common and distinct roles of DFos and DJun during Drosophila development [2].
  • This study establishes a direct link among JNK signaling, DFos phosphorylation, chromatin modification, and AP-1-dependent transcription and its importance in a developing organism [3].
  • Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites [4].
  • Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation [5].
  • This effect requires Fos-dependent transcriptional activation of a matrix metalloprotease gene mmp1 downstream of JNK [6].

Biological context of kay


Anatomical context of kay


Associations of kay with chemical compounds


Physical interactions of kay


Enzymatic interactions of kay

  • Drosophila JNK and ERK phosphorylate D-Fos with overlapping, but distinct, patterns [4].

Regulatory relationships of kay


Other interactions of kay

  • Strikingly, decreased or increased puc function leads to a corresponding increase or decrease, respectively, of Fos and Jun protein levels [8].
  • Consistent with this, overexpression of a dominant negative DRac1 resulted in lower levels of Fos/Jun [8].
  • This suggests that Puc acts downstream of the JNK pathway and D-Fos to mediate a negative feed-back loop [12].
  • D-Fos, a target gene of Decapentaplegic signalling with a critical role during Drosophila endoderm induction [18].
  • In overexpression assays, Pk1 is able to activate AP-1-mediated transcription and inhibit activation of Wnt/beta-catenin signaling [19].

Analytical, diagnostic and therapeutic context of kay

  • High molecular weight DNA-protein complexes on an oligonucleotide probe spanning the AP-1 binding site were identified in gel retardation assays using partially purified bacterially expressed Djun protein or nuclear extracts from Drosophila embryos [15].
  • To gain further insight into the function and the regulation of this gene, we have investigated the expression pattern of the two kay mRNA isoforms, kay-RA and kay-RB, during oogenesis and embryogenesis by whole-mount in situ hybridization [20].
  • The RNA interference-mediated inhibition of Fos in proliferating cells of the wing and eye discs resulted in a specific defect in the G(2)-to-M-phase transition, while cell growth remained unimpaired, resulting in a marked reduction in organ size [21].


  1. SP3 and AP-1 mediate transcriptional activation of the lamin A proximal promoter. Muralikrishna, B., Parnaik, V.K. Eur. J. Biochem. (2001) [Pubmed]
  2. Common and distinct roles of DFos and DJun during Drosophila development. Riesgo-Escovar, J.R., Hafen, E. Science (1997) [Pubmed]
  3. Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis. Miotto, B., Sagnier, T., Berenger, H., Bohmann, D., Pradel, J., Graba, Y. Genes Dev. (2006) [Pubmed]
  4. Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Ciapponi, L., Jackson, D.B., Mlodzik, M., Bohmann, D. Genes Dev. (2001) [Pubmed]
  5. Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. Luo, X., Puig, O., Hyun, J., Bohmann, D., Jasper, H. EMBO J. (2007) [Pubmed]
  6. JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. Uhlirova, M., Bohmann, D. EMBO J. (2006) [Pubmed]
  7. Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants. Zeitlinger, J., Kockel, L., Peverali, F.A., Jackson, D.B., Mlodzik, M., Bohmann, D. EMBO J. (1997) [Pubmed]
  8. Drosophila puckered regulates Fos/Jun levels during follicle cell morphogenesis. Dobens, L.L., Martín-Blanco, E., Martínez-Arias, A., Kafatos, F.C., Raftery, L.A. Development (2001) [Pubmed]
  9. Response of Djun and Dfos mRNA abundance to signal transduction pathways in cultured cells of Drosophila melanogaster. Xia, X., Goldstein, E.S. Mol. Biol. Rep. (1999) [Pubmed]
  10. Top-DER- and Dpp-dependent requirements for the Drosophila fos/kayak gene in follicular epithelium morphogenesis. Dequier, E., Souid, S., Pál, M., Maróy, P., Lepesant, J.A., Yanicostas, C. Mech. Dev. (2001) [Pubmed]
  11. AP-1, but not NF-kappa B, is required for efficient steroid-triggered cell death in Drosophila. Lehmann, M., Jiang, C., Ip, Y.T., Thummel, C.S. Cell Death Differ. (2002) [Pubmed]
  12. Thorax closure in Drosophila: involvement of Fos and the JNK pathway. Zeitlinger, J., Bohmann, D. Development (1999) [Pubmed]
  13. Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila. Jindra, M., Gaziova, I., Uhlirova, M., Okabe, M., Hiromi, Y., Hirose, S. EMBO J. (2004) [Pubmed]
  14. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Han, Z.S., Enslen, H., Hu, X., Meng, X., Wu, I.H., Barrett, T., Davis, R.J., Ip, Y.T. Mol. Cell. Biol. (1998) [Pubmed]
  15. An AP-1 binding site in the upstream region of Deb-A is part of a developmentally regulated negative element. Wang, G.L., Goldstein, E.S. Biochim. Biophys. Acta (1993) [Pubmed]
  16. An autoregulatory function of Dfos during Drosophila endoderm induction. Szüts, D., Bienz, M. Mech. Dev. (2000) [Pubmed]
  17. Transcription of Dfos is stimulated by brain tumours of l(2)gl-deficient larvae of Drosophila melanogaster. Nedelcheva, M., Topouzova, T., Genova, G. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  18. D-Fos, a target gene of Decapentaplegic signalling with a critical role during Drosophila endoderm induction. Riese, J., Tremml, G., Bienz, M. Development (1997) [Pubmed]
  19. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Veeman, M.T., Slusarski, D.C., Kaykas, A., Louie, S.H., Moon, R.T. Curr. Biol. (2003) [Pubmed]
  20. Differential expression of the two Drosophila fos/kayak transcripts during oogenesis and embryogenesis. Souid, S., Yanicostas, C. Dev. Dyn. (2003) [Pubmed]
  21. Control of g2/m transition by Drosophila fos. Hyun, J., B??cam, I., Yanicostas, C., Bohmann, D. Mol. Cell. Biol. (2006) [Pubmed]
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