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Gene Review

SREBF1  -  sterol regulatory element binding...

Gallus gallus

Synonyms: SREBP-1, SREBP1
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High impact information on SREBF1


Biological context of SREBF1


Analytical, diagnostic and therapeutic context of SREBF1

  • In this study, we found that in previously starved chicks, feeding a high-carbohydrate, low-fat diet stimulated a robust increase (14-fold at 5 h of feeding) in the concentration of mature SREBP-1 in liver [6].


  1. Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes. Yin, L., Zhang, Y., Hillgartner, F.B. J. Biol. Chem. (2002) [Pubmed]
  2. SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes. Zhang, Y., Yin, L., Hillgartner, F.B. J. Lipid Res. (2003) [Pubmed]
  3. ADD-1/SREBP-1 is a major determinant of tissue differential lipogenic capacity in mammalian and avian species. Gondret, F., Ferré, P., Dugail, I. J. Lipid Res. (2001) [Pubmed]
  4. Genetic linkage and expression analysis of SREBP and lipogenic genes in fat and lean chicken. Assaf, S., Lagarrigue, S., Daval, S., Sansom, M., Leclercq, B., Michel, J., Pitel, F., Alizadeh, M., Vignal, A., Douaire, M. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2004) [Pubmed]
  5. Potential role of leptin in increase of fatty acid synthase gene expression in chicken liver. Dridi, S., Buyse, J., Decuypere, E., Taouis, M. Domest. Anim. Endocrinol. (2005) [Pubmed]
  6. Starvation and feeding a high-carbohydrate, low-fat diet regulate the expression sterol regulatory element-binding protein-1 in chickens. Zhang, Y., Hillgartner, F.B. J. Nutr. (2004) [Pubmed]
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