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Gene Review:

RBMY2VP - RNA binding motif protein, Y-linked,...

Homo sapiens

Makrinou, E. et al., Shimmin, L.C. et al., Shimmin, L.C. et al., Lovell-Badge, R., Smith, D.W. et al., et al.

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Disease relevance of RBMY2VP

Tentative evidence of Y-linked statural gene(s). Growth in the testicular feminization syndrome [1].

Psychiatry related information on RBMY2VP

The Y-linked gene Sry acts during a critical period of gonadal differentiation to divert the normal or default pathway of gene activity that would otherwise lead to the development of ovaries into one that leads to the development of testes [2].

High impact information on RBMY2VP

As the number of X-linked genes used in the study was small and the X-linked and autosomal sequences were non-homologous, and given that the synonymous rate varies among genes, we sequenced the last intron (approximately 1 kb) of the Y-linked and X-linked zinc-finger-protein genes (ZFY and ZFX) in humans, orang-utans, baboons and squirrel monkeys [3].
We have sequenced the entire exon (approximately 1.180 bp) encoding the zinc finger domain of the X-linked and Y-linked zinc finger genes (ZFX and ZFY, respectively) in the orangutan, the baboon, the squirrel monkey, and the rat; a total of 9,442 bp were sequenced [4].
Screening a testis cDNA selection library for Y-linked genes yielded 79 cDNAs [5].
Fluoresence in situ hybridisation and PCR amplification were used to localise a large number of DNM1-like sequences to human chromosomes 15 and Y. PCR amplification of overlapping Y-linked YACs allowed a more accurate mapping of the Y-linked DNM1-like cDNAs to a euchromatic locus in close proximity to heterochromatin at Yq11.23 [5].
Transcription of paternal Y-linked genes in the human zygote as early as the pronucleate stage [6].

Biological context of RBMY2VP

Contrasting rates of nucleotide substitution in the X-linked and Y-linked zinc finger genes [4].

Associations of RBMY2VP with chemical compounds

These data are interpreted as evidence for one or more Y-linked gene function(s) which augment stature independently of testosterone effects [1].

References

Tentative evidence of Y-linked statural gene(s). Growth in the testicular feminization syndrome. Smith, D.W., Marokus, R., Graham, J.M. Clinical pediatrics. (1985) [Pubmed]
Sex determining gene expression during embryogenesis. Lovell-Badge, R. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1993) [Pubmed]
Male-driven evolution of DNA sequences. Shimmin, L.C., Chang, B.H., Li, W.H. Nature (1993) [Pubmed]
Contrasting rates of nucleotide substitution in the X-linked and Y-linked zinc finger genes. Shimmin, L.C., Chang, B.H., Li, W.H. J. Mol. Evol. (1994) [Pubmed]
DNM1DN: a new class of paralogous genomic segments (duplicons) with highly conserved copies on chromosomes Y and 15. Makrinou, E., Fox, M., Wolfe, J., Cameron, J., Taylor, K., Edwards, Y.H. Ann. Hum. Genet. (2004) [Pubmed]
Transcription of paternal Y-linked genes in the human zygote as early as the pronucleate stage. Ao, A., Erickson, R.P., Winston, R.M., Handyside, A.H. Zygote (1994) [Pubmed]

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