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Gene Review

BCRF1  -  BCRF1 protein precursor

Human herpesvirus 4

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Disease relevance of BCRF1


High impact information on BCRF1


Anatomical context of BCRF1


Other interactions of BCRF1

  • Latent BHRF1 transcripts encoding bcl-2 homologue and BCRF1 transcripts encoding viral interleukin (vIL)-10 were detected in one and two of eight patients, respectively [10].


  1. Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1. Hsu, D.H., de Waal Malefyt, R., Fiorentino, D.F., Dang, M.N., Vieira, P., de Vries, J., Spits, H., Mosmann, T.R., Moore, K.W. Science (1990) [Pubmed]
  2. In vivo production of interleukin-10 by malignant cells in AIDS lymphomas. Emilie, D., Touitou, R., Raphael, M., Peuchmaur, M., Devergnee, O., Rea, D., Coumbraras, J., Crevon, M.C., Edelman, L., Joab, I. Eur. J. Immunol. (1992) [Pubmed]
  3. Human B cell interleukin 10. Benjamin, D., Park, C.D., Sharma, V. Leuk. Lymphoma (1994) [Pubmed]
  4. Interleukin-10 and its receptor. Ho, A.S., Moore, K.W. Therapeutic immunology. (1994) [Pubmed]
  5. Detection of Epstein-Barr virus RNA and related antigens in non-neoplastic lymphoid lesions. Tonoyama, Y., Teramoto, N., Sarker, A.B., Yoshino, T., Hayashi, K., Takahashi, K., Akagi, T. Acta Med. Okayama (1996) [Pubmed]
  6. Viral interleukin 10 is critical for the induction of B cell growth transformation by Epstein-Barr virus. Miyazaki, I., Cheung, R.K., Dosch, H.M. J. Exp. Med. (1993) [Pubmed]
  7. Epstein-Barr virus recombinants with specifically mutated BCRF1 genes. Swaminathan, S., Hesselton, R., Sullivan, J., Kieff, E. J. Virol. (1993) [Pubmed]
  8. Frequent recognition of BCRF1, a late lytic cycle protein of Epstein-Barr virus, in the HLA-B*2705 context: evidence for a TAP-independent processing. Saulquin, X., Bodinier, M., Peyrat, M.A., Hislop, A., Scotet, E., Lang, F., Bonneville, M., Houssaint, E. Eur. J. Immunol. (2001) [Pubmed]
  9. Epstein-Barr virus encoded interleukin-10 inhibits HLA-class I, ICAM-1, and B7 expression on human monocytes: implications for immune evasion by EBV. Salek-Ardakani, S., Arrand, J.R., Mackett, M. Virology (2002) [Pubmed]
  10. The latency pattern of Epstein-Barr virus infection and viral IL-10 expression in cutaneous natural killer/T-cell lymphomas. Xu, Z.G., Iwatsuki, K., Oyama, N., Ohtsuka, M., Satoh, M., Kikuchi, S., Akiba, H., Kaneko, F. Br. J. Cancer (2001) [Pubmed]
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