Disease relevance of sgl

• Overexpression of sgl in E. coli resulted in synthesis of a protein with high levels of UDPGDH activity [1].

High impact information on sgl

• UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish [2].
• The Drosophila sugarless and sulfateless genes encode enzymes required for the biosynthesis of heparan sulfate glycosaminoglycans [3].
• Zygotic loss of ska leads to reduced growth of imaginal discs and pattern defects similar to wg mutants [4].
• Mutations in this gene, called kiwi, generate a phenotype identical to that of wingless [5].
• UDP-glucose dehydrogenase is required for the biosynthesis of UDP-glucuronate, which in turn is utilized in the biosynthesis of glycosaminoglycans [5].

Biological context of sgl

• The P-element insertion l(3)05007 occurs upstream of the transcription start site of the sugarless (sgl) gene and greatly reduces its transcription at various developmental stages [1].
• Investigation of a modifier locus displaying a darker eye phenotype in white-apricot flies led to the isolation of the gene encoding UDP-glucose dehydrogenase (UDPGDH) [1].
• The sugarless mutation affects the expression of the white eye color gene in Drosophila melanogaster [1].
• The genetic structure of natural populations of Drosophila melanogaster XIII. Further studies on linkage disequilibrium [6].
• Investigations on radiosensitive and radioresistant populations of Drosophila melanogaster. XIII. Effects of radioresistant mutants (rar) on chemical (EMS) mutagenesis [7].

Anatomical context of sgl

• By rescuing the kiwi phenotype with both UDP-glucuronate and the glycosaminoglycan heparan sulfate, we show that kiwi function in the embryo is crucial for the production of heparan sulfate in the extracellular matrix [5].

Associations of sgl with chemical compounds

• We find that mutations in sugarless, which encodes a protein with homology to UDP-glucose dehydrogenase, compromise the synthesis of both chondroitin and heparan sulfate, as would be predicted from a defect in UDP-glucuronate production [8].
• The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis [9].

Other interactions of sgl

• We report here the biochemical characterization of glycosaminoglycans in Drosophila bearing mutations in sugarless, sulfateless, and tout-velu [8].
• Further analysis of two such components, sugarless and pangolin, revealed a function for these genes in late follicle cell patterning [10].

References