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KCNJ13  -  potassium channel, inwardly rectifying...

Homo sapiens

Synonyms: Inward rectifier K(+) channel Kir7.1, Inward rectifier potassium channel 13, KIR1.4, KIR7.1, Kir1.4, ...
 
 
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Disease relevance of KCNJ13

 

High impact information on KCNJ13

  • In situ hybridization of rat brain sections demonstrated that Kir7.1 mRNA was absent from neurons and glia but strongly expressed in the secretory epithelial cells of the choroid plexus (as confirmed by in situ patch-clamp measurements) [3].
  • When this residue was replaced by the conserved arginine in mutant Kir7.1 channels, the pronounced dependence of K+ permeability on [K+]e, characteristic for other Kir channels, was restored and the Ba2+ sensitivity was increased by a factor of approximately 25 (Ki = 27 microM) [3].
  • In cRNA-injected Xenopus oocytes Kir7.1 generated macroscopic Kir currents that showed a very shallow dependence on external K+ ([K+]e), which is in marked contrast to all other Kir channels [3].
  • At a holding potential of -100 mV, the inward current through Kir7.1 averaged -3.8 +/- 1.04 microA with 2 mM [K+]e and -4.82 +/- 1.87 microA with 96 mM [K+]e. Kir7.1 has a methionine at position 125 in the pore region where other Kir channels have an arginine [3].
  • High levels of Kir7.1 transcripts were detected in rat brain, lung, kidney, and testis [3].
 

Biological context of KCNJ13

 

Anatomical context of KCNJ13

 

Associations of KCNJ13 with chemical compounds

  • In epithelial Kir7.1 channels a non-conserved methionine in the outer pore region adjacent to the G-Y-G selectivity filter (position +2) was found to determine unique properties for permeant and blocking ions characteristic of a K(+) channel in a single-occupancy state [11].
 

Other interactions of KCNJ13

  • In the isolated RPE cells, however, Kir4.1 immunoreactivity was largely lost, while Kir7.1 immunoreactivity remained [8].
  • Our data suggest that antibodies directed against Kir7.1 and stanniocalcin-1 might serve as sensitive and specific diagnostic markers for choroid plexus tumors [1].
 

Analytical, diagnostic and therapeutic context of KCNJ13

References

  1. Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach. Hasselblatt, M., Böhm, C., Tatenhorst, L., Dinh, V., Newrzella, D., Keyvani, K., Jeibmann, A., Buerger, H., Rickert, C.H., Paulus, W. Am. J. Surg. Pathol. (2006) [Pubmed]
  2. Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region. Hasselblatt, M., Blümcke, I., Jeibmann, A., Rickert, C.H., Jouvet, A., van de Nes, J.A., Kuchelmeister, K., Brunn, A., Fevre-Montange, M., Paulus, W. Neuropathol. Appl. Neurobiol. (2006) [Pubmed]
  3. The epithelial inward rectifier channel Kir7.1 displays unusual K+ permeation properties. Döring, F., Derst, C., Wischmeyer, E., Karschin, C., Schneggenburger, R., Daut, J., Karschin, A. J. Neurosci. (1998) [Pubmed]
  4. Partial gene structure and assignment to chromosome 2q37 of the human inwardly rectifying K+ channel (Kir7.1) gene (KCNJ13). Derst, C., Döring, F., Preisig-Müller, R., Daut, J., Karschin, A., Jeck, N., Weber, S., Engel, H., Grzeschik, K.H. Genomics (1998) [Pubmed]
  5. Cellular localization of the potassium channel Kir7.1 in guinea pig and human kidney. Derst, C., Hirsch, J.R., Preisig-Müller, R., Wischmeyer, E., Karschin, A., Döring, F., Thomzig, A., Veh, R.W., Schlatter, E., Kummer, W., Daut, J. Kidney Int. (2001) [Pubmed]
  6. Inwardly rectifying K+ channel Kir7.1 is highly expressed in thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase. Nakamura, N., Suzuki, Y., Sakuta, H., Ookata, K., Kawahara, K., Hirose, S. Biochem. J. (1999) [Pubmed]
  7. Expression and permeation properties of the K(+) channel Kir7.1 in the retinal pigment epithelium. Shimura, M., Yuan, Y., Chang, J.T., Zhang, S., Campochiaro, P.A., Zack, D.J., Hughes, B.A. J. Physiol. (Lond.) (2001) [Pubmed]
  8. Functional Kir7.1 channels localized at the root of apical processes in rat retinal pigment epithelium. Kusaka, S., Inanobe, A., Fujita, A., Makino, Y., Tanemoto, M., Matsushita, K., Tano, Y., Kurachi, Y. J. Physiol. (Lond.) (2001) [Pubmed]
  9. Specific localization of an inwardly rectifying K(+) channel, Kir4.1, at the apical membrane of rat gastric parietal cells; its possible involvement in K(+) recycling for the H(+)-K(+)-pump. Fujita, A., Horio, Y., Higashi, K., Mouri, T., Hata, F., Takeguchi, N., Kurachi, Y. J. Physiol. (Lond.) (2002) [Pubmed]
  10. Genomic structure and promoter analysis of the rat kir7.1 potassium channel gene (Kcnj13). Döring, F., Karschin, A. FEBS Lett. (2000) [Pubmed]
  11. Stable cation coordination at a single outer pore residue defines permeation properties in Kir channels. Wischmeyer, E., Döring, F., Karschin, A. FEBS Lett. (2000) [Pubmed]
 
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