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Gene Review:

KCNJ15 - potassium channel, inwardly rectifying...

Homo sapiens

Synonyms: ATP-sensitive inward rectifier potassium channel 15, IRKK, Inward rectifier K(+) channel Kir1.3, Inward rectifier K(+) channel Kir4.2, KCNJ14, ...

Shuck, M.E. et al., Gosset, P. et al., Derst, C. et al., Fujita, A. et al., Hill, C.E. et al.

Hill, Briggs, Liu, Magtanong,

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High impact information on KCNJ15

A hyperprostaglandin E syndrome mutation in Kir1.1 (renal outer medullary potassium) channels reveals a crucial residue for channel function in Kir1.3 channels [1].
Thus we postulate that in Kir1.3 channels the extracellular positively charged lysine is of crucial functional importance [1].
Kir1.2 represents the human homolog of the rat BIRK-10 sequence, whereas Kir1.3 was unique compared with all available sequence data bases [2].
Kir1.3 was most readily detected in kidney and was also expressed in pancreas > lung [2].
In contrast, Kir1.3 expression in Xenopus oocytes was not detectable despite the fact that the cRNA efficiently directed the synthesis of a polypeptide of the expected Mr in an in vitro translation system [2].

Biological context of KCNJ15

Isolation, mapping, and sequencing of trapped exons and captured cDNAs from cosmids of this region have revealed the presence of a gene (KCNJ15) encoding a potassium (K+) channel belonging to the family of inward rectifier K+ (Kir) channels [3].
A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1) [3].
The genes that encode Kir1.2 and Kir1.3 were mapped to human chromosomes 1 and 21, respectively [2].
Comparative analysis of the predicted amino acid sequences for Kir1.2 and Kir1.3 revealed they were 62% identical [2].
Low stringency screening of a human kidney cDNA library and subsequent DNA sequence analysis identified two related K+ inward rectifier cDNAs, referred to as Kir1.2 and Kir1.3, which were derived from transcription of distinct human genes [2].

Anatomical context of KCNJ15

Among members of the inwardly rectifying K(+) channel family, we found with reverse transcriptase-polymerase chain reaction analyses that Kir4.1, Kir4.2 and Kir7.1 were expressed in rat gastric mucosa [4].
In hepatocyte couplets, Kir4.2 was predominantly localized to the basolateral membrane [5].

Other interactions of KCNJ15

Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3) [2].

References

A hyperprostaglandin E syndrome mutation in Kir1.1 (renal outer medullary potassium) channels reveals a crucial residue for channel function in Kir1.3 channels. Derst, C., Wischmeyer, E., Preisig-Müller, R., Spauschus, A., Konrad, M., Hensen, P., Jeck, N., Seyberth, H.W., Daut, J., Karschin, A. J. Biol. Chem. (1998) [Pubmed]
Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). Shuck, M.E., Piser, T.M., Bock, J.H., Slightom, J.L., Lee, K.S., Bienkowski, M.J. J. Biol. Chem. (1997) [Pubmed]
A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). Gosset, P., Ghezala, G.A., Korn, B., Yaspo, M.L., Poutska, A., Lehrach, H., Sinet, P.M., Créau, N. Genomics (1997) [Pubmed]
Specific localization of an inwardly rectifying K(+) channel, Kir4.1, at the apical membrane of rat gastric parietal cells; its possible involvement in K(+) recycling for the H(+)-K(+)-pump. Fujita, A., Horio, Y., Higashi, K., Mouri, T., Hata, F., Takeguchi, N., Kurachi, Y. J. Physiol. (Lond.) (2002) [Pubmed]
Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel. Hill, C.E., Briggs, M.M., Liu, J., Magtanong, L. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]

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