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Gene Review

Cyp9b2  -  Cytochrome P450-9b2

Drosophila melanogaster

Synonyms: 9b2, BEST:GH08116, CG4486, CYPIXB2, Cytochrome P450 9b2, ...
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High impact information on Cyp9b2

  • Waters and colleagues recently suggested [Waters, L. C., Zelhof, A. C., Shaw, B. J. & Ch'ang, L.-Y. (1992) Proc. Natl. Acad. Sci. USA 89, 4855-4859] that an insertion of a long terminal repeat of transposable element 17.6 into the 3' untranslated region of a P450 gene leads to susceptibility to the insecticide DDT in Drosophila melanogaster [1].
  • (i) The effect of a specific P450 inhibitor, piperonyl butoxide, on larval survival through eclosion on each cactus substrate was investigated [2].
  • Immunoblot analyses of mature and regressed corpora lutea indicated a parallel expression of Ad4BP and side-chain cleavage P-450, and both proteins significantly decreased in the regressed tissues [3].
  • Ad4BP, a zinc finger DNA-binding protein, was identified as a transcription factor regulating steroidogenic P-450 genes in a cAMP-dependent manner [3].
  • P450-dependent bioactivation of Tris-BP [4].

Biological context of Cyp9b2


Associations of Cyp9b2 with chemical compounds

  • The concentrations of these labdane diterpenes required to elicit a 50% inhibition of the cytochrome P-450 dependent steroid hydroxylase activity in the insect tissues ranged from approximately 5 x 10(-6) to 5 x 10(-4) M [6].
  • Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity [6].


  1. Noninvolvement of the long terminal repeat of transposable element 17.6 in insecticide resistance in Drosophila. Delpuech, J.M., Aquadro, C.F., Roush, R.T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Involvement of cytochrome P450 in host-plant utilization by Sonoran Desert Drosophila. Frank, M.R., Fogleman, J.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues. Morohashi, K., Iida, H., Nomura, M., Hatano, O., Honda, S., Tsukiyama, T., Niwa, O., Hara, T., Takakusu, A., Shibata, Y. Mol. Endocrinol. (1994) [Pubmed]
  4. Genotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate in the rat and Drosophila: effects of deuterium substitution. van Beerendonk, G.J., Nivard, M.J., Vogel, E.W., Nelson, S.D., Meerman, J.H. Carcinogenesis (1994) [Pubmed]
  5. Improved high bioactivation cross for the wing somatic mutation and recombination test in Drosophila melanogaster. Graf, U., van Schaik, N. Mutat. Res. (1992) [Pubmed]
  6. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Keogh, D.P., Mitchell, M.J., Crooks, J.R., Smith, S.L. Experientia (1992) [Pubmed]
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