The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Capa  -  Capability

Drosophila melanogaster

Synonyms: CAP, CAP-2b, CAP2B-1, CAP2B-2, CAP2B-3, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of capa

  • By immunocytochemistry, we identified four pairs of neuroendocrine cells likely to release the capa peptides into the hemolymph: one pair in the subesophageal ganglion and the other three in the abdominal neuromeres [1].
  • This manifests itself as hypersensitivity of epithelial fluid transport to the nitridergic neuropeptide, capa-1, which acts through nitric oxide and cGMP [2].
 

High impact information on capa

 

Anatomical context of capa

 

Associations of capa with chemical compounds

  • In D. melanogaster Malpighian (renal) tubules, the capa peptides stimulate production of nitric oxide (NO) and guanosine 3', 5'-cyclic monophosphate (cGMP), resulting in increased fluid transport [10].
  • By contrast, either cyclic AMP or cyclic GMP (upon CAP2b stimulation) acts on the electrogenic cation-transporting apical V-ATPase, with only a negligible effect on anion conductance and without perturbing intracellular [Ca2+] [11].
  • The cell-permeant Ca2+ chelator BAPTA-AM was shown to suppress the action of leucokinins (insect peptides that induce rapid fluid secretion), but not those of cyclic AMP, the neuronally derived insect peptide cardioacceleratory peptide 2b (CAP2b) or its intracellular messenger cyclic GMP [11].
  • These data indicate that CAP2b stimulates NOS and therefore, endogenous NO production, which, in turn, stimulates a soluble guanylate cyclase [9].
 

Other interactions of capa

  • Because capa-1 and -2 and related insect neuropeptides stimulate fluid secretion in insect Malpighian (renal) tubules, the identification of this first insect capa receptor will advance our knowledge on insect renal function [12].
  • In situ tissue hybridization further suggests FLT is a novel brain-gut peptide and specifically, the measured activity indicates that it is a potent myotropin [13].
  • Therefore, it was of interest to investigate if CAP2b acts through NO in isolated tubules and thus presumably through stimulation of a tubule NO synthase (NOS) [9].
 

Analytical, diagnostic and therapeutic context of capa

References

  1. Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster. Kean, L., Cazenave, W., Costes, L., Broderick, K.E., Graham, S., Pollock, V.P., Davies, S.A., Veenstra, J.A., Dow, J.A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  2. The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase. MacPherson, M.R., Broderick, K.E., Graham, S., Day, J.P., Houslay, M.D., Dow, J.A., Davies, S.A. J. Exp. Biol. (2004) [Pubmed]
  3. Analysis of Drosophila cGMP-dependent protein kinases and assessment of their in vivo roles by targeted expression in a renal transporting epithelium. MacPherson, M.R., Lohmann, S.M., Davies, S.A. J. Biol. Chem. (2004) [Pubmed]
  4. Model organisms: new insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster. MacPherson, M.R., Pollock, V.P., Broderick, K.E., Kean, L., O'Connell, F.C., Dow, J.A., Davies, S.A. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  5. Amino acid sequence of CAP2b, an insect cardioacceleratory peptide from the tobacco hawkmoth Manduca sexta. Huesmann, G.R., Cheung, C.C., Loi, P.K., Lee, T.D., Swiderek, K.M., Tublitz, N.J. FEBS Lett. (1995) [Pubmed]
  6. The Drosophila gene CG9918 codes for a pyrokinin-1 receptor. Cazzamali, G., Torp, M., Hauser, F., Williamson, M., Grimmelikhuijzen, C.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  7. Pyrokinin/PBAN-like peptides in the central nervous system of Drosophila melanogaster. Choi, M.Y., Rafaeli, A., Jurenka, R.A. Cell Tissue Res. (2001) [Pubmed]
  8. CAP2b, a cardioacceleratory peptide, is present in Drosophila and stimulates tubule fluid secretion via cGMP. Davies, S.A., Huesmann, G.R., Maddrell, S.H., O'Donnell, M.J., Skaer, N.J., Dow, J.A., Tublitz, N.J. Am. J. Physiol. (1995) [Pubmed]
  9. Neuropeptide stimulation of the nitric oxide signaling pathway in Drosophila melanogaster Malpighian tubules. Davies, S.A., Stewart, E.J., Huesmann, G.R., Skaer, N.J., Maddrell, S.H., Tublitz, N.J., Dow, J.A. Am. J. Physiol. (1997) [Pubmed]
  10. Conservation of capa peptide-induced nitric oxide signalling in Diptera. Pollock, V.P., McGettigan, J., Cabrero, P., Maudlin, I.M., Dow, J.A., Davies, S.A. J. Exp. Biol. (2004) [Pubmed]
  11. Separate control of anion and cation transport in malpighian tubules of Drosophila Melanogaster. O'Donnell, M.J., Dow, J.A., Huesmann, G.R., Tublitz, N.J., Maddrell, S.H. J. Exp. Biol. (1996) [Pubmed]
  12. Molecular cloning and functional expression of a Drosophila receptor for the neuropeptides capa-1 and -2. Iversen, A., Cazzamali, G., Williamson, M., Hauser, F., Grimmelikhuijzen, C.J. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  13. Drosophila melanogaster flatline encodes a myotropin orthologue to Manduca sexta allatostatin. Price, M.D., Merte, J., Nichols, R., Koladich, P.M., Tobe, S.S., Bendena, W.G. Peptides (2002) [Pubmed]
 
WikiGenes - Universities