The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

sgl  -  sugarless

Drosophila melanogaster

Synonyms: 8310, BG01214, CG10072, Dmel\CG10072, Protein sugarless, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of sgl

  • Overexpression of sgl in E. coli resulted in synthesis of a protein with high levels of UDPGDH activity [1].

High impact information on sgl


Biological context of sgl


Anatomical context of sgl


Associations of sgl with chemical compounds


Other interactions of sgl

  • We report here the biochemical characterization of glycosaminoglycans in Drosophila bearing mutations in sugarless, sulfateless, and tout-velu [8].
  • Further analysis of two such components, sugarless and pangolin, revealed a function for these genes in late follicle cell patterning [10].


  1. The sugarless mutation affects the expression of the white eye color gene in Drosophila melanogaster. Benevolenskaya, E.V., Frolov, M.V., Birchler, J.A. Mol. Gen. Genet. (1998) [Pubmed]
  2. UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. Walsh, E.C., Stainier, D.Y. Science (2001) [Pubmed]
  3. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development. Lin, X., Buff, E.M., Perrimon, N., Michelson, A.M. Development (1999) [Pubmed]
  4. Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila. Haerry, T.E., Heslip, T.R., Marsh, J.L., O'Connor, M.B. Development (1997) [Pubmed]
  5. Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling. Binari, R.C., Staveley, B.E., Johnson, W.A., Godavarti, R., Sasisekharan, R., Manoukian, A.S. Development (1997) [Pubmed]
  6. The genetic structure of natural populations of Drosophila melanogaster XIII. Further studies on linkage disequilibrium. Mukai, T., Voelker, R.A. Genetics (1977) [Pubmed]
  7. Investigations on radiosensitive and radioresistant populations of Drosophila melanogaster. XIII. Effects of radioresistant mutants (rar) on chemical (EMS) mutagenesis. Nöthel, H., Strese, B. Mutat. Res. (1982) [Pubmed]
  8. Structural analysis of glycosaminoglycans in animals bearing mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymes. Toyoda, H., Kinoshita-Toyoda, A., Fox, B., Selleck, S.B. J. Biol. Chem. (2000) [Pubmed]
  9. The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis. Häcker, U., Lin, X., Perrimon, N. Development (1997) [Pubmed]
  10. Genome wide analysis of transcript levels after perturbation of the EGFR pathway in the Drosophila ovary. Jordan, K.C., Hatfield, S.D., Tworoger, M., Ward, E.J., Fischer, K.A., Bowers, S., Ruohola-Baker, H. Dev. Dyn. (2005) [Pubmed]
WikiGenes - Universities