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Gene Review

Srebf1  -  sterol regulatory element binding...

Rattus norvegicus

Synonyms: ADD-1, ADD1, Adipocyte determination-and differentiation-dependent factor 1, SREBP-1, SREBP-1c, ...
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Disease relevance of Srebf1


High impact information on Srebf1

  • In addition, KGF increased the mRNA levels of the transcription factors CCAAT/enhancer-binding protein alpha (C/EBPalpha) and C/EBPdelta as well as SREBP-1c (ADD-1), but not PPARgamma [5].
  • Finally, the liver X receptor agonist T0901317 increased acetate incorporation and SREBP-1 but not SREBP-2 protein levels [5].
  • Furthermore, KGF increased protein levels of fatty acid synthase, C/EBPalpha, C/EBPdelta, SREBP-1, epidermal fatty acid-binding protein, and SCD [5].
  • Activation of AMPK by metformin or an adenosine analogue suppresses expression of SREBP-1, a key lipogenic transcription factor [6].
  • To assess the pathogenic role of the lipogenic transcription factor, sterol regulatory element binding protein 1 (SREBP-1), we measured its mRNA in liver and islets of obese, leptin-unresponsive fa/fa Zucker diabetic fatty rats [3].

Chemical compound and disease context of Srebf1


Biological context of Srebf1


Anatomical context of Srebf1


Associations of Srebf1 with chemical compounds


Regulatory relationships of Srebf1


Other interactions of Srebf1

  • In hypophysectomized rats, in which the ADH protein increased by approximately 6-fold, the nuclear form of SREBP-1 decreased by approximately 7-fold [14].
  • These data indicate that PUFA suppress the in vivo proteolytic release of SREBP-1 and -2, but the effect on SREBP-2 is transitory, possibly reflecting the ability of PUFA to enhance cholesterol losses via bile acid synthesis [19].
  • Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements [8].
  • We concluded that SREBP-1 is unlikely to be the mediator of the early insulin effect on GK gene transcription [20].
  • Surprisingly, 3-h hyperinsulinemic clamps did not increase gastrocnemius muscle SREBP-1c and FAS mRNA levels or SREBP-1 protein levels but did increase HKII mRNA levels and decrease UCP3 mRNA levels (P < 0.05) [9].

Analytical, diagnostic and therapeutic context of Srebf1


  1. Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression. Shimizu, S., Ugi, S., Maegawa, H., Egawa, K., Nishio, Y., Yoshizaki, T., Shi, K., Nagai, Y., Morino, K., Nemoto, K., Nakamura, T., Bryer-Ash, M., Kashiwagi, A. J. Biol. Chem. (2003) [Pubmed]
  2. Calorie restriction modulates renal expression of sterol regulatory element binding proteins, lipid accumulation, and age-related renal disease. Jiang, T., Liebman, S.E., Lucia, M.S., Phillips, C.L., Levi, M. J. Am. Soc. Nephrol. (2005) [Pubmed]
  3. Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Kakuma, T., Lee, Y., Higa, M., Wang, Z., Pan, W., Shimomura, I., Unger, R.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats. Tovar, A.R., Torre-Villalvazo, I., Ochoa, M., Elías, A.L., Ortíz, V., Aguilar-Salinas, C.A., Torres, N. J. Lipid Res. (2005) [Pubmed]
  5. Keratinocyte growth factor and the transcription factors C/EBP alpha, C/EBP delta, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells. Mason, R.J., Pan, T., Edeen, K.E., Nielsen, L.D., Zhang, F., Longphre, M., Eckart, M.R., Neben, S. J. Clin. Invest. (2003) [Pubmed]
  6. Role of AMP-activated protein kinase in mechanism of metformin action. Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., Musi, N., Hirshman, M.F., Goodyear, L.J., Moller, D.E. J. Clin. Invest. (2001) [Pubmed]
  7. SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver. Chakravarty, K., Wu, S.Y., Chiang, C.M., Samols, D., Hanson, R.W. J. Biol. Chem. (2004) [Pubmed]
  8. Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements. Cagen, L.M., Deng, X., Wilcox, H.G., Park, E.A., Raghow, R., Elam, M.B. Biochem. J. (2005) [Pubmed]
  9. In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin. Commerford, S.R., Peng, L., Dubé, J.J., O'Doherty, R.M. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  10. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Tontonoz, P., Kim, J.B., Graves, R.A., Spiegelman, B.M. Mol. Cell. Biol. (1993) [Pubmed]
  11. Glucose-induced lipogenesis in pancreatic beta-cells is dependent on SREBP-1. Sandberg, M.B., Fridriksson, J., Madsen, L., Rishi, V., Vinson, C., Holmsen, H., Berge, R.K., Mandrup, S. Mol. Cell. Endocrinol. (2005) [Pubmed]
  12. Role of oleic acid as a neurotrophic factor is supported in vivo by the expression of GAP-43 subsequent to the activation of SREBP-1 and the up-regulation of stearoyl-CoA desaturase during postnatal development of the brain. Velasco, A., Tabernero, A., Medina, J.M. Brain Res. (2003) [Pubmed]
  13. Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol. Hirayama, T., Honda, A., Matsuzaki, Y., Miyazaki, T., Ikegami, T., Doy, M., Xu, G., Lea, M., Salen, G. Hepatology (2006) [Pubmed]
  14. Post-transcriptional regulation of sterol regulatory element-binding protein-1 by ethanol induces class I alcohol dehydrogenase in rat liver. He, L., Simmen, F.A., Ronis, M.J., Badger, T.M. J. Biol. Chem. (2004) [Pubmed]
  15. Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes. Matsumoto, M., Ogawa, W., Teshigawara, K., Inoue, H., Miyake, K., Sakaue, H., Kasuga, M. Diabetes (2002) [Pubmed]
  16. Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors. Boizard, M., Le Liepvre, X., Lemarchand, P., Foufelle, F., Ferré, P., Dugail, I. J. Biol. Chem. (1998) [Pubmed]
  17. Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase. Magaña, M.M., Koo, S.H., Towle, H.C., Osborne, T.F. J. Biol. Chem. (2000) [Pubmed]
  18. Soy Protein Suppresses Gene Expression of Acetyl-CoA Carboxylase Alpha from Promoter PI in Rat Liver. Aoki, H., Kimura, K., Igarashi, K., Takenaka, A. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
  19. Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms. Xu, J., Cho, H., O'Malley, S., Park, J.H., Clarke, S.D. J. Nutr. (2002) [Pubmed]
  20. Insulin regulation of glucokinase gene expression: evidence against a role for sterol regulatory element binding protein 1 in primary hepatocytes. Gregori, C., Guillet-Deniau, I., Girard, J., Decaux, J.F., Pichard, A.L. FEBS Lett. (2006) [Pubmed]
  21. Enhanced expression of hepatic lipogenic enzymes in an animal model of sedentariness. Vecchini, A., Ceccarelli, V., Orvietani, P., Caligiana, P., Susta, F., Binaglia, L., Nocentini, G., Riccardi, C., Di Nardo, P. J. Lipid Res. (2003) [Pubmed]
  22. Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle. Nadeau, K.J., Ehlers, L.B., Aguirre, L.E., Moore, R.L., Jew, K.N., Ortmeyer, H.K., Hansen, B.C., Reusch, J.E., Draznin, B. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  23. Copper deficiency induces hepatic fatty acid synthase gene transcription in rats by increasing the nuclear content of mature sterol regulatory element binding protein 1. Tang, Z., Gasperkova, D., Xu, J., Baillie, R., Lee, J.H., Clarke, S.D. J. Nutr. (2000) [Pubmed]
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