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Gene Review

Gad1  -  Glutamic acid decarboxylase 1

Drosophila melanogaster

Synonyms: CG14994, DGAD1, DGad1, Dmel\CG14994, GAD, ...
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Disease relevance of Gad1


High impact information on Gad1


Biological context of Gad1

  • A mammalian glutamic acid decarboxylase (GAD) cDNA probe has been utilized to isolate Drosophila cDNA clones that represent a genomic locus in chromosome region 64A [5].
  • Transcriptional analyses show that expression of the Drosophila Gad gene commences early in embryonic development (4-8 h) and continues in all later developmental stages [5].
  • A transcriptional regulatory element of the gene encoding the 67,000-M(r) form of human glutamate decarboxylase is similar to a Drosophila regulatory element [6].
  • One of these rearrangements, Df(3L)C175, is a small deletion that removes the Gad locus and at least two essential genes; the second, T(2;3)F10, is a reciprocal translocation involving the second and third chromosomes with a break within region 64A3-5 [7].
  • Next, we discuss the role of two proteins that forward genetic screens in Drosophila have revealed to play crucial-and completely unexpected-roles in NMJ development and plasticity: the origin of replication complex protein Latheo, and the enzyme glutamate decarboxylase [8].

Associations of Gad1 with chemical compounds


  1. Sequence studies on pyridoxal phosphate-dependent enzymes. Bossa, F., Maras, B., De Biase, D., John, R.A., Barra, D. Biotechnol. Appl. Biochem. (1993) [Pubmed]
  2. In developing Drosophila neurones the production of gamma-amino butyric acid is tightly regulated downstream of glutamate decarboxylase translation and can be influenced by calcium. Küppers, B., Sánchez-Soriano, N., Letzkus, J., Technau, G.M., Prokop, A. J. Neurochem. (2003) [Pubmed]
  3. A neural gene from Drosophila melanogaster with homology to vertebrate and invertebrate glutamate decarboxylases. Phillips, A.M., Salkoff, L.B., Kelly, L.E. J. Neurochem. (1993) [Pubmed]
  4. Transcriptional organization of a Drosophila glutamic acid decarboxylase gene. Newby, L.M., Kulkarni, S.J., Jackson, F.R. J. Neurochem. (1993) [Pubmed]
  5. Drosophila GABAergic systems: sequence and expression of glutamic acid decarboxylase. Jackson, F.R., Newby, L.M., Kulkarni, S.J. J. Neurochem. (1990) [Pubmed]
  6. A transcriptional regulatory element of the gene encoding the 67,000-M(r) form of human glutamate decarboxylase is similar to a Drosophila regulatory element. Erlander, M.G., Tobin, A.J. J. Neurochem. (1992) [Pubmed]
  7. Drosophila GABAergic systems. II. Mutational analysis of chromosomal segment 64AB, a region containing the glutamic acid decarboxylase gene. Kulkarni, S.J., Newby, L.M., Jackson, F.R. Mol. Gen. Genet. (1994) [Pubmed]
  8. Surprises from Drosophila: genetic mechanisms of synaptic development and plasticity. Featherstone, D.E., Broadie, K. Brain Res. Bull. (2000) [Pubmed]
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