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Gene Review

Nop60B  -  Nucleolar protein at 60B

Drosophila melanogaster

Synonyms: CG333, CG3333, Dmel\CG3333, FBgn0023184, H/ACA ribonucleoprotein complex subunit 4, ...
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Disease relevance of Nop60B


High impact information on Nop60B


Biological context of Nop60B


Anatomical context of Nop60B

  • Nop60B RNA is found at high levels in nurse cells and in the oocyte, and is present throughout development [4].

Analytical, diagnostic and therapeutic context of Nop60B

  • While P-element induced total loss-of-function mutations cause lethality, mfl partial loss-of-function mutations cause pleiotropic defects, such as extreme reduction of body size, developmental delay, hatched abdominal cuticle, and reduced female fertility [2].


  1. Mutations in Nop60B, the Drosophila homolog of human dyskeratosis congenita 1, affect the maintenance of the germ-line stem cell lineage during spermatogenesis. Kauffman, T., Tran, J., DiNardo, S. Dev. Biol. (2003) [Pubmed]
  2. minifly, a Drosophila gene required for ribosome biogenesis. Giordano, E., Peluso, I., Senger, S., Furia, M. J. Cell Biol. (1999) [Pubmed]
  3. The slender lobes gene, identified by retarded mushroom body development, is required for proper nucleolar organization in Drosophila. Orihara-Ono, M., Suzuki, E., Saito, M., Yoda, Y., Aigaki, T., Hama, C. Dev. Biol. (2005) [Pubmed]
  4. The Nop60B gene of Drosophila encodes an essential nucleolar protein that functions in yeast. Phillips, B., Billin, A.N., Cadwell, C., Buchholz, R., Erickson, C., Merriam, J.R., Carbon, J., Poole, S.J. Mol. Gen. Genet. (1998) [Pubmed]
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