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Gene Review

Nup154  -  Nucleoporin 154kD

Drosophila melanogaster

Synonyms: BcDNA:LD21772, CG4579, Dmel\CG4579, Nup, Nup155, ...
 
 
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High impact information on Nup154

 

Anatomical context of Nup154

  • In mutant egg chambers the Nup154 protein accumulated in the cytoplasm, while it was only barely detected at the nuclear envelopes [1].
  • In ovaries, Nup154 was essential for egg chamber development and oocyte growth [1].
  • This suggests that Nup154 could be required for localizing other nucleoporins within the nuclear pore complex, as previously demonstrated for the yeast Nup170 [1].
  • Two additional nup154 alleles also associated with different P-element inserts in the 5'-UTR were viable but had strong loss-of-function sterile phenotypes, including failure to maintain spermatogenic stem cells and failure to progress into vitellogenic stages of oogenesis [2].

References

  1. Nup154, a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene. Gigliotti, S., Callaini, G., Andone, S., Riparbelli, M.G., Pernas-Alonso, R., Hoffmann, G., Graziani, F., Malva, C. J. Cell Biol. (1998) [Pubmed]
  2. Developmental genetics of the essential Drosophila nucleoporin nup154: allelic differences due to an outward-directed promoter in the P-element 3' end. Kiger, A.A., Gigliotti, S., Fuller, M.T. Genetics (1999) [Pubmed]
 
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