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Chemical Compound Review

Ecdysterone     (2S,3R,5R,9R,10R,13R,14S,17S)- 2,3,14...

Synonyms: Ekdisten, Ecdysteron, Commisterone, Crustecdyson, Crustecdysone, ...
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High impact information on Ecdysterone


Biological context of Ecdysterone


Anatomical context of Ecdysterone


Associations of Ecdysterone with other chemical compounds


Gene context of Ecdysterone

  • Exposure of the mature larval epidermis to 20-OH-ecdysone caused a rapid accumulation of DDC transcripts [19].
  • It is proposed that the activity of the 20-OH-ecdysone inducible puff 74EF leads to a switch in the synthesis of a transcription factor [20].
  • We identified in Dictyostelium a gene snwA containing a region of similarity to SH2 domains of higher eukaryotes. snwA is homologous to a novel human gene SNW1 and to Bx42 from Drosophila melanogaster, a gene coding for a chromatin binding protein responsive to 20-OH-ecdysone. snwA has one mRNA transcript of an approximate size of 2.5 kb [21].
  • These results are discussed in terms of a model in which beta-ecdysone affects the distribution of tubulin in "assembly-active" and "assembly-inactive" pools [22].
  • Ecdysterone increases the level of the P1 transcript, but not of the P6 transcript, in ecdysterone-deficient ecd1 larvae [23].

Analytical, diagnostic and therapeutic context of Ecdysterone


  1. Induction of acetylcholinesterase activity by beta-ecdysone in a Drosophila cell line. Cherbas, P., Cherbas, L., Williams, C.M. Science (1977) [Pubmed]
  2. The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation. Hock, T., Cottrill, T., Keegan, J., Garza, D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Effect of insect hormones on RNA polymerases of mass-isolated imaginal discs of Drosophila melanogaster cultured in vitro. Nishiura, J.T., Fristrom, J.W. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  4. Modulation of novel-length DOPA decarboxylase transcripts by 20-OH-ecdysone in a Drosophila melanogaster Kc cell subline. Swiderski, R.E., O'Connor, J.D. Mol. Cell. Biol. (1986) [Pubmed]
  5. Preparation of an ecdysone immunogen for radioimmunoassay work. Hung, D.T., Benner, S.A., Williams, C.M. J. Biol. Chem. (1980) [Pubmed]
  6. A member of the steroid hormone receptor gene family is expressed in the 20-OH-ecdysone inducible puff 75B in Drosophila melanogaster. Feigl, G., Gram, M., Pongs, O. Nucleic Acids Res. (1989) [Pubmed]
  7. Molecular study of the retrovirus-like transposable element 412, a 20-OH ecdysone responsive repetitive sequence in Drosophila cultured cells. Micard, D., Couderc, J.L., Sobrier, M.L., Giraud, G., Dastugue, B. Nucleic Acids Res. (1988) [Pubmed]
  8. 20-OH-ecdysone regulates 60 C beta tubulin gene expression in Kc cells and during Drosophila development. Sobrier, M.L., Chapel, S., Couderc, J.L., Micard, D., Lecher, P., Somme-Martin, G., Dastugue, B. Exp. Cell Res. (1989) [Pubmed]
  9. The mechanism of C-20 hydroxylation of alpha-ecdysone in the desert locust, Schistocerca gregaria. Johnson, P., Rees, H.H. Biochem. J. (1977) [Pubmed]
  10. Selective activation of RNA polymerase I in fat body nuclei of Sarcophaga peregrina larvae by beta-ecdysone. Natori, S. Dev. Biol. (1976) [Pubmed]
  11. 20-OH-ecdysone swells nuclear volume by alkalinization in salivary glands of Drosophila melanogaster. Wünsch, S., Schneider, S., Schwab, A., Oberleithner, H. Cell Tissue Res. (1993) [Pubmed]
  12. Production of specific-protein secretion granules by fat body cells of the blowfly, Calliphora erythrocephala. Substitution of an ovarian key factor by beta-ecdysone. Thomsen, E., Thomsen, M. Cell Tissue Res. (1978) [Pubmed]
  13. Functional significance of parasitism-induced suppression of juvenile hormone esterase activity in developmentally delayed Choristoneura fumiferana larvae. Cusson, M., Laforge, M., Miller, D., Cloutier, C., Stoltz, D. Gen. Comp. Endocrinol. (2000) [Pubmed]
  14. 20 (OH) ecdysone-induced transition from intermolt to premolt protein biosynthesis patterns in the hypodermis of the crayfish, Astacus leptodactylus, in vitro. Traub, M., Gellissen, G., Spindler, K.D. Gen. Comp. Endocrinol. (1987) [Pubmed]
  15. Hormonal regulation of dopa decarboxylase during a larval molt. Hiruma, K., Riddiford, L.M. Dev. Biol. (1985) [Pubmed]
  16. Ecdysteroid resistant subclones of the epithelial cell line from Chironomus tentans (Insecta, Diptera). I. Selection and characterization of resistant clones. Spindler-Barth, M., Spindler, K.D. In Vitro Cell. Dev. Biol. Anim. (1998) [Pubmed]
  17. Methoprene and 20-OH-ecdysone affect male production in Daphnia pulex. Peterson, J.K., Kashian, D.R., Dodson, S.I. Environ. Toxicol. Chem. (2001) [Pubmed]
  18. The effect of precocene II and 20-OH-ecdysone on Litomosoides carinii and Dipetalonema viteae in vivo. Mehlhorn, H., Spindler, K.D., Spindler-Barth, M., Walldorf, V., Andrews, P., Thomas, H. Zeitschrift für Parasitenkunde (Berlin, Germany) (1986) [Pubmed]
  19. Differential responses of the dopa decarboxylase gene to 20-OH-ecdysone in Drosophila melanogaster. Clark, W.C., Doctor, J., Fristrom, J.W., Hodgetts, R.B. Dev. Biol. (1986) [Pubmed]
  20. Characterization of a putative transcription factor gene expressed in the 20-OH-ecdysone inducible puff 74EF in Drosophila melanogaster. Janknecht, R., Taube, W., Lüdecke, H.J., Pongs, O. Nucleic Acids Res. (1989) [Pubmed]
  21. The homolog of chromatin binding protein Bx42 identified in Dictyostelium. Folk, P., Půta, F., Krpejsová, L., Blahůsková, A., Markos, A., Rabino, M., Dottin, R.P. Gene (1996) [Pubmed]
  22. Tubulin content and synthesis in differentiating Drosophila cells in culture. Berger, E.M., Sloboda, R.D., Ireland, R.C. Cell Motil. (1980) [Pubmed]
  23. Developmentally regulated gene expression in Drosophila larval fat bodies. Lepesant, J.A., Levine, M., Garen, A., Lepesant-Kejzlarvoa, J., Rat, L., Somme-Martin, G. J. Mol. Appl. Genet. (1982) [Pubmed]
  24. Separation and detection of alpha- and beta-ecdysone using thin-layer chromatography. Ruh, M.F., Black, C. J. Chromatogr. (1976) [Pubmed]
  25. Ecdysteroid levels during embryogenesis in the shrimp, Palaemon serratus (Crustacea Decapoda): quantitative and qualitative changes. Spindler, K.D., Van Wormhoudt, A., Sellos, D., Spindler-Barth, M. Gen. Comp. Endocrinol. (1987) [Pubmed]
  26. Immunohistochemical localization of ecdysteroid receptor and ultraspiracle in the epithelial cell line from Chironomus tentans (Insecta, Diptera). Lammerding-Köppel, M., Spindler-Barth, M., Steiner, E., Lezzi, M., Drews, U., Spindler, K.D. Tissue & cell. (1998) [Pubmed]
  27. Alterations in ecdysone content during the post-embryonic development of Chironomus thummi: correlations with chromosomal puffing. Valentin, M., Bollenbacher, W.E., Gilbert, L.I., Kroeger, H. Z. Naturforsch., C, Biosci. (1978) [Pubmed]
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