High impact information on Ast-C

• The peptides align to a hormone precursor sequence of the Drosophila genome data base and are almost identical to allatostatin C from Manduca sexta [1].
• Drosophila melanogaster flatline encodes a myotropin orthologue to Manduca sexta allatostatin [2].
• FLT does not act as an allatostatin [2].
• Despite its profound myotropic effect, pupae injected with FLT eclosed [2].
• We identified a Drosophila melanogaster gene encoding a peptide that dramatically decreases spontaneous muscle contractions and, correspondingly, named the peptide flatline (FLT) [2].

Biological context of Ast-C

• The DAP-C gene has three introns and four exons and is located at position 32D2-3 on the left arm of the second chromosome [3].
• DMS, FLT, and SDNFMRFamide each decreases heart rate; however, their effects are profoundly different [4].

Associations of Ast-C with chemical compounds

• In addition, the spatial and temporal distributions of DMS, FLT, and SDNFMRFamide are dissimilar [4].

Other interactions of Ast-C

• In situ tissue hybridization further suggests FLT is a novel brain-gut peptide and specifically, the measured activity indicates that it is a potent myotropin [2].
• For the tachykinin precursor, the ecdysis-triggering hormone precursor and the allatostatin-C precursor, translation of the predicted neuropeptides in neural tissues was confirmed with mass spectrometric techniques [5].

References