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Gene Review

Akh  -  Adipokinetic hormone

Drosophila melanogaster

Synonyms: AKH, AKH1, CG1171, Dmel\CG1171, Drm-AKH, ...
 
 
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High impact information on Akh

 

Biological context of Akh

 

Anatomical context of Akh

  • Trehalose levels were decreased in larvae and starved adults, when the stimulation by AKH of the production of trehalose from fat body glycogen is no longer possible [6].
  • Phosporamidon (10 microM), a selective inhibitor of mammalian endopeptidase 24:11, was able to fully protect AKH I from degradation by head membranes [7].
 

Associations of Akh with chemical compounds

  • AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila [6].
 

Other interactions of Akh

  • These results are intriguing, because not only are the Drosophila AKH and corazonin receptors structurally and evolutionarily related, but also are their preprohormones, which suggests a co-evolution of ligands and receptors [5].
 

Analytical, diagnostic and therapeutic context of Akh

References

  1. Molecular identification of the insect adipokinetic hormone receptors. Staubli, F., Jorgensen, T.J., Cazzamali, G., Williamson, M., Lenz, C., Sondergaard, L., Roepstorff, P., Grimmelikhuijzen, C.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster. Lee, G., Park, J.H. Genetics (2004) [Pubmed]
  3. The fruitfly Drosophila melanogaster contains a novel charged adipokinetic-hormone-family peptide. Schaffer, M.H., Noyes, B.E., Slaughter, C.A., Thorne, G.C., Gaskell, S.J. Biochem. J. (1990) [Pubmed]
  4. Immunolocalization of a tachykinin-receptor-like protein in the central nervous system of Locusta migratoria migratorioides and neobellieria bullata. Veelaert, D., Oonk, H.B., Vanden Eynde, G., Torfs, H., Meloen, R.H., Schoofs, L., Parmentier, M., De Loof, A., Vanden Broeck, J. J. Comp. Neurol. (1999) [Pubmed]
  5. Molecular cloning and functional expression of a Drosophila corazonin receptor. Cazzamali, G., Saxild, N., Grimmelikhuijzen, C. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  6. AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila. Isabel, G., Martin, J.R., Chidami, S., Veenstra, J.A., Rosay, P. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  7. Metabolism of insect neuropeptides: properties of a membrane-bound endopeptidase from heads of Musca domestica. Lamango, N.S., Isaac, R.E. Insect Biochem. Mol. Biol. (1993) [Pubmed]
  8. Molecular cloning of three distinct cDNAs, each encoding a different adipokinetic hormone precursor, of the migratory locust, Locusta migratoria. Differential expression of the distinct adipokinetic hormone precursor genes during flight activity. Bogerd, J., Kooiman, F.P., Pijnenburg, M.A., Hekking, L.H., Oudejans, R.C., Van der Horst, D.J. J. Biol. Chem. (1995) [Pubmed]
 
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