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Gene Review

sgl  -  sugarless

Drosophila melanogaster

Synonyms: 8310, BG01214, CG10072, Dmel\CG10072, Protein sugarless, ...
 
 
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Disease relevance of sgl

  • Overexpression of sgl in E. coli resulted in synthesis of a protein with high levels of UDPGDH activity [1].
 

High impact information on sgl

 

Biological context of sgl

 

Anatomical context of sgl

 

Associations of sgl with chemical compounds

 

Other interactions of sgl

  • We report here the biochemical characterization of glycosaminoglycans in Drosophila bearing mutations in sugarless, sulfateless, and tout-velu [8].
  • Further analysis of two such components, sugarless and pangolin, revealed a function for these genes in late follicle cell patterning [10].

References

  1. The sugarless mutation affects the expression of the white eye color gene in Drosophila melanogaster. Benevolenskaya, E.V., Frolov, M.V., Birchler, J.A. Mol. Gen. Genet. (1998) [Pubmed]
  2. UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. Walsh, E.C., Stainier, D.Y. Science (2001) [Pubmed]
  3. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development. Lin, X., Buff, E.M., Perrimon, N., Michelson, A.M. Development (1999) [Pubmed]
  4. Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila. Haerry, T.E., Heslip, T.R., Marsh, J.L., O'Connor, M.B. Development (1997) [Pubmed]
  5. Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling. Binari, R.C., Staveley, B.E., Johnson, W.A., Godavarti, R., Sasisekharan, R., Manoukian, A.S. Development (1997) [Pubmed]
  6. The genetic structure of natural populations of Drosophila melanogaster XIII. Further studies on linkage disequilibrium. Mukai, T., Voelker, R.A. Genetics (1977) [Pubmed]
  7. Investigations on radiosensitive and radioresistant populations of Drosophila melanogaster. XIII. Effects of radioresistant mutants (rar) on chemical (EMS) mutagenesis. Nöthel, H., Strese, B. Mutat. Res. (1982) [Pubmed]
  8. Structural analysis of glycosaminoglycans in animals bearing mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymes. Toyoda, H., Kinoshita-Toyoda, A., Fox, B., Selleck, S.B. J. Biol. Chem. (2000) [Pubmed]
  9. The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis. Häcker, U., Lin, X., Perrimon, N. Development (1997) [Pubmed]
  10. Genome wide analysis of transcript levels after perturbation of the EGFR pathway in the Drosophila ovary. Jordan, K.C., Hatfield, S.D., Tworoger, M., Ward, E.J., Fischer, K.A., Bowers, S., Ruohola-Baker, H. Dev. Dyn. (2005) [Pubmed]
 
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